Cytotoxicity of Arginine Deprivation to AML Cells is Mediated by Autophagy by Taki, Fatima

“…[HuArgI(Co)-PEG5000]-induced arginine deprivation led to significant and sustained activation of autophagy starting at 24 hours and lasting up to 120 hours following arginine deprivation in all cell lines. Inhibition of autophagy, using chloroquine, led to a significant decrease in cell cytotoxicity evident at 48 hours and up to 120 hours. …”
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Loss of FOXA2 induces ER stress and hepatic steatosis and alters developmental gene expression in human iPSC-derived hepatocytes by Maryam Aghadi (17128819)

“…Here, we used FOXA2−/−iPSC lines to understand the role of FOXA2 on the development and function of human hepatocytes. …”

Country of birth affects blood pressure in the French hypertensive diabetic population by Bahous, Sola Aoun

“…The combination of diabetes and hypertension in African populations was associated with increased aortic stiffness and PP, together with greater body weight and WHR. …”
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Global, regional, and national burden of upper respiratory infections and otitis media, 1990–2021: a systematic analysis from the Global Burden of Disease Study 2021 by Sirota, Sarah Brooke

“…The global all-age incidence rate of URIs decreased by 10·1% (–12·0 to –8·1) from 1990 to 2019. …”
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Notes total mesorectal excision (TME) for patients with rectal neoplasia by Chouillard, E.

“…This approach may lead to reduced postoperative pain, decreased hernia formation and improved cosmesis when compared to standard laparoscopy. …”
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STIM1 signals through NFAT1 independently of Orai1 and SOCE to regulate breast cancer cell migration by Ayat S. Hammad (9592374)

“…In contrast, Orai1-KO cells, which have similar levels of SOCE inhibition as STIM1-KO, migrate slower than the parental cell line. This shows that the enhanced migration phenotype of STIM1-KO cells is not due to the loss of Ca²⁺ entry through SOCE, rather it involves transcriptional remodeling as elucidated by RNA-seq analyses. …”

Coats disease in Saudi Arabia by Alqahtani, Abdullah A.

“…The reason for presentation was decreased vision in 11 cases (55 %), strabismus in 4 (20 %), leukocoria in 2 (10 %), and others in 3 (15 %) . …”
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From metabolic dysregulation to neurodegenerative pathology: the role of hyperglycemia, oxidative stress, and blood-brain barrier breakdown in T2D-driven Alzheimer’s disease by Ahmad Raza (18205961)

“…<p dir="ltr">Type 2 Diabetes (T2D) and Alzheimer’s Disease (AD) share common risk factors that can be seen through T2D nearly doubling an individual’s likelihood of developing AD. …”

Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot study by Stefanos Volianitis (22155835)

“…Among the 14 amino acids measured, glutamate was released in the liver, while the uptake of free fatty acids decreased. During exercise at relatively low workloads, arterial lactate and ammonia levels were comparable to those seen in healthy subjects at higher workloads, while euglycemia was maintained due to sufficient hepatic glucose production. …”

3D Tissue-Engineered Vascular Drug Screening Platforms: Promise and Considerations by Isra Marei (11312895)

“…<p dir="ltr">Despite the efforts devoted to drug discovery and development, the number of new drug approvals have been decreasing. Specifically, cardiovascular developments have been showing amongst the lowest levels of approvals. …”

Impact of the fear of Covid-19 infection on intent to breastfeed; a cross sectional survey of a perinatal population in Qatar by Shuja Mohd Reagu (12051406)

“…Obsessive–compulsive symptoms were not significantly correlated with intent to breastfeed and can be seen as adaptive strategies utilized by women to continue breastfeeding in the context of fear of infection.…”

Numerical Investigation of Flexural Behavior of Reinforced Concrete (RC) T-Beams Strengthened with Pre-Stressed Iron-Based (FeMnSiCrNi) Shape Memory Alloy Bars by Khalil, Ahmed

“…Based on the numerical results, it was found that increasing the compression strength from 30 to 60 MPa slightly improves the beam’s strength (by 2%), but it significantly increases its ductility by approximately 45%. …”
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The global, regional, and national burden of stomach cancer in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease study 2017 by Arash Etemadi (330880)

“…The highest age-standardised incidence rates in 2017 were seen in the high-income Asia Pacific (29·5, 28·2–31·0 per 100 000 population) and east Asia (28·6, 27·3–30·0 per 100 000 population) regions, with nearly half of the global incident cases occurring in China. …”

Longitudinal Study of Hypertensive Subjects With Type 2 Diabetes Mellitus by Bahous, Sola Aoun

“…Mortality was significantly greater among diabetic than nondiabetic hypertensive subjects (all-cause mortality, 14.05% versus 7.43%; and cardiovascular mortality, 1.28% versus 0.7%). …”
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Five-Level MLI-Based Grid-Connected Photovoltaic Systems: A Review on Control Methodologies, Modulation Strategies and Recent Developments by Anurag Tiwari (3563561)

“…Five-level MLI-based PV systems have become a crucial option as the relevance of renewable energy keeps increasing because of their increased efficiency, less harmonic distortion, and greater power quality. …”

Impacts of Diverse Workforce on Cyber Security and Information Technology Management by ALHEBSI, WADDAH SULTAN

“…Despite these findings, organizations should continue to consider the potential benefits of diversity in the cybersecurity workforce, including improved decision-making, increased adaptability, enhanced creativity, greater representation, and improved team performance. …”
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Fixed-interval versus OCT-guided variable dosing of intravitreal bevacizumab in the management of neovascular age-related macular degeneration by El-Mollayess, Georges M.

“…Similarly, CRT decreased after 12 months by 80.7 μm for variable dosing vs 100.5 μm for fixed-interval dosing (P = .37). …”
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Daucus carota Pentane-Based Fractions Suppress Proliferation and Induce Apoptosis in Human Colon Adenocarcinoma HT-29 Cells by Inhibiting the MAPK and PI3K Pathways by Shehaby, Wassim N.

“…Western blot revealed the activation of caspase-3, PARP cleavage, and a considerable increase in Bax and p53 levels, and a decrease in Bcl-2 level. Treatment of HT-29 cells with either fraction markedly decreased the levels of both phosphorylated Erk and Akt. …”
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Chemopreventive potential of the pentane-based fraction of wild carrot oil against chemically-induced squamous cell carcinoma by Shebaby, W.

“…The fractions were tested in vitro against several cancer cell lines and F1 was found to possess the highest activity. …”
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Effect of StarD13 on colorectal cancer proliferation, motility and invasion by Nasrallah, Anita

“…Colon cancer is a cancer of the epithelial cells lining the colon. It is mainly divided into different stages according to the invasiveness and metastatic ability of the tumor. …”
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