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461
Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response
Published 2019“…These observations support the need to consider anti-NRP-1 as a potential targeted therapy for breast cancer patients who are identified with high NRP-1 levels. …”
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462
Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans
Published 2021“…<h3>Background</h3><p dir="ltr">Parkinson’s disease is a disabling neurodegenerative movement disorder characterized by dopaminergic neuron loss induced by α-synuclein oligomers. There is an urgent need for disease-modifying therapies for Parkinson’s disease, but drug discovery is challenged by lack of in vivo models that recapitulate early stages of neurodegeneration. …”
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463
An Evaluation of Short-Term Effects of Different Soil Management Systems on Soil Physical, Structural and Hydraulic Properties and an Estimation and Optimization of Water Infiltrat...
Published 2022“…Nevertheless, implementing all management systems to determine water infiltration capacities for a specific site can be costly and time-consuming. Hence, the need for a mathematical model that computes infiltration into agricultural soils is necessary. …”
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464
Optimal management, prevalence, and clinical behavior of saddle pulmonary embolism: A systematic review and meta-analysis
Published 2022“…Female sex (61.5 % vs. 41.3 %, p = 0.019), hypoxemia (90 % vs. 59.2 %, p < 0.001), massive PE features (89.7 % vs. 30.1 %, p < 0.001), associated chronic kidney disease (CKD) (10.3 % vs. 1.4 %, p = 0.002), and the need for mechanical ventilation (28.2 % vs. 13.1 %, p = 0.02) were significantly associated with increased mortality. …”
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465
Mitigating the impact of cultural diversity on the innovation process in the private sector in Dubai
Published 2017“…The author further noted that cultural diversity has formed a paramount issue in business arena that need to be investigated to pave a clear way in order to accommodate people from various backgrounds. …”
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466
Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis...
Published 2021“…Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally.…”
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467
The burden of unintentional drowning: global, regional and national estimates of mortality from the Global Burden of Disease 2017 Study
Published 2020“…The results reinforce the need for continued and improved policy, prevention and research efforts, with a focus on low- and middle-income countries.…”
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468
Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021
Published 2023“…By 2050, 89 (43·6%) of 204 countries and territories will have an age-standardised rate greater than 10%. InterpretationDiabetes remains a substantial public health issue. …”
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469
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470
Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Bur...
Published 2020“…Global ambitions to accelerate progress on UHC service coverage are increasingly unlikely unless concerted action on non-communicable diseases occurs and countries can better translate health spending into improved performance. …”
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471
Effects of visual field impairment on driving
Published 2015“…Furthermore, the analysis needs to be complemented with an analysis which consider diagnosis and cognitive status.…”
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472
Measuring universal health coverage based on an index of effective coverage of health services in 204 countries and territories, 1990–2019: a systematic analysis for the Global Bur...
Published 2020“…Global ambitions to accelerate progress on UHC service coverage are increasingly unlikely unless concerted action on non-communicable diseases occurs and countries can better translate health spending into improved performance. …”
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473
A nonlinear PID servo controller for computer hard disk drives
Published 2020“…The controller is capable of increasing (decreasing) damping effect when the system output is moving away from (towards) the desired track. …”
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474
Exogenous Contrast Agents in Photoacoustic Imaging: An In Vivo Review for Tumor Imaging
Published 2022“…Therefore, improved diagnostics are needed to define in vivo tumor growths on a molecular level to achieve image-guided therapies and tailored dosage needs. …”
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475
Exogenous Contrast Agents in Photoacoustic Imaging: An In Vivo Review for Tumor Imaging
Published 2022“…Therefore, improved diagnostics are needed to define in vivo tumor growths on a molecular level to achieve image-guided therapies and tailored dosage needs. …”
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476
PROACT: Parallel multi-miner proof of accumulated trust protocol for Internet of Drones
Published 2022“…In addition, we propose a new blockchain consensus mechanism in which several miners produce their blocks in parallel, which decreases the time needed to add transactions securely to the blockchain and meets the requirements of delay-sensitive applications. …”
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477
Effects of electrolytes and suwannee river humic acid on the aggregation behavior of silicon nanoparticles
Published 2017“…Studies about the impact of the release of silicon nanomaterials to the environment and on human health by the microelectronics and biomedical devices industries are urgently needed. The aggregation kinetics of silicon NPs was investigated using dynamic light scattering (DLS) and electron microscope (EM) in the presence of Ca2+ and Suwannee River Humic Acid (SRHA). …”
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478
Sitagliptin/Simvastatin
Published 2016“…Both medications have also demonstrated an acceptable side effect profile. However, caution is needed when coadministering with any drug that may increase simvastatin levels to reduce the risk of myopathy and rhabdomyolysis. …”
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479
Percutaneous Transhepatic Bile Duct Ablation with n-Butyl Cyanoacrylate in the Treatment of a Biliary Complication after Split Liver Transplantation
Published 2009“…Further studies are needed to determine whether this approach is effective and safe and whether it could reduce hospital stay and cost.…”
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480
Heat Transfer Coefficient Estimation of Falling Film for Horizontal Tube Multi-Effect Desalination Evaporator Using CFD
Published 2021“…Furthermore, the higher operating temperature limit should be increased instead of decreasing operating temperature for improved heat transfer performance.…”