In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation by Sleiman, Sama F.

“…We observed ATP depletion under OGD vs. hypoxia and propose that ATP depletion enhances translational suppression, overcoming the selective synthesis of HIF concurrent with global decreases in protein synthesis in hypoxia. Taken together, these findings biochemically characterize a practical reporter for monitoring HIF-1α levels and support a novel model for HIF regulation in an in vitro model of human ischemia.…”
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Maternal Body Mass Index and Recommended Gestational Weight Gain in a Middle Eastern Setting by Tawa Olukade (11619453)

“…</p><h3>Results</h3><p dir="ltr">The mean maternal age was 29.7 ± 5.5 years, prepregnancy BMI was 27.5 ± 5.8 kg/m2, GWG was 9.58 kg ± 6.87 kg and gestational age at birth was 38.5 ± 1.9 weeks. In line with IOM recommendations, we found that higher BMI was correlated with decreased GWG and BMI was significantly associated with GWG even after adjusting for maternal age, parity, and infants’ gestational age at birth. …”

PROACT: Parallel multi-miner proof of accumulated trust protocol for Internet of Drones by Mershad, Khaleel

“…In addition, we propose a new blockchain consensus mechanism in which several miners produce their blocks in parallel, which decreases the time needed to add transactions securely to the blockchain and meets the requirements of delay-sensitive applications. …”
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Effects of electrolytes and suwannee river humic acid on the aggregation behavior of silicon nanoparticles by Wazne, Mahmoud

“…Studies about the impact of the release of silicon nanomaterials to the environment and on human health by the microelectronics and biomedical devices industries are urgently needed. The aggregation kinetics of silicon NPs was investigated using dynamic light scattering (DLS) and electron microscope (EM) in the presence of Ca2+ and Suwannee River Humic Acid (SRHA). …”
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The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR) by Varghese P. Inchakalody (14557382)

“…Therefore, we investigated the molecular mechanisms accompanied with the epigenetic regulation of NY-ESO-1 in 5-Aza-CdR-treated NCI–H1975 cell line. We showed significant induction of the NY-ESO-1 protein (**p < 0.0097) using Cellular ELISA. …”

Sitagliptin/Simvastatin by Ramadan, Wijdan H.

“…Both medications have also demonstrated an acceptable side effect profile. However, caution is needed when coadministering with any drug that may increase simvastatin levels to reduce the risk of myopathy and rhabdomyolysis. …”
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STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration by Ayat S. Hammad (9592374)

“…SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. …”

Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression by Rayanah Barnawi (8737584)

“…Herein, fascin ShRNA was used to generate stable fascin knockdown (FSCN1^KD) in the MDA-MB-231 TNBC cell line and then were subjected to comprehensive mRNA and miRNA transcriptome analysis. …”

Percutaneous Transhepatic Bile Duct Ablation with n-Butyl Cyanoacrylate in the Treatment of a Biliary Complication after Split Liver Transplantation by Lauterio, Andrea

“…Further studies are needed to determine whether this approach is effective and safe and whether it could reduce hospital stay and cost.…”
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Heat Transfer Coefficient Estimation of Falling Film for Horizontal Tube Multi-Effect Desalination Evaporator Using CFD by Furqan Tahir (14429547)

“…Furthermore, the higher operating temperature limit should be increased instead of decreasing operating temperature for improved heat transfer performance.…”

Techno-economic and environmental analyses of the pyrolysis of food waste to produce bio-products by Mohammad Alherbawi (14155767)

“…The water footprint increased with increasing pyrolysis temperature but decreased with increasing moisture content in all scenarios. …”

Production of self-compacting concrete using Jordanian oil shale ash by Ashteyat, Ahmed

“…The strength of the SCC concrete decreased with higher OSA replacement contents although maintaining a higher value than that of conventional concrete made at almost the same cement factor. …”
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Fixed-interval versus OCT-guided variable dosing of intravitreal bevacizumab in the management of neovascular age-related macular degeneration by El-Mollayess, Georges M.

“…Purpose To compare the efficacy of as-needed or variable dosing of intravitreal bevacizumab to continuous fixed-interval dosing in the management of neovascular age-related macular degeneration (AMD). …”
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Analysis of Innovative Vapor Compression and Thermal Energy Storage Systems Using Alternative Refrigerants by Morad, Bahaa

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Assessment of Knowledge, Attitude and Practice towards Sustainability Aspects among Higher Education Students in Qatar by Shaikha R. Al-Nuaimi (19488232)

“…<p dir="ltr">Sustainable development necessitates that societies design activities to meet human needs while protecting the planet’s life-support systems in consideration of depleting natural resources and concern for the state of the resources and climate. …”

Performance Simulation of Single- and Double-Effect Absorption Refrigeration Systems Used for Solar Cooling Applications by Al Kaab, Noor Sameer Ali

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Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications by Fang Yu (156838)

“…They further establish the SOCE hypomorph line as a genetic model to define the therapeutic window of SOCE inhibition and dissect toxicities associated with chronic SOCE inhibition in a tissue-specific fashion.…”

Breaking the barriers towards large-scale microalgae-based bio-hydrogen production by Isra Koko (22631396)

“…Results showed that cultivation dominates the process cost: typical biomass costs are $3.54–$5.78/kg in tubular PBRs versus $3.42–$4.13/kg in ORPs; an automation/modularization case decreased microalgae production cost from $89 to $16/kg at ∼200 t/yr. …”

Muscle protein anabolism in type 2 diabetes by Bassil, Maya S.

“…Whether leucine supplementation improves muscle mass and function in persons with T2DM (especially elderly) with reduced protein intake or muscle mass needs to be determined.…”
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Crystallization properties of arsenic doped GST alloys by Vinod E. Madhavan (8136774)

“…Optical band gap (E_opt) values of the as-deposited films show a clear increasing trend; 0.6 eV for GST to 0.76 eV for (GST)_0.85As_0.15. The decreases in E_opt for the samples annealed at higher temperatures shows significant optical contrast between the as-deposited and annealed samples. …”