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Functional characterization of human myosin-binding protein C3 variants associated with hypertrophic cardiomyopathy reveals exon-specific cardiac phenotypes in zebrafish model
Published 2020“…We investigated the impact of two novel human MYBPC3 splice-site variants: V1: c.654+2_654+4dupTGG targeting exon 5 using morpholino MOe5i5; and V2: c.772+1G'A targeting exon 6 using MOe6i6; located within C1 domain of cMyBP-C protein, known to be critical in regulating sarcomere structure and contractility. …”
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404
Harmed Trait Self-Control: Why Do People with a Higher Dispositional Malicious Envy Experience Lower Subjective Wellbeing? A Cross-Sectional Study
Published 2019“…The main results revealed that: (a) dispositional benign envy positively predicted subjective wellbeing; and (b) dispositional malicious envy negatively predicted subjective wellbeing and that decreased sense of trait self-control accounted for this relationship (full mediation). …”
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Performance Evaluation of A Class of Adaptive Bifurcated Routing Algorithms
Published 1988“…The second one is a deterministic routing algorithm that uses localised deterministic routing decisions based on centralised measures. …”
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407
Towards a simplified technique for crack recognition in gearing systems
Published 2022“…The experimental results obtained from the modal analysis tests confirmed the previously obtained numerical results. A graphical representation of these parameters on a polar plot shows concentric circles with no particular sign from one tooth to another. …”
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408
Divergent Biochemical Properties and Disparate Impact of Arrhythmogenic Calmodulin Mutations on Zebrafish Cardiac Function
Published 2024“…In cardiac muscle, CaM modulates directly or indirectly the activity of several proteins that play a key role in excitation-contraction coupling (ECC), such as ryanodine receptor type 2 (RyR2), l-type Ca2+ (Cav1.2), sodium (NaV1.5) and potassium (KV7.1) channels. …”
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409
A thermodynamic study of propanol reforming in presence of hydrazine for hydrogen production
Published 2021“…Thermodynamic analysis of hydrogen production from propanol reforming reactions, by decomposition and steam reforming, in presence of hydrazine was evaluated as a function of temperature (300-900 K) at a constant pressure of 1 atm. …”
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A Multi-echelon Network Distribution Model For Emergency Resource Planning
Published 2014“…The model is tested in a network for numerical analysis. The result shows that multiple SPs in the proposed network distribution structure helps to overcome the possible resource disruption that occurs with single sourcing in the centralized structure, resulting decrease of the demand shortage. …”
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412
Ultra-low thermal conductivity in scheelite and A-deficient scheelite ceramics
Published 2021“…BaMoO ceramic has shown a decrease in thermal conductivity from 0.8 W m K to 0.65 W m K from 400 K to 650 K. …”
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413
Optimizing cancer therapy: a review of the multifaceted effects of metronomic chemotherapy
Published 2024“…Metronomic chemotherapy (MCT), characterized by the continuous administration of chemotherapeutics at a lower dose without prolonged drug-free periods, has garnered significant attention over the last 2 decades. …”
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Physical activity in pregnancy prevents gestational diabetes: A meta-analysis
Published 2020“…Data obtained were synthesised using a bias-adjusted model of meta-analysis. ResultsA total of 1467 adult women in 11 eligible trials were included. …”
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Bio-Inspired Fabrication of Ultrafiltration Membranes Incorporating Polydopamine Functionalized Graphene Oxide Nanoparticles
Published 2021“…Thus, the flux increased with the embedding of rGO-PDA without affecting the rejection properties, while it decreased with the embedding of pristine GO. The highest pure water permeability (PWP) was obtained with PSF/rGO PDA-0.1 to be approximately twice that of the pristine PSF and PSF/GO-0.1. …”
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Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co...
Published 2024“…Non-communicable diseases contributed 1·73 billion (95% UI 1·54–1·94) DALYs in 2021, with a decrease in age-standardised DALY rates since 2010 of 6·4% (95% UI 3·5–9·5). …”
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Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co...
Published 2024“…Non-communicable diseases contributed 1·73 billion (95% UI 1·54–1·94) DALYs in 2021, with a decrease in age-standardised DALY rates since 2010 of 6·4% (95% UI 3·5–9·5). …”
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Albumin administration in patients with decompensated liver cirrhosis: A meta-analytic update
Published 2021“…Heterogeneity was mild across all studies (I223.3%). Studies reporting long-term albumin (LTA) administration were found to have a significant decrease in mortality (RR 0.57, 95% CI 0.44-0.73). …”
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A LONG-TERM 10G-HYPERGRAVITY EXPOSURE PROMOTES CELL-CELL CONTACTS AND REDUCES ADHESIVENESS TO A SUBSTRATE, MIGRATION, AND INVASIVENESS OF MCF-7HUMAN BREAST CANCER CELLS.
Published 2022“…G-force is a fundamental force controlling human cells. Cancer is one of the 4 major health challenges in the Space missions. …”
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A disease-modifying treatment for Alzheimer's disease: Focus on the trans-sulfuration pathway
Published 2019“…There is a decrease in aconitase 1 (ACO1) in AD. ACO1 is an iron-sulfur enzyme in the citric acid cycle that upon loss of an iron-sulfur cluster converts to iron regulatory protein 1 (IRP1). …”
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