Studies of Glyoxalase 1-Linked Multidrug Resistance Reveal Glycolysis-Derived Reactive Metabolite, Methylglyoxal, Is a Common Contributor in Cancer Chemotherapy Targeting the Splic... by Alhujaily, Muhanad

“…Background: Tumor glycolysis is a target for cancer chemotherapy. Methylglyoxal (MG) is a reactive metabolite formed mainly as a by-product in anaerobic glycolysis, metabolized by glyoxalase 1 (Glo1) of the glyoxalase system. …”
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Adaptive thermal comfort in the different buildings of Darjeeling Hills in eastern India – Effect of difference in elevation by Thapa, Samar

“…Thermal comfort standards are required to provide comfortable indoor condition which has a positive effect on the occupant. However, the Predicted Mean Vote – Percentage People Dissatisfied (PMV-PPD) model which is used to determine the indoor comfort in most of the international standards fails often, especially in naturally ventilated buildings. …”
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Experimental analysis of additively manufactured thin-walled heat-treated circular tubes with slits using AlSi10Mg alloy by quasi-static axial crushing test by Mohamed A.S.

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Rhus coriaria induces senescence and autophagic cell death in breast cancer cells through a mechanism involving p38 and ERK1/2 activation by El Hasasna, Hussain

“…We demonstrated that Rhus coriaria ethanolic extract (RCE) inhibits the proliferation of these cell lines in a time- and concentration-dependent manner. RCE induced senescence and cell cycle arrest at G1 phase. …”
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Novel potentials of the DPP-4 inhibitor sitagliptin against ischemia-reperfusion (I/R) injury in rat ex-vivo heart model by Al-Awar A.

“…Sitg oral treatment of different doses (25, 50, 100, and 150 mg/kg/day), or saline as a Control. Hearts were then isolated and subjected to two different I/R injury protocols: 10 min perfusion, 45 min regional ischemia, and 120 min reperfusion for infarct size (IS) measurement, or: 10 min perfusion, 45 min regional ischemia and 10 min reperfusion for biochemical analysis: nitric oxide synthases (NOSs) and DPP-4 activity, glucagon-like peptide-1 (GLP-1), Calcium, transient receptor potential vanilloid (TRPV)-1 and calcitonin gene-related peptide (CGRP) levels, transient receptor potential canonical (TRPC)-1 and e-NOS protein expression. …”
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Study of Magnetic Properties and Lattice Dynamics of the Cdx Co1-x Ferrite System by MossbauerEffect by Eissa, N. A. [نبيل عيسى]

“…The Neel temperature was found to decrease with increasing cadmium concentration. The reduced hyperfine magnetic fields for the A- and the B- sites were found to follow the Brillouin function and One-Third-Power Law. …”
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Proliposome tablets manufactured using a slurry-driven lipid-enriched powders: Development, characterization and stability evaluation by Khan I.

“…Proliposome powders were prepared via a slurry method using sorbitol or D-mannitol as carbohydrate carriers in 1:10 or 1:15 w/w lipid phase to carrier ratios. …”
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The role of type II FB (I):Tl+ defect in laser light generation and color image formation at the low coordination surface sites of AgBr: Ab initio calculations by Shalabi, A.S.

“…All relaxed excited states of the defect containing surfaces were deep below the lower edges of the conduction bands of the ground-state defect-free surfaces indicating that type II FB(I):Tl+ is suitable laser defect. The probability of orientational destruction of the two centers, attributed to the assumed saddle point ion configurations along the 〈1 1 0〉 axis, was found to decrease as the coordination number of the surface ions decreases. …”
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A Model For A Narrow-Cut Fractionating Column by Farag, Hassan A.

“…A mathematical model was developed to simulate the operation of a narrow-cut fractionating column. …”
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Effect of plastic deformation on Corrosion of cadmium in 0.1 m sodium Sulphate solution by Kandeil, A. Y. [عبد الرزاق يوسف قنديل]

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Tailoring optical absorption in silicon nanostructures from UV to visible light: A TDDFT study by Hassan, Walid M.I.

“…Our main findings are that: (i) The oscillator strength as a function of length is quadratic at small lengths, and then increases linearly. …”
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Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2. by P, Sneha

“…Molecular docking analysis revealed a decrease in interaction between the protein and ATP in all the 3 mutations, and molecular dynamic simulations of 50 ns showed a loss of stability and compactness in the mutant proteins. …”
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Towards An Effective Urban Growth Management Strategy In Qatar (1) by Al Thani, F. A. Rahman

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Mossbauer Effect Study of the Cations Distribution and its Influence on the Electric Field Gradient of the Cdx Co1-x Ferrite System by Eissa, N. A. [نبيل عيسى]

“…In the ferrite system Cd,Co,_x Fe; 04 (X=0.0, O.I, 0.2, ....... , 1.0). it was found that the introduction of Co2'1' decrease the EFG at the octahedral B-site. …”
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A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation... by Thirumal Kumar, D

“…The molecular interaction study also revealed that the co-crystallized AKT1 inhibitor N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo [4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide (12j) exhibited a better interaction with native AKT1 compared with the E17K mutant AKT1 protein, whereas, Akti-1/2 exhibited the opposite effects, i.e., a better interaction with the E17K mutant AKT1 than the native AKT1. …”
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Ubiquitin-Related Modifier 1 (URM-1) Modulates Cx43 in Breast Cancer Cell Lines. by El-Hajjar, Layal

“…The significant upregulation of small ubiquitin-like modifier-1 (SUMO-1) was also observed. In cells with downregulated URM-1, Cx43 expression significantly decreased, and SUMOylation by SUMO-1 was affected. …”
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Seismic detection and characterization of a man-made karst analog - A feasibility study by Gritto, Roland

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Heme Oxygenase Isoform 1 Regresses Cardiomyocyte Hypertrophy Through Regressing Sodium Proton Exchanger Isoform 1 Activity by Sobh, Ahmed

“…Results: Our results showed a significant decrease in HO-1 mRNA expression in cardiomyocytes expressing active NHE1 (74.84 ± 9.19 % vs. 100 % normal NHE1 expression, p<0.05). …”
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A Modification to Enhance the Survival of the Island FDMA Flap by Adding a Skin Bridge by Al Lahham, Salim

“…Distal necrosis of the patients in this study patients was compared with that in a control of 10 patients in whom we did the conventional FDMA flap. …”
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Second law analysis of a gravity-driven liquid film flowing along an inclined plate subjected to constant wall temperature by Al-Ahmed, Abdullah I.

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