Modulation of SLFN11 induces changes in DNA Damage response in breast cancer by Christophe Michel Raynaud (17449906)

“…Finally, as a definitive and specific way to modulate SLFN11 expression we implemented SLFN11 dCas9 (dead CRISPR associated protein 9) systems to specifically increase or decrease SLFN11 expression.</p><h3>Results</h3><p dir="ltr">After confirming the previously reported correlation between methylation of SLFN11 promoter and its expression across multiple cell lines, we showed in-vitro that decitabine and IFN-γ could increase moderately the expression of SLFN11 in both BT-549 and T47D cell lines. …”

Assessing Struvite Formation Potential at Wastewater Treatment Plants by Fattah, Kazi Parvez

“…The three locations investigated all has a supersaturation value greater than unity; this indicated that struvite formation potential was high. …”
Get full text

Effectiveness of Positron Emission Tomography for Predicting Chemotherapy Response in Colorectal Cancer Liver Metastases by Glazer, Evan

“…For example, a few years ago an extrahepatic metastasis effectively eliminated surgical resection, but a combination of chemotherapeutic options and surgical techniques has expanded the indications for resection and increased the population of patients who may benefit.1,2 Neoadjuvant chemotherapy has increased the resectability rate by 11% to 37%.1 Unfortunately, greater than 80% of patients undergoing hepatic resection will have recurrences, mostly within the first 2 years.2 Nonetheless, the only hope for cure is resection, and prior surgical dogma based on the number of lesions, size of the tumor-free resection margin, and presence of resectable extrahepatic disease must be questioned.3- 5 The current standard approach to surgical planning is contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) for specific tumor characteristics or contraindications to CT.6 Several series showed that focal extrahepatic disease, an isolated pulmonary lesion, can be safely resected, with 5-year survival rates of 29% to 58%.7,8 In 1 series,7 17 of 30 patients required 3 or more resections. …”
Get full text
Get full text
Get full text

Novel paclitaxel formulations solubilized by parenteral nutrition nanoemulsions for application against glioma cell lines by Najlah, Mohammad

“…Similarly, the droplet size of Intralipid increased from 283.3 to 294.6nm on inclusion of 6mg/ml paclitaxel. …”
Get full text
Get full text
Get full text

Bevacizumab and neovascular age related macular degeneration by El Mollayess, Georges

“…The mean number of letters gained, decrease in CRT, and number of injections were 8 letters, 125.3 µm, and 4.3 injections, respectively. …”
Get full text
Get full text
Get full text
Get full text

Anterior ankle impingment syndrome is less frequent, but associated with a longer absence and higher re-injury rate compared to posterior syndrome: a prospective cohort study of 67... by Pieter D’Hooghe (3530984)

“…AAIS and PAIS were similar regarding injury characteristics except for a greater proportion of AAIS having a gradual onset (69% vs.47%; P = 0.03) and being re-injuries (31% vs. 9%; P = 0.01). …”

Storage allocation for diverse FPGA memory specifications by Ouaiss, Iyad

Get full text
Get full text
Get full text
Get full text

Violent Extremism Prevention in the Era of Globalization by Safieddine, Line Abbas

“…The significance of the study stems from the fact that global strategizing efforts are needed to pay greater emphasis on the media and finance, specifically in weak and vulnerable states. …”
Get full text
Get full text
Get full text

Acute pain management and assessment by Zeitoun, Abeer A.

“…Furthermore, as pain severity scores increased, the adequacy of pain management decreased. Only 22% of the patients had a daily follow-up, and the majority of those continued to receive inappropriate therapy. …”
Get full text
Get full text
Get full text

Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment by Amal Sabouni (17046236)

“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. …”

Redox Homeostasis and Inflammation Responses to Training in Adolescent Athletes: a Systematic Review and Meta-analysis by Evdokia Varamenti (8154642)

“…From those articles, 27 were included in the quantitative analysis (meta-analysis) as their results could be converted into common units.</p><h3>Results</h3><p dir="ltr">Following a short training session or performance test, an extremely large increase in protein carbonyls (PC) (ES 4.164; 95% CI 1.716 to 6.613;Z= 3.333,<i>p</i>= 0.001), a large increase in thiobarbituric acid reactive substances (TBARS) (ES 1.317; 95% CI 0.522 to 2.112;<i>Z</i>= 3.247,<i>p</i>= 0.001), a large decrease in glutathione (GSH) (ES − 1.701; 95% CI − 2.698 to − 0.705;<i>Z</i>= − 3.347,<i>p</i>= 0.001), and a moderate increase of total antioxidant capacity (TAC) level (ES 1.057; 95% CI − 0.044 to 2.158;<i>Z</i>= 1.882, <i>p</i>= 0.060) were observed. …”

COPE for adolescent Syrian refugees in Lebanon: a brief cognitive–behavioral skill-building intervention to improve quality of life and promote positive mental health by Doumit, Rita

“…Lebanon has the highest per-capita concentration of refugees worldwide. …”
Get full text
Get full text
Get full text
Get full text

Full Film, Boundary Lubrication and Tribochemistry in Steel Circular Contacts Lubricated with Glycerol by Habchi, W.

Get full text
Get full text
Get full text

Self-Reported Sleep and Exercise Patterns in Patients with Schizophrenia: a Cross-Sectional Comparative Study by Nancy Kiwan (12451992)

“…Arabic versions of sleep, exercise, socio-demographic, and clinical questionnaires were administered as well as the validated scales to measure psychopathology, depression, and suicidality in these participants.</p><h3>Results</h3><p dir="ltr">The majority of patients with schizophrenia slept more than 8 h per day and exercised less when compared with controls. …”

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... by Alize J, Ferrari

“…Globally between 2010 and 2021, the age-standardised DALY rates for HIV/AIDS decreased by 47·8% (43·3–51·7) and for diarrhoeal diseases decreased by 47·0% (39·9–52·9). …”
Get full text
Get full text
Get full text

Barriers facing self-employed women. (c2007) by Issa, Sendrella

Get full text
Get full text
Get full text

Earthcasting: Geomorphic Forecasts for Society by Tejedor, Alejandro

“…The importance of geomorphic forecasts has never been greater, as technological development and global climate change threaten to reshape the landscapes that support human societies and natural ecosystems. …”
Get full text

Congenital melanocytic nevi by Tannous, Zeina S.

“…Giant congenital melanocytic nevi are associated with an increased risk of the development of melanoma. On the other hand, there is evidence of an increased melanoma risk in patients with small congenital nevi. …”
Get full text
Get full text
Get full text
Get full text

Hybrid effect of carbon nanotubes and polypropylene microfibers on fire resistance, thermal characteristics and microstructure of cementitious composites by Mohammad R., Irshidat

“…The improvement was less significant in the case of exposure temperatures greater than melting point of the fibers. Thermal conductivity of cement mortar is increased by the addition of the CNTs but not the PP fibers for all heating levels. …”
Get full text
Get full text
Get full text

Sustainable Concrete Mix Design: Experimental Study of Life-Size Columns by Abboud, Steven G.

“…This study addresses the use of a unique 3-part substation made from those materials, as well as the life-sizing of Sustainable mixes, which is not highlighted in previous research. …”
Get full text
Get full text
Get full text