Modulation of SLFN11 induces changes in DNA Damage response in breast cancer حسب Christophe Michel Raynaud (17449906)

"…Finally, as a definitive and specific way to modulate SLFN11 expression we implemented SLFN11 dCas9 (dead CRISPR associated protein 9) systems to specifically increase or decrease SLFN11 expression.</p><h3>Results</h3><p dir="ltr">After confirming the previously reported correlation between methylation of SLFN11 promoter and its expression across multiple cell lines, we showed in-vitro that decitabine and IFN-γ could increase moderately the expression of SLFN11 in both BT-549 and T47D cell lines. …"

Intravenous administration of gold nanoparticles in rats exhibit alterations in sphingomyelins, bile acids, sphingolipids, and cholesterol esters levels حسب Haya Al-Sulaiti (5449256)

"…Annotation of metabolites was determined by retention times and specific MRMs for each compound. Results indicate that AuNPs treatment significantly impacted several metabolic pathways. …"

Human Recombinant Arginase I (Co)-PEG5000-Induced Arginine Depletion of Breast Cancer Cell Lines Causes Autophagy Mediated Cell Death حسب Alayan, Moustapha

"…Inhibition of autophagy decreased sensitivity to arginase-induced cytotoxicity in all cell lines, and hence reversed cell death. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Is board compensation excessive? حسب Dah, Mustafa A.

"…Excess compensation declines over our sample period, which may be consistent with increased director workloads as well as increased scrutiny. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Comparison of in-hospital and out-of-hospital cardiac arrest of trauma patients in Qatar حسب Furqan B. Irfan (13359828)

"…IHCAT patients had a greater proportion of anatomically localized injuries indicating solitary injuries compared to greater polytrauma in OHTCA. …"

Phase II National Study: Job Satisfaction and Workplace Environment Among Community Pharmacists in Lebanon: Pre and Post Economic Crisis حسب Salaheddin, Amira Talaat

"…Pharmacists also reported an increase in the frequency of prescription interventions, particularly related to dosage errors and drug-drug interactions, with intervention rates rising from 23.7% in 2016 to 51.1% in 2024. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Effect of methanolic extract of Quercus infectoria bark on blood lipid profile, glycemia, inflammation, platelet aggregation, ulcer and bacterial activity. (c2005) حسب Khouzami, Lara

احصل على النص الكامل
احصل على النص الكامل

Nano-aluminum حسب Doshi, Reeti

"…Concentrations (up to 17 mg/L) far greater than the World Health Organization guideline for Al in drinking water (0.2 mg/L) were measured in columns’ leachates. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

The anti-neoplastic activity of novel platinum II and IV complexes against A549 lung cancer cells حسب Al Sayegh, Rouba

"…While AK1 exhibited faster uptake and greater cytotoxicity, AK2 was by far less toxic to normal mesenchymal stem cells. …"
احصل على النص الكامل
احصل على النص الكامل

Co-occurrence of antibiotic and metal resistance in long-term sewage sludge-amended soils: influence of application rates and pedo-climatic conditions حسب Sonia Mokni-Tlili (20487266)

"…<p dir="ltr">Urban sewage sludge (USS) is increasingly being used as an alternative organic amendment in agriculture. …"

Evaluation of Greywater as a Sustainable Source of Irrigation for Ornamental Crops in Green Walls—A Study of Plant and Soil Using Ruellia tuberosa حسب Shaheeda Marakkar Anangadan (19239607)

"…Greywater irrigation led to greater mineral content in greywater-irrigated plant biomass and soil for all minerals tested, most notably boron, which was deficient in the soil. …"

Retrospective identification of medication related adverse events in the emergency medical services through the analysis of a patient safety register حسب Ian Howard (2026753)

"…Prehospital medication related adverse events remain a significant threat to patient safety in this setting and warrant greater widespread attention and future identification of strategies aimed at their reduction.…"

Strategic and flexible LNG production under uncertain future demand and natural gas prices حسب Noor Yusuf (15748120)

"…This is attributed to the high competitiveness amongst LNG producers and suppliers, providing greater confidence for medium-to-long term demand. …"

Effects of Integrated Project Delivery and Information Communication Technology On Project Success حسب Quadri, Syed Shah Mohiuddin

احصل على النص الكامل

Analysis and Design of Circular Shafts Using Finite Element Method حسب Chehadeh, Ali Saleh

احصل على النص الكامل

Addressing the Overheating Crisis and Its Socio-Economic Implications: A Case Study in London’s High-Risk Areas حسب Maliha, Azra

احصل على النص الكامل
احصل على النص الكامل

Visitors off the trail: Impacts on the dominant plant, bryophyte and lichen species in alpine heath vegetation in sub-arctic Sweden حسب Monika, Rawat

"…Alpine ecosystems are under increasing pressure due to tourism and recreational activities. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Total and segmental liver volume variations حسب Abdalla, Eddie

"…Indeed, improvement in outcome and decrease in complications after extended hepatic resections of increasing complexity have been linked to preservation of adequate functional parenchyma.17 There are few studies in the literature describing the relative contributions of the anatomic hepatic segments to the TLV. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Distribution network line protection in the presence of distributed generation حسب Margossian, Harag

"…The evolution of the distribution network from a passive grid with unidirectional power flows to, in the presence of distributed generation (DGs), an active grid with bidirectional power flows can lead to some technical challenges in its operation as well as some opportunities for greater control and grid support. This dissertation studies the impact of high levels of penetration of DGs into the power system on the operation of distribution network line protection. …"
احصل على النص الكامل
احصل على النص الكامل
احصل على النص الكامل

Nonlinear Control of Brushless Dual-Fed Induction Generator With a Flywheel Energy Storage System for Improved System Performance حسب Mohammed Hamidat (3722086)

"…To optimize parameter tuning within the control system, the Grasshopper Optimization Algorithm (GOA) is applied, ensuring optimal performance of the proposed framework. After optimization, the SMC settling time was significantly reduced from 0.7 seconds to 19.97 milliseconds, achieving a 96.9% improvement in response speed, while its steady-state error decreased from 0.48 to 0.06, marking an 87.5% reduction in tracking error. …"