Molecular and Structural Analysis of Mosaic Variants of Penicillin-Binding Protein 2 Conferring Decreased Susceptibility to Expanded-Spectrum Cephalosporins in <i>Neisseria gonorrh... by Joshua Tomberg (1345956)

“…Transfer of the mosaic <i>penA35</i> allele containing an A501V mutation to FA6140, a chromosomally mediated penicillin-resistant isolate, increased the MICs of ceftriaxone (0.4 μg/mL) and cefixime (1.2 μg/mL) to levels above their respective break points. …”

Absence of PICALM results in a decreased rate of internalization and increased cell surface expression of TfR in MEFs. by Paula B. Scotland (138601)

The <i>P[syt^P-L]</i> mutation decreases the Ca²⁺ affinity of release and vesicular release probability, but the readily releasable pool is unchanged. by Mallory C. Shields (4474210)

“…Scale bar 2mV, 3s. (D) Paired-pulse analysis indicates a decrease in release probability in <i>+/-;P[syt^P-L]/+</i>. …”

Significantly decreased adhesion to host cells by the Δ<i>tad123</i> mutant (A) and time-dependent recovery (B). by Tra-My Duong-Nu (7300970)

Tax expression is associated with decreased cellular motility. by Saumya Ramanayake (7879091)

OCA alone markedly decreases and combined with Gemcitabine or Cisplatin abrogates growth of iCCA xenografts. by S. Di Matteo (6260417)

“…After 4 weeks, when the tumor size was approximately 100 mm³ (T₀) mice were treated with OCA (0.03% w/w, 30 mg/kg) alone or combined with Cisplatin (2.4 mg/Kg in 100 μl) or Gemcitabine (1.05 mg/Kg in 100 μl) for 5 additional weeks. a) Results are expressed as percent increase in tumor volume at different time points. …”

EtOH decreased ΔΨm in a subset of esophageal keratinocytes. by Prasanna M. Chandramouleeswaran (3176268)

V5-SgG2 transfection in the epidermis modifies the termination site of peptidergic FNE. by Jorge Rubén Cabrera (685511)

Subjects:

Dysfunction of <i>ERG251</i> activates a Zinc transporter contributing to decreased azole susceptibility. by Xin Zhou (54275)

Netrin-1 overexpression increases HCV RNA and specific infectivity of HCV virions in vitro whereas Netrin-1 depletion decreases HCV RNA and specific infectivity in vitro. by Marie-Laure Plissonnier (337713)

“…<b>H</b>. Netrin-1 depletion impedes HCV. Huh7.5 cells were transfected with siRNAs, infected at a MOI of 0.1 24 h after seeding, and trypsinized at day five post-infection before a second siRNA transfection. …”

Deletion of TAL does not decrease GNG flux. by Julie Kovářová (4114573)

Deletion of <i>ERG251-A</i> but not <i>ERG251-B</i> leads to decreased filamentation. by Xin Zhou (54275)

Loss of FOXP1 results in decreased number of bRGCs. by Seon Hye E. Park (16765033)

Decrease of SMAD3 protein, but not SMAD2 in DBA iPSCs. by Jingping Ge (636557)

“…The ratio of protein level to WT is labelled under the image. A) No change of mRNA level of <i>SMAD2</i> or <i>SMAD3</i> in the DBA iPSCs with <i>RPS19</i> or <i>RPL5</i> mutations. …”

Packaging of multiple cleavage enzymes that target different HBV regions enhances potency and decreases resistance. by Joshua T. Schiffer (430730)

“…<p>Simulation of HBV eradication employing gene therapy following a single dose. Each data point represents number of remaining infected cells (y-axis) after a simulation with one of 36 unique parameter sets. x-axis is functional multiplicity of infection (fMOI). …”

Vectorized siRNA TMPRSS2-ERG IV-SQ impaired tumour growth and restored differentiation <i>in vivo</i>. by Giorgia Urbinati (554921)

“…<p><b>a.</b> SCID mice (n = 5/group) bearing VCaP tumour xenografts were injected intravenously either with NaCl 0.9%, non-vectorized siRNA TMPRSS2-ERG IV, NPs siRNA control-SQ or NPs siRNA TMPRSS2-ERG IV-SQ twice per week during 6 weeks (1.8 mg/kg/mouse cumulative dose). …”

Treatment with wt- or S360A-(A)PC decreases infarct area. by Karin C. A. A. Wildhagen (599651)

BCG-AS−Ndk has decreased intracellular survival due to increased phagolysosome fusion. by Jim Sun (367834)

Treatment with anti-JAM-C antibody decreases the severity of antigen-induced arthritis by Gaby Palmer (636)

“…Results are expressed as the ratio of technetium-99m (Tc) uptake in the arthritic over the non-inflamed knee. The mean ± standard error of the mean (SEM) of the ratios is shown for anti-JAM-C antibody-treated (= 10 for days 1 and 3, = 6 for day 7; black symbols) and isotype-matched control antibody-treated (= 10 for days 1 and 3, = 5 for day 7; open symbols) mice. …”

CX treatment leads to decreased perfusion and increased leakage after VEGF-A induced angiogenesis. by Mattias Kalén (224600)