The Effect of Atorvastatin (and Subsequent Metformin) on Adipose Tissue Acylation-Stimulatory-Protein Concentration and Inflammatory Biomarkers in Overweight/Obese Women With Polyc... by Thozhukat Sathyapalan (704787)

“…Following the 12 week randomization; both group of women with PCOS were subsequently started on metformin 1,500 mg daily for further 12 weeks to assess whether pre-treatment with atorvastatin potentiates the effects of metformin on markers of adipose tissue function We conducted a post-hoc review to detect plasma ASP and the pro-inflammatory cytokines IL6 and MCP-1 before and after 12 and 24 weeks of treatment.</p><h3>Results</h3><p dir="ltr">There was significant reduction in ASP (156.7 ± 16.2 vs. 124.4 ± 14.8 ng/ml p <0.01), IL-6 (1.48 ± 0.29 vs.0.73 ± 0.34 pg/ml p = 0.01) and MCP-1 (30.4 ± 4.2 vs. 23.0 ± 4.5 pg/ml p = 0.02) after 12 weeks of atorvastatin that was maintained subsequently with 12 weeks treatment with metformin. …”

Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response by Noura Al-Zeheimi (5177066)

“…To further identify the role of NRP-1 and its interacting molecules in correspondence with patients' response to neoadjuvant chemotherapy (NAC), we conducted a comparative study on blood and tissue samples collected from a cohort of locally advanced breast cancer patients, before and after neoadjuvant chemotherapy (NAC). From a panel of tested proteins and genes, we found that the levels of plasma NRP-1, placenta growth factor (PlGF) and immune cell expression of the transcription factor <i>SNAI1</i> before and after NAC were significantly different. …”

Positional and dimensional temporomandibular joint osseous changes in patients treated with the forsus fatigue resistant device: a non-randomized clinical trial by Ramy Abdul-Rahman Ishaq (22928974)

“…Participants were divided into a treatment and a control group. After alignment and leveling with fixed orthodontic appliances using 0.019 × 0.025-inch stainless-steel archwires, the FFRD was fitted. …”

Epibenthic communities from offshore platforms in the Arabian Gulf are structured by platform age and depth by Felipe, Torquato

“…A step further is now required to determine whether these platform foundations should be converted to reefs after their decommissioning (i.e., Rigs to Reefs approach).…”
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Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function by Muge Sarper (3855454)

“…Conversely, knock-down of MMP-8 in N-1089 reduced adhesion and increased migration. Expression of MMP-8 WT in β6-1089 led to greater localisation of α6β4 to HD and reduced retraction fibre formation, this being reversed by MMP-8 knock-down in N-1089. …”

Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss by Meritxell Espino Guarch (18810097)

“…</p><h2>Other Information</h2><p dir="ltr">Published in: eLife<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.7554/elife.31511" target="_blank">https://dx.doi.org/10.7554/elife.31511</a></p>…”

Enhanced PSO-Based NN for Failures Detection in Uncertain Wind Energy Systems by Khaled Dhibi (16891524)

“…The proposed methodology improves the diagnosis abilities, reduces the computation time, and decreased the storage cost. The presented experimental results prove the high performance of the suggested paradigms in terms of computation time and accuracy.…”

Graph-Guided Regularized Regression of Pacific Ocean Climate Variables to Increase Predictive Skill of Southwestern U.S. Winter Precipitation by Tejedor, Alejandro

“…Physics-based deterministic models show limited ability to predict precipitation as the lead time increases, due to imperfect representation of physical processes and incomplete knowledge of initial conditions. …”
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The effect of the local inertial term on the fluid flow in channels partially filled with porous material by Abu-Hijleh, B.A.

“…Also, it is found that the deviation between the predictions of the transient and the quasi-steady models is more significant in the porous domain and the deviation decreases as the time proceeds.…”
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Pharmacist Role in Hypertension Management in the Community Setting: Questionnaire Development, Validation, and Application by Lama Soubra (11666333)

“…The secondary aims were to assess the services/interventions in hypertension management that were performed in the real-life setting, as well as the patient satisfaction from these services/interventions.…”

3D printing of circular materials: Comparative environmental analysis of materials and construction techniques by Shoukat Alim Khan (14778226)

“…The study identifies potential "hot spots" of the developed process where environmental impact is highest and develops strategies to reduce or mitigate negative impacts. Life Cycle Assessment (LCA) was carried out for three cases of CDW-based 3D printed structures, Portland cement-based 3D printed structures, and conventional masonry construction methods and materials, to analyze the environmental impact of CDW-based 3D-printed designs and their comparative analysis. …”

Power Characteristics of Selective Buried Oxide MOSFET by Younis, Dana Tariq

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Dynamic Properties of Water Confined in Graphene-Based Membrane: A Classical Molecular Dynamics Simulation Study by One-Sun Lee (1291293)

“…We also calculated the reorientational correlation time of the water molecules, and we found that the rotational motion of confined water inside the membrane is anisotropic and the reorientational correlation time of confined water is slower than that of bulk water. …”

Mixed siliciclastic-carbonate-evaporite sedimentation in an arid eolian landscape: The Khor Al Adaid tide-dominated coastal embayment, Qatar by John M., Rivers

“…The overall landward increase in salinity is accompanied by a decrease in the diversity of benthic fauna and their skeletal remains. …”
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Influence of direct electric field on PMCG-alginate-based microcapsule by Peter Kasak (1360617)

“…Microcapsules showed swelling and decreasing mechanical properties under the applied electric current, and the microcapsule membrane showed anisotropic swelling on the electrode side. …”

Impaired Liver Size and Compromised Neurobehavioral Activity are Elicited by Chitosan Nanoparticles in the Zebrafish Embryo Model by Haissam Abou-Saleh (497840)

“…Although no single sign of cardiotoxicity was observed upon exposure to 200 mg/L of ChNPs, as judged by heartbeat rate, the corrected QT interval (QTc, which measures the time between the start of the Q wave and the end of the T wave in the heart's electrical cycle), maximum cardiac arrest, and ejection fraction assays, the same dosage elicited the impairment of both liver size (decreased liver size, but without steatosis and lipid yolk retention) and neurobehavioral activity (increased movement under different light conditions). …”

Performance of Membrane Biological Reactor for Tobacco Wastewater Treatment by Alhajar, Abdallah Hazim Abdallah

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Modeling the influence of daily temperature and precipitation extreme indices on vegetation dynamics in Katsina State using statistical downscaling model (SDM) by Mohammad, Hadi Ahmad

“…All the scenarios present increasing minimum and maximum temperatures and decreasing precipitation, except for RCP8.5, which predicted a more adverse trend. …”
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A BRET-based Mpro biosensor containing a nanobody and tandem cleavage sites shows an increased cleavage rate by Geethakumari, Anupriya M

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Exploring Unique Physiological and Genetic Features of Desert-dwelling Legumes by Madhurima Chatterjee (5331215)

“…However, recent climatic disasters and civilization practices are deteriorating the soil quality and vegetative lands, resulting in decreased plant growth and yield, negatively affecting human health and dietary habits. …”