In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation by Sleiman, Sama F.

“…We observed ATP depletion under OGD vs. hypoxia and propose that ATP depletion enhances translational suppression, overcoming the selective synthesis of HIF concurrent with global decreases in protein synthesis in hypoxia. Taken together, these findings biochemically characterize a practical reporter for monitoring HIF-1α levels and support a novel model for HIF regulation in an in vitro model of human ischemia.…”
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Non-Isolated DC–DC Power Converter With High Gain and Inverting Capability by Mohammad Meraj (16855401)

“…To reduce the ripple in the input current with simultaneous decreasing the input current ripple, a novel current fed interleaved high gain converter is proposed by utilizing the interleaved front-end structure and Cockcroft Walton (CW)-Voltage Multiplier (VM). …”

Essays on international environmental policy by Marrouch, Walid

“…I find that these negative spillovers can potentially neutralize the perverse free riding incentives and as such sustain larger environmental coalitions. …”
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Novel proteins implicated in lipid metabolism disorders by Nature Research (16552612)

“…</p><p>ANGPTL4 is a protein that is activated during fasting, decreasing the release of free fatty acids from circulating triglyceride-rich lipoproteins. …”

Maternal Body Mass Index and Recommended Gestational Weight Gain in a Middle Eastern Setting by Tawa Olukade (11619453)

“…</p><h3>Results</h3><p dir="ltr">The mean maternal age was 29.7 ± 5.5 years, prepregnancy BMI was 27.5 ± 5.8 kg/m2, GWG was 9.58 kg ± 6.87 kg and gestational age at birth was 38.5 ± 1.9 weeks. In line with IOM recommendations, we found that higher BMI was correlated with decreased GWG and BMI was significantly associated with GWG even after adjusting for maternal age, parity, and infants’ gestational age at birth. …”

The molecular mechanisms of apoptosis accompanied with the epigenetic regulation of the NY-ESO-1 antigen in non-small lung cancer cells treated with decitabine (5-aza-CdR) by Varghese P. Inchakalody (14557382)

“…Therefore, we investigated the molecular mechanisms accompanied with the epigenetic regulation of NY-ESO-1 in 5-Aza-CdR-treated NCI–H1975 cell line. We showed significant induction of the NY-ESO-1 protein (**p < 0.0097) using Cellular ELISA. …”

Phase state of secondary organic aerosol in chamber photo-oxidation of mixed precursors by Yu Wang (12152)

“…Although less important than RH and MR_org/inorg, the SOA composition plays a second-order role, with differences in the liquid-to-nonliquid transition at moderate MR_org/inorg of ∼ 1 observed between biogenic-only (anthropogenic-free) and anthropogenic-containing VOC systems. Considering the combining role of the RH and chemical composition in aerosol phase state, the BF decreased monotonically with increasing hygroscopic growth factor (GF), and the BF was ∼ 0 when GF was larger than 1.15. …”

Evaluation of The Factors Affecting Microplastics and Nanoparticles in Plastic Water Supply Pipes by Hammodat, Amina Rayan

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STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration by Ayat S. Hammad (9592374)

“…SOCE has been shown to be important for breast cancer cell migration where knockdown of SOCE components (STIM1 or Orai1) decreases cancer metastasis. Here we show unexpectedly that complete knockout of STIM1 (STIM1-KO) using gene editing in metastatic MDA-MB-231 breast cancer cells results in faster migration and enhanced invasion capacity. …”

Long non-coding RNA MALAT1 promotes steatosis in HepG2 cells by modulating target gene expression in presence of Exendin-4 by Olfa Khalifa (10914452)

“…</p> <p>Results: Treatment with 200nM Ex-4 for 3h decreased the OA-induced lipid buildup significantly (p<0.05). …”

Part II.: Dissimilar friction stir welding of nickel titanium shape memory alloy to stainless steel – microstructure, mechanical and corrosion behavior by Parker West (17268946)

“…The macrostructure of the dissimilar weld showed some surface tunneling defects but there were regions of the weld that were defect free and without evidence of intermetallics at the interface. …”

Comprehensive Transcriptome and Pathway Analyses Revealed Central Role for Fascin in Promoting Triple-Negative Breast Cancer Progression by Rayanah Barnawi (8737584)

“…Herein, fascin ShRNA was used to generate stable fascin knockdown (FSCN1^KD) in the MDA-MB-231 TNBC cell line and then were subjected to comprehensive mRNA and miRNA transcriptome analysis. …”

Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot study by Stefanos Volianitis (22155835)

“…Among the 14 amino acids measured, glutamate was released in the liver, while the uptake of free fatty acids decreased. During exercise at relatively low workloads, arterial lactate and ammonia levels were comparable to those seen in healthy subjects at higher workloads, while euglycemia was maintained due to sufficient hepatic glucose production. …”

Zirconium Phosphate/Ionic Liquid Proton Conductors for High Temperature Fuel Cell Applications by Mohammed, Hanin

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Rapid mercury removal using living indigenous microalgal communities for water treatment applications by Amr Nasr Fekry (22521185)

“…Comprehensive isotherm analysis revealed the Dubinin-Radushkevich model provided the best fit (R² = 0.998), indicating physical adsorption as the predominant mechanism, as the calculated mean free energy (E = 5.00 kJ/mol) falls within the 1–8 kJ/mol range characteristic of physical adsorption. …”

The Effect of High Dose Isoflavone Supplementation on Serum Reverse T3 in Euthyroid Men With Type 2 Diabetes and Post-menopausal Women by Thozhukat Sathyapalan (704787)

“…Thyroid stimulating hormone (TSH) serum concentrations increased while free thyroxine (fT₄) concentrations decreased with 3 months of SPI compared to SP supplementation for both men and women. rT₃ correlated with TSH in both studies (<i>p</i> = 0.03) but not with either fT₃ or fT₄. fT₃ levels did not differ between the SPI and SP preparations.…”

Caloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice by Charlotte Rinne (18766966)

“…Cortical bone, however, was decreased in young mice on CR and remained reduced in aged mice, irrespective of dietary intervention. …”

Chronic reduction of store operated Ca²⁺ entry is viable therapeutically but is associated with cardiovascular complications by Fang Yu (156838)

“…They further establish the SOCE hypomorph line as a genetic model to define the therapeutic window of SOCE inhibition and dissect toxicities associated with chronic SOCE inhibition in a tissue-specific fashion.…”

Effectiveness of Intravenous Iron Therapy in the Management of Severe Iron Deficiency Anemia: A Retrospective Study by Obaidullah Zafar (17910572)

“…These findings highlight the need for individualized IV iron therapy as a first-line treatment in young healthy patients to improve outcomes and optimize healthcare resources.…”

Breaking the barriers towards large-scale microalgae-based bio-hydrogen production by Isra Koko (22631396)

“…Results showed that cultivation dominates the process cost: typical biomass costs are $3.54–$5.78/kg in tubular PBRs versus $3.42–$4.13/kg in ORPs; an automation/modularization case decreased microalgae production cost from $89 to $16/kg at ∼200 t/yr. …”