Novel thiazolones for the simultaneous modulation of PPARγ, COX-2 and 15-LOX to address metabolic disease-associated portal inflammation by Mai S., El-Shoukrofy

“…Compound 2a activated PPARγ with an EC50 value of 3.4 μM in a Gal4-hybrid reporter gene assay, indicating partial agonistic action. …”
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PSA-activated proaerolysin as a prostate specific cancer therapy by Abi-Habib, Ralph

“…Activity toward proaerolysin was decreased 10-100 fold for each of the proteases tested except PSA, which showed a 4-fold increase in activity against the modified protein. …”
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Synergistic Effect of Epigenetic Inhibitors Decitabine and Suberoylanilide Hydroxamic Acid on Colorectal Cancer In vitro by Najem, Sonia A.

“…Results: Our results showed that SAHA and DAC, separately, significantly decreased cell proliferation, induced apoptosis and cell cycle arrest of Caco-2 cell line. …”
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Klotho overexpression protects human cortical neurons from β-amyloid induced neuronal toxicity by Mohammed R. Shaker (10316180)

“…Our data reveal that upregulation of <i>KLOTHO</i> significantly reduced β-amyloid-induced neuronal degeneration and apoptosis, as evidenced by decreased cleaved caspase-3 expression and preservation of axonal integrity. …”

Wind shear coefficient, turbulence intensity and wind power potential assessment for Dhulom, Saudi Arabia by Rehman, Shafiqur

“…Furthermore, lower values were obtained during November to March and higher during rest of the year. Finally, a decreasing pattern was observed in the values of TIs with increasing height.…”
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Composite hydrogels from carrageenan-cl-carboxymethyl chitosan–PVA incorporated ZiF-8 as dressing material for wound healing applications by Tooba Yasin (19131382)

“…It was found that increasing ZiF-8 decreases the swelling in different media and increases degradation in PBS media. …”

Exploring Unique Physiological and Genetic Features of Desert-dwelling Legumes by Madhurima Chatterjee (5331215)

Identification of macrophage activation-related biomarkers in obese type 2 diabetes that may be indicative of enhanced respiratory risk in COVID-19 by Abu Saleh Md Moin (6189512)

“…Two potent M1 macrophage activation markers, CXCL9 and CXCL10, were decreased in OT2D. Activated M2 macrophages were characterized by elevated levels of plasma CD163, TFGβ-1, MMP7 and MMP9 in OT2D. …”

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss by Meritxell Espino Guarch (18810097)

“…The disease has a multifactorial etiology with both environmental and genetic factors involved being largely unknown. SLC7A8/SLC3A2 heterodimer is a neutral amino acid exchanger. …”

The Trace Element Composition of Size Fractionated Suspended Particulate Matter Samples from the Qatari EEZ of the Arabian Gulf: The Role of Atmospheric Dust by Oguz Yigiterhan (14151006)

“…Because surface seawater is supersaturated with respect to CaCO3 and acid soluble Ca is abundant in the particulate matter, we only used unleached dust for the lithogenic correction. …”

Nebulized fentanyl for respiratory symptoms in patients with COVID-19 (ventanyl trial) by Nissar Shaikh (11659441)

“…The proposed theory behind that was that fentanyl decreased the rate of spontaneous respiratory rate, diminished the brain stem chemoreceptor response to hypoxia and hypercarbia, in addition to exhibiting a modulating effect on the brain stem. …”

Upgrading co-pyrolysis products from ternary biomass: An investigative study of commercial and locally-made catalysts by Sabah Mariyam (14150859)

“…Notably, CaCO₃ exhibits the highest bio-oil yield, while Ca(OH)₂ shows the lowest, with reversed trends observed for gas yields. …”

Numerical analysis of spatial distribution of carbon in methane dry reforming over supported nickel catalyst in a packed bed reactor by Ahmed Aheed Ali Mohammed (22155979)

“…As the temperature increased, the total carbon deposition decreased, although this reduction became negligible beyond 850 °C. …”

Towards Industry 4.0 and Sustainable Manufacturing Applying Environmentally Friendly Machining of a Precipitation Hardened Stainless Steel Using Hot Turning Process by Mohammadjafar Hadad (17541345)

“…In this research, the conventional and hot turning of AISI630 hardened stainless steel have been investigated using PVD-(Ti,Al)N/(Al,Cr)₂O₃ coated carbide cutting tools at various feed rates and cutting speeds. …”

A Decision Support Model for Prequalifying IPD Project Participants in Construction Projects by El Masri, Ahmad

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Immunoprofile of childhood diabetes by Meritxell Espino-Guarch (15430868)

Biomarkers show promise for treatment of heart valve disease by Nature Research (16552612)

Activation of Src kinase in primary colorectal carcinoma An indicator of poor clinical prognosis by Allgayer, Heike

“…In patients who underwent curative resection, a significant correlation with a decreased disease-free survival rate was found (P < 0.0001). …”
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Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis by Osama Hussein (21301202)

“…For OAG patients, the pooled effect showed an IOPR% of 18.94% with a significant absolute change of −4.35 mmHg, <i>p</i> < 0.001 at 12 months, and IOPR% of 16.95% with an absolute IOP change of −3.83 mmHg, <i>p</i> < 0.001 at 24 months. In ACG patients, medication use decreased by 67.13% at 12 months and 51.58% at 24 months (<i>p</i> < 0.001 for both), while in OAG patients, the reduction was 45.52% at 12 months and 50.19% at 24 months (<i>p</i> < 0.001). …”

Synergetic effects of dodecylamine-functionalized graphene oxide nanoparticles on antifouling and antibacterial properties of polysulfone ultrafiltration membranes by Abedalkader Alkhouzaam (15842647)

“…Against HA, FRR was improved from 87.8 % for neat PSF to 95.6 % and 99.3 % with GO-0.1 and rGO-DDA-0.1, respectively. …”