Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss by Meritxell Espino Guarch (18810097)

“…SLC7A8/SLC3A2 heterodimer is a neutral amino acid exchanger. Here, we demonstrated that SLC7A8 is expressed in the mouse inner ear and that its ablation resulted in ARHL, due to the damage of different cochlear structures. …”

Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease by Satra Nim (11540447)

“…<p dir="ltr">Accumulation of α-synuclein into toxic oligomers or fibrils is implicated in dopaminergic neurodegeneration in Parkinson’s disease. Here we performed a high-throughput, proteome-wide peptide screen to identify protein-protein interaction inhibitors that reduce α-synuclein oligomer levels and their associated cytotoxicity. …”

Investigating the structural impacts of a novel missense variant identified with whole exome sequencing in an Egyptian patient with propionic acidemia by Ali Zaki Ibrahim (17092957)

“…<p dir="ltr">Propionic Acidemia (PA) is an inborn error of metabolism caused by variants in the PCCA or PCCB genes, leading to mitochondrial accumulation of propionyl-CoA and its by-products. Here, we report a 2 year-old Egyptian boy with PA who was born to consanguineous parents. …”

Meta-Heuristic Algorithm-Tuned Neural Network for Breast Cancer Diagnosis Using Ultrasound Images by Ahila A (18394806)

“…Early diagnosis is the only way to increase the treatment options which then decreases the death rate and increases the chance of survival in patients. …”

The effects of long-term testosterone treatment on endocrine parameters in hypogonadal men: 12-year data from a prospective controlled registry study by Aksam Yassin (14779204)

“…Whilst the benefits of testosterone (T) replacement are well-evidenced, the long-term data for TTh on metabolic and endocrine parameters is limited. Here we present the effect of TTh on endocrine parameters in hypogonadal men at a 12-year follow-up. …”

CRISPR-Cas Controls Cryptic Prophages by Sooyeon Song (4891132)

“…<div><p>The bacterial archetypal adaptive immune system, CRISPR-Cas, is thought to be repressed in the best-studied bacterium, Escherichia coli K-12. We show here that the E. coli CRISPR-Cas system is active and serves to inhibit its nine defective (i.e., cryptic) prophages. …”

Fibrillar form of α-synuclein-specific scFv antibody inhibits α-synuclein seeds induced aggregation and toxicity by Vijay Gupta (209146)

“…Therefore, the scFvs described here have considerable potential to be utilized towards immunotherapy in synucleinopathies and may also have applications in ante-mortem imaging modalities.…”

The effect of type and combination of fertilizers on eukaryotic microbiome of date palm rhizosphere by Sara H. Al-Hadidi (17821196)

“…<p dir="ltr">The date palm (<i>Phoenix dactylifera</i>) is an important cultivated crop in arid areas. Here, we studied the effect of plant genotype and type of fertilizers on the eukaryotic community structures of the date palm rhizosphere. …”

PGAP3 Associated with Hyperphosphatasia with Mental Retardation Plays a Novel Role in Brain Morphogenesis and Neuronal Wiring at Early Development by Sahar I. Da’as (9631717)

“…<p dir="ltr">Recessive mutations in Post-GPI attachment to proteins 3 (PGAP3) cause the rare neurological disorder hyperphosphatasia with mental retardation syndrome 4 type (HPMRS4). Here, we report a novel homozygous nonsense mutation in PGAP3 (c.265C>T-p.Gln89*), in a 3-year-old boy with unique novel clinical features. …”

Damage and life cycle assessment of new-generation wide-base tires in New Brunswick, Canada. (c2017) by Said, Izak

“…After combining the distresses considered, pavement damage increased as NGWBT market penetration became greater; for a case study with market penetration of 20%, damage increment due to NGWBT increased by 8%. …”
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The effect of ZrOx modification of graphene nanoribbon on its adsorption for NOx: A DFT investigation by Ahmad I. Ayesh (10188469)

“…Herein, the adsorption energy of AGNR doped using ZrO₂ for NO increases 26.9 times while it increases 19.6 times for NO₂ as compared with those of the pure structure. …”

The Efficacy of Lubiprostone in Patients of Constipation: An Updated Systematic Review and Meta‐Analysis by Umar Akram (20151411)

“…<h3>Background and Aim</h3><p dir="ltr">Lubiprostone increases chloride and water secretion in the intestines, and several studies have demonstrated the efficacy of lubiprostone in treating functional constipation. …”

CFD modeling of particle settling in drilling fluids: Impact of fluid rheology and particle characteristics by Abdelrahman M. Awad (16932519)

“…Ellipsoidal cuttings exhibited significantly greater resistance to settling as compared to spherical particles, mainly due to the increased drag force. …”

Anteriolateral versus anterior–posterior electrodes in external cardioversion of atrial fibrillation: A systematic review and meta‐analysis of clinical trials by Karam R. Motawea (13954362)

“…The pooled analysis showed a statistically significant association between anterior–lateral electrode and increased cardioversion rate of AF (odds ratio [OR] = 1.40, 95% confidence interval [CI] = 1.02–1.92, <i>p</i> = .04). …”

The impact of COVID‐19 pandemic lockdown on smoking habits and lifestyle: A cross‐sectional study by Almu'atasim Khamees (11875640)

“…While those who had a decrease in their smoking level experienced a somehow healthier lifestyle regarding nutrition and other aspects.…”

Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection? by Abu Saleh Md Moin (6189512)

“…</p><h3>Conclusion</h3><p dir="ltr">Basal macrophage activation was higher in PCOS with macrophage changes related with increased infection risk associating with vitamin D; all changes were BMI dependent, suggesting that obese PCOS with vitamin D deficiency may be at greater risk of more severe COVID-19 infection, but that it is obesity-related rather than an independent PCOS factor.…”

COVID-19 biomarkers for severity mapped to polycystic ovary syndrome by Abu Saleh Md Moin (6189512)

“…These protein panels target biological processes involved in vessel damage, platelet degranulation, the coagulation cascade and the acute phase response [1], with greater protein changes dependent on the COVID-19 severity. …”

The impact of nozzle diameter and printing speed on geopolymer-based 3D-Printed concrete structures: Numerical modeling and experimental validation by Shoukat Alim Khan (14778226)

“…Findings indicate that an increased nozzle size, reflected in greater layer height and width, positively influences buildability, whereas higher printing speeds correlate with reduced buildability. …”

Designing Low Frequency I.C Filter Using Pseudo Resistor for Biopotential Measurements by Neshatvar, Nazanin

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Solar power forecasting beneath diverse weather conditions using GD and LM-artificial neural networks by Sharma, Neetan

“…Because key factors such as sudden movement of the clouds, instantaneous deviation of temperature in ambiance, the increased proportion of relative humidity and uncertainty in the wind velocities, haziness, and rains cause the undesired up and down ramping rates, thereby affecting the solar power generation to a greater extent. …”
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