Showing 321 - 340 results of 2,767 for search '(( i ((large decrease) OR (larger decrease)) ) OR ( b ((large decrease) OR (larger decrease)) ))', query time: 0.63s Refine Results
  1. 321
  2. 322
  3. 323

    Altered structure and function of human αB-crystallin due to the p.R163C mutation. by Aref Baharvand (21713886)

    Published 2025
    “…This mutant protein tends to form larger oligomers than its wild-type counterpart. Although it exhibits decreased chemical and thermal stability, it demonstrates greater proteolytic stability and shows an increased tendency for fibrillation under thermochemical stress conditions. …”
  4. 324
  5. 325

    Consensus time <i>τ</i> as a function of system size <i>L</i>. by Pratik Mullick (12851011)

    Published 2025
    “…<i>τ</i> decreases for lower values of <i>q</i>, however it does not exhibit a systematic dependence as <i>q</i> is made larger.…”
  6. 326
  7. 327
  8. 328
  9. 329
  10. 330
  11. 331
  12. 332
  13. 333

    Primers and shRNAs. by Huanzhou Xu (8129922)

    Published 2025
    “…Our experiments show that ZC3H18 expression is regulated by the key oncogenic factors STAT3 and MYC, as well as the essential viral protein EBNA1. Using inhibitors and genetic knockdown, we find that suppressing STAT3, MYC, or EBNA1 leads to decreased ZC3H18 levels, reduced cell viability, and increased apoptosis in EBV-positive B lymphoma cells. …”
  14. 334

    Kit-mediated autophagy suppression driven by a viral oncoprotein emerges as a crucial survival mechanism in Merkel cell carcinoma by Hao Shi (158171)

    Published 2025
    “…Thus, autophagy-inducing agents represent a therapeutic strategy in advanced MCPyV-associated MCC.</p> <p><b>Abbreviation</b>: 3-MA, 3-methyladenine; AL, autolysosome; AP, autophagosome; Baf-A1, bafilomycin A<sub>1</sub>; BARA, β-α repeated autophagy specific domain; BH3, BCL2 homology 3 domain; CCD, coiled-coil domain; CHX, cycloheximide; Co-IP, co-immunoprecipitation; CQ, chloroquine; CTR, control; DAPI, 4′,6-diamidino-2-phenylindole; EBSS, Earle’s balanced salt solution; ECD, evolutionarily conserved domain; EEE, three-tyrosine phosphomimetic mutations Y229E Y233E Y352E; ER, endoplasmic reticulum; FFF, three-tyrosine non-phosphomimetic mutations; FFPE, formalin-fixed paraffin-embedded; FL, full-length; GIST, gastrointestinal stromal tumor; IB, immunoblotting; IHC, immunohistochemistry; KIT-HEK293, KIT stably expressing HEK293 cells; KRT20/CK20, keratin 20; LT, large T-antigen; LT339, MCPyV truncated LT antigen; LTco, codon-optimized MCPyV LT antigen; MCC, Merkel cell carcinoma; MCPyV<sup>−</sup>, MCPyV-negative; MCPyV, Merkel cell polyomavirus; MCPyV<sup>+</sup>, MCPyV-positive; PARP1, poly(ADP-ribose) polymerase 1; PCI, pan-caspase inhibitor; PI, propidium iodide; PtdIns3K, class III phosphatidylinositol 3-kinase; PtdIns3P, phosphatidylinositol-3-phosphate; RB1, RB transcriptional corepressor 1; RTKs, receptor tyrosine kinases; KITLG/SCF, KIT ligand; sT, small T-antigen; sTco, codon-optimized MCPyV sT antigen; T-B, Tat-BECN1; T-S, Tat-scrambled; TEM, transmission electron microscopy.…”
  15. 335
  16. 336
  17. 337
  18. 338
  19. 339

    <i>Copia</i> and <i>dArc1</i> have an inverse relationship at the <i>Drosophila</i> NMJ. by P. Githure M’Angale (20746093)

    Published 2025
    “…<p>(A–C) The presynaptic knockdown of <i>Copia</i> with <i>Copia</i><sup>pol</sup>-shRNA (B1B4) and <i>Copia</i><sup>gag</sup>-siRNA (C1–C4) leads to a significant increase in α-dArc1 staining both pre- and postsynaptically at the larval NMJ compared to wild type (A1–A4). …”
  20. 340