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421
Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans
Published 2021“…Next, we devised a method for semi-automated and blinded quantification of motor impairment for a population of simultaneously recorded animals with multi-worm tracking and custom image processing. …”
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422
Deletion of <i>RFX6</i> impairs iPSC-derived islet organoid development and survival, with no impact on PDX1<sup>+</sup>/NKX6.1<sup>+</sup> progenitors
Published 2024“…Furthermore, induced pluripotent stem cell (iPSC) lines lacking RFX6 were generated using CRISPR/Cas9. …”
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423
Application of Emotional Intelligence in Surgical Education: A Scoping Review
Published 2025“…<h3>Background</h3><p dir="ltr">Emotional Intelligence (EI) encompasses the ability to perceive, understand, and manage emotions and is increasingly recognized as a vital nontechnical (soft) skill within surgical education. …”
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424
Genomic Landscape And Structural Impact Of Biotinidase (BTD) Variants In A Middle Eastern Population
Published 2025“…MD simulations indicated that H323R, D444H, and P497S exhibited greater structural flexibility (increased RMSD/RMSF and PCA trace values), whereas R209C and D444H demonstrated reduced compactness (higher radius of gyration). …”
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425
Internet Searches for Medical Symptoms Before Seeking Information on 12-Step Addiction Treatment Programs: A Web-Search Log Analysis
Published 2019“…Second, we examined symptom queries preceding queries on the 12-step program at time lags of 0-7 days, 7-14 days, and 14-30 days, where the probability of asking about a medical symptom was greater in the 30-day time window preceding 12-step program information-seeking as compared to all previous times that the symptom was queried.…”
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426
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427
Conflicts Employee-Employee
Published 2012“…The researcher hopes that future researchers may overcome the limitations and identify more effective solutions for decreasing conflicts among employees.…”
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428
Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function
Published 2017“…Conversely, knock-down of MMP-8 in N-1089 reduced adhesion and increased migration. Expression of MMP-8 WT in β6-1089 led to greater localisation of α6β4 to HD and reduced retraction fibre formation, this being reversed by MMP-8 knock-down in N-1089. …”
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429
A single-institution review of 157 patients presenting with benign and malignant tumors of the ampulla of Vater
Published 2011“…Lymph node involvement was predictive of recurrence and decreased survival. Conclusion Patients with malignant tumors often present with jaundice and larger tumors. …”
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430
Arginine Deprivation in AML Cells Induces Ferroptosis, a Type of Autophagy-Mediated Cell Death
Published 2023“…Scavenging ROS using NAC significantly decreases cell death but has minimal effect on autophagy activation, suggesting that the accumulation of ROS is downstream of autophagy activation but upstream of cell death. …”
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masterThesis -
431
Effect of climate change on the annual energy consumption of a single family house in British Columbia
Published 2018“…The Earth is already experiencing some of the effects of climate change, such as rising temperature, more frequent storms, increased precipitation, etc. …”
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432
Epibenthic communities from offshore platforms in the Arabian Gulf are structured by platform age and depth
Published 2021“…The lowest number of functional groups occurred in the early ages (2–3 years old), and some groups either increased or decreased their frequency and abundance along the years. …”
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433
Essays on international environmental policy
Published 2009“…With the growing talk about the need to establish a new framework to deal with international environmental governance, it becomes relevant to shed some light on the interconnected landscape that characterizes environmental policy making. …”
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masterThesis -
434
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435
Fraud
Published 2017“…Additional testing that is over and above their responsibilities is being done in some cases due to auditors' concerns for their reputation. …”
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436
Prevalence and attributable health burden of chronic respiratory diseases, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017
Published 2020“…Deaths due to chronic respiratory diseases numbered 3 914 196 (95% UI 3 790 578–4 044 819) in 2017, an increase of 18·0% since 1990, while total DALYs increased by 13·3%. …”
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437
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438
Effects of the addition of a high energy density fuel, adamantane to diesel on its cetane number, sooting propensity, and soot nanostructural properties
Published 2022“…Soot particles, released during diesel combustion, adversely affect human health and the environment. Some studies suggest blending diesel with oxygenated fuels to reduce soot emissions, though it also reduces fuel economy and may produce new pollutants such as aldehydes. …”
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439
An Evaluation of Short-Term Effects of Different Soil Management Systems on Soil Physical, Structural and Hydraulic Properties and an Estimation and Optimization of Water Infiltrat...
Published 2022“…However, the addition of organic matter enhanced such qualities with some limitations. The advantage of tilled layers over undisturbed soils is the better conductivity of water due to larger and better sorted pores. …”
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masterThesis -
440
Ablation of LAT2 Transporter Causes Intramuscular Glutamine Accumulation and Inhibition of Fasting‐Induced Proteolysis
Published 2025“…Decreased proteolysis in LAT2KO animals was associated with increased mTORC1 translocation to the lysosome (mTORC1‐Lamp1 colocalization in fasted LAT2KO muscles was 1.23‐fold, <i>p</i> < 0.0001). …”