mTORC1 loss impairs epidermal adhesion via TGF-b/Rho kinase activation by Georgess, Dan

“…Despite its central position in oncogenic intracellular signaling networks, the role of mTORC1 in epithelial development has not been studied extensively in vivo. Here, we have used the epidermis as a model system to elucidate the cellular effects and signaling feedback sequelae of mTORC1 loss of function in epithelial tissue. …”
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Distribution of Doxorubicin in Rats Undergoing Ultrasonic Drug Delivery by Staples, Bryant J.

“…Ultrasound (US) increases efficacy of drugs delivered from micelles, but the pharmacokinetics have not been studied previously. In this study, US was used to deliver doxorubicin (Dox) sequestered in micelles in an in vivo rat model with bilateral leg tumors. …”
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Oxandrolone Treatment in Adults with Severe Thermal Injury by Btaiche, Imad F.

“…Oxandrolone, a synthetic derivative of testosterone, has been used in adult patients with severe thermal injury to enhance lean body mass accretion, restore body weight, and accelerate wound healing. …”
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α-ketoglutarate (αKG) acts as a protective factor against chronic stress and has antidepressant properties by modulating BDNF levels in the brain by Eid, Fady

“…In the hippocampus, aKG increases BDNF levels possibly through the PGC1a-BDNF pathway. In the NAc, aKG decreases BDNF levels possibly through the FNDC5-BDNF pathway.…”
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Reduced graphene aerogels as energy efficient selective oil sorbents by Junaid Saleem (14670322)

“…The presence of H₂ significantly decreased the oxygen-containing functional groups in graphene aerogel. …”

Conflict in Ukraine and the unsettling ripples: implications on food systems and development in North Africa by Tarek Ben Hassen (15742605)

“…The findings indicate that food systems in North Africa have been particularly affected by the conflict in Ukraine, owing to its influence on the global economy, trade dynamics, and food prices. …”

The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms by Farah Karam (22330564)

“…While the incidence and mortality of CRC have decreased overall due to better screening, rates in adults under 50 have risen. …”

Enhancing the electrocoagulation process for harvesting marine microalgae (Tetraselmis sp.) using interdigitated electrodes by Wardan A. Khatib (17302747)

“…<p dir="ltr">Marketable value of algal biomass has been increasing in recent years due to its wide range of applications. …”

Fluid-Structure-Acoustic coupling analysis for external laminar and turbulent fluid flows by Tohid Adibi (17871551)

“…However, the effect of a rib and elastic plate on the acoustic properties of a channel for a wide range of Reynolds numbers has not yet been investigated, although their use could reduce noise pollution. …”

Effects of Operating Conditions on Water Absorption Capacity of Superabsorbent Hydrogels by Abdelwahab, Noun

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Developing a Stochastic Model to Predict Cost Overrun due to the Causes of Projects Delay in Oil Fields Construction Industry by ALKHOORI, KHALID ABDUL MAJEED

“…The criticality of managing projects delay in oil fields construction projects has been exacerbated by the general complexities associated with the sources of projects delay and how varied the impact may be to various stakeholders such as client/owner, contractor, design/consultant and miscellaneous/external groups within the industry. …”
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To What Extent is Humanistic Language Teaching Incorporated in the Instructional Practices of the Foundation Teachers in Higher Colleges of Technology (HCT)-Fujairah, UAE? A Case S... by Abu Khait, Baha Eddin Hussein Shukri

“…The participants were also convinced that incorporating HLT in the Foundation context was beneficial to learners as it decreased learning anxiety and helped them become more engaged in learning. …”
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Graph-Guided Regularized Regression of Pacific Ocean Climate Variables to Increase Predictive Skill of Southwestern U.S. Winter Precipitation by Tejedor, Alejandro

“…Recently, promising data-driven approaches have been proposed, but they often suffer from overparameterization and overfitting due to the short observational record, and they often do not account for spatiotemporal dependencies among covariates (i.e., predictors such as sea surface temperatures). …”
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Genotypic and phenotypic characterization of Candida albicans Lebanese hospital isolates resistant and sensitive to caspofungin by Toutounji, Maggie

“…Caspofungin sensitive strains showed decreased resistance to Congo red yet increased virulence and biofilm formation. …”
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LDL-C Targets in Secondary Prevention: How Low Should We Go? by Karim Bayoumy (3496688)

“…<h3>Abstract</h3><p dir="ltr">The benefits of lowering low-density lipoprotein cholesterol (LDL-C), mainly using high-intensity statin therapy, and its impact on decreasing the recurrence of atherosclerotic cardiovascular disease (ASCVD) in secondary prevention has been well established. …”

Role of two efflux proteins, ABCB1 and ABCG2 in blood-brain barrier transport of bromocriptine in a murine model of MPTP-induced dopaminergic degeneration by Milane, Aline

“…Cerebral drug transport by ABC transporters in MPTP models has never been reported. Methods: We have investigated the transport of bromocriptine through the blood-brain barrier (BBB) in a MPTP model to understand the influence of the dopaminergic degeneration on ABCB1 and ABCG2. …”
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Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2... by Michael, Brauer

“…For younger demographics (ie, those aged 0–4 years and 5–14 years), risks such as low birthweight and short gestation and unsafe water, sanitation, and handwashing (WaSH) were among the leading risk factors, while for older age groups, metabolic risks such as high SBP, high body-mass index (BMI), high FPG, and high LDL cholesterol had a greater impact. From 2000 to 2021, there was an observable shift in global health challenges, marked by a decline in the number of all-age DALYs broadly attributable to behavioural risks (decrease of 20·7% [13·9–27·7]) and environmental and occupational risks (decrease of 22·0% [15·5–28·8]), coupled with a 49·4% (42·3–56·9) increase in DALYs attributable to metabolic risks, all reflecting ageing populations and changing lifestyles on a global scale. …”
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A positive change in energy balance modulates TrkB expression in the hypothalamus and nodose ganglia of rats by Zeeni, Nadine

“…Furthermore, treatment with BDNF has been found to attenuate weight gain or even cause weight loss and appetite suppression in rats. …”
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Effect of structural remodeling (retraction and recoil) of the pipeline embolization device on aneurysm occlusion rate by Jou, L.-D.

“…RESULTS: Structural changes of the device have been observed, and it was found that the Pipeline Embolization Device influences the vessel curvature in some cases. …”
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In-Vitro Degradation of Hollow Silica Reinforced Magnesium Syntactic Foams in Different Simulated Body Fluids for Biomedical Applications by Manakari, Vyasaraj

“…Further, the effect of corrosive environment on the degradation behaviour of Mg has been elucidated.…”
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