Modulation of SLFN11 induces changes in DNA Damage response in breast cancer by Christophe Michel Raynaud (17449906)

“…Finally, as a definitive and specific way to modulate SLFN11 expression we implemented SLFN11 dCas9 (dead CRISPR associated protein 9) systems to specifically increase or decrease SLFN11 expression.</p><h3>Results</h3><p dir="ltr">After confirming the previously reported correlation between methylation of SLFN11 promoter and its expression across multiple cell lines, we showed in-vitro that decitabine and IFN-γ could increase moderately the expression of SLFN11 in both BT-549 and T47D cell lines. …”

Assessing Struvite Formation Potential at Wastewater Treatment Plants by Fattah, Kazi Parvez

“…The three locations investigated all has a supersaturation value greater than unity; this indicated that struvite formation potential was high. …”
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Mixed siliciclastic-carbonate-evaporite sedimentation in an arid eolian landscape: The Khor Al Adaid tide-dominated coastal embayment, Qatar by John M., Rivers

“…These offshore-migrating eolian-derived sediments are being redistributed by tidal currents in an otherwise low-energy coastal zone, where in situ formation of carbonate mud and a low-diversity skeletal assemblage is ongoing within salinity-restricted environments. Three depositional sectors are delineated: 1) an energetic, linear, fault-controlled Entrance Channel into which the eolian dunes spill directly; 2) a relatively deep (up to 20 m) Outer Lagoon, interpreted to represent a flooded karst-collapse structure; and 3) a sprawling, low-energy, shallow (<2 m) Inner Lagoon occupying low-lying areas between deflated eolian dunes.Physical oceanographic modeling, integrating multi-seasonal current meter and tidal gage measurements, demonstrates tidal current flow velocities are relatively high in both the Entrance Channel and at the constricted entrance to the Inner Lagoon. …”
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Effectiveness of Positron Emission Tomography for Predicting Chemotherapy Response in Colorectal Cancer Liver Metastases by Glazer, Evan

“…For example, a few years ago an extrahepatic metastasis effectively eliminated surgical resection, but a combination of chemotherapeutic options and surgical techniques has expanded the indications for resection and increased the population of patients who may benefit.1,2 Neoadjuvant chemotherapy has increased the resectability rate by 11% to 37%.1 Unfortunately, greater than 80% of patients undergoing hepatic resection will have recurrences, mostly within the first 2 years.2 Nonetheless, the only hope for cure is resection, and prior surgical dogma based on the number of lesions, size of the tumor-free resection margin, and presence of resectable extrahepatic disease must be questioned.3- 5 The current standard approach to surgical planning is contrast-enhanced computed tomography (CT) or magnetic resonance imaging (MRI) for specific tumor characteristics or contraindications to CT.6 Several series showed that focal extrahepatic disease, an isolated pulmonary lesion, can be safely resected, with 5-year survival rates of 29% to 58%.7,8 In 1 series,7 17 of 30 patients required 3 or more resections. …”
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Novel paclitaxel formulations solubilized by parenteral nutrition nanoemulsions for application against glioma cell lines by Najlah, Mohammad

“…Similarly, the droplet size of Intralipid increased from 283.3 to 294.6nm on inclusion of 6mg/ml paclitaxel. …”
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Anterior ankle impingment syndrome is less frequent, but associated with a longer absence and higher re-injury rate compared to posterior syndrome: a prospective cohort study of 67... by Pieter D’Hooghe (3530984)

“…AAIS and PAIS were similar regarding injury characteristics except for a greater proportion of AAIS having a gradual onset (69% vs.47%; P = 0.03) and being re-injuries (31% vs. 9%; P = 0.01). …”

Storage allocation for diverse FPGA memory specifications by Ouaiss, Iyad

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Violent Extremism Prevention in the Era of Globalization by Safieddine, Line Abbas

“…The significance of the study stems from the fact that global strategizing efforts are needed to pay greater emphasis on the media and finance, specifically in weak and vulnerable states. …”
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Indomethacin as a Rescue Therapy for Patent Ductus Arteriosus in Extremely Premature Infants after Failed Ibuprofen Treatment by Amal Sabouni (17046236)

“…While most PDAs close after one 3-day course of either medicine, a repeat course may be necessary before considering surgical ligation for those who remain with hsPDAs. …”

Full Film, Boundary Lubrication and Tribochemistry in Steel Circular Contacts Lubricated with Glycerol by Habchi, W.

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Self-Reported Sleep and Exercise Patterns in Patients with Schizophrenia: a Cross-Sectional Comparative Study by Nancy Kiwan (12451992)

“…Arabic versions of sleep, exercise, socio-demographic, and clinical questionnaires were administered as well as the validated scales to measure psychopathology, depression, and suicidality in these participants.</p><h3>Results</h3><p dir="ltr">The majority of patients with schizophrenia slept more than 8 h per day and exercised less when compared with controls. …”

Barriers facing self-employed women. (c2007) by Issa, Sendrella

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Earthcasting: Geomorphic Forecasts for Society by Tejedor, Alejandro

“…The importance of geomorphic forecasts has never been greater, as technological development and global climate change threaten to reshape the landscapes that support human societies and natural ecosystems. …”
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Implementation of corporate governance rules and procedures in lebanese firms by Elgammal, Walid

“…This leads to a serious problem which is the lack of knowledge and awareness of the advantages of corporate governance in such economies. Thus, there is a need to understand the framework and implementation of corporate governance in developing/emerging countries. …”
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Congenital melanocytic nevi by Tannous, Zeina S.

“…Giant congenital melanocytic nevi are associated with an increased risk of the development of melanoma. On the other hand, there is evidence of an increased melanoma risk in patients with small congenital nevi. …”
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Hybrid effect of carbon nanotubes and polypropylene microfibers on fire resistance, thermal characteristics and microstructure of cementitious composites by Mohammad R., Irshidat

“…The improvement was less significant in the case of exposure temperatures greater than melting point of the fibers. Thermal conductivity of cement mortar is increased by the addition of the CNTs but not the PP fibers for all heating levels. …”
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Sustainable Concrete Mix Design: Experimental Study of Life-Size Columns by Abboud, Steven G.

“…This study addresses the use of a unique 3-part substation made from those materials, as well as the life-sizing of Sustainable mixes, which is not highlighted in previous research. …”
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Notes total mesorectal excision (TME) for patients with rectal neoplasia by Chouillard, E.

“…This approach may lead to reduced postoperative pain, decreased hernia formation and improved cosmesis when compared to standard laparoscopy. …”
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Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants by Bin, Zhou

“…Global age-standardised mean systolic blood pressure in 2015 was 127·0 mm Hg (95% credible interval 125·7–128·3) in men and 122·3 mm Hg (121·0–123·6) in women; age-standardised mean diastolic blood pressure was 78·7 mm Hg (77·9–79·5) for men and 76·7 mm Hg (75·9–77·6) for women. …”
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Modulation of Chronic Stress Outcomes by Dietary Sweeteners: A Comparative Study of Sucrose and Aspartame in Mice by Akil, Shaymaa

“…Method: Female C57BL/6J mice (n > 275, aged 8–10 weeks) were given plain water, 12.3% sucrose, or 0.03% aspartame for two weeks, then half of each group underwent a 3-week chronic variable stress (CVS) protocol using mild unpredictable stressors. …”
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