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MOLECULAR FEATURES OF TRIPLE NEGATIVE BREAST CANCER STEM CELLS: A GENE EXPRESSION PROFILING ANALYSIS OF MDA-MB-231 CELLS
Published 2021“…Nonetheless, CYP3A4, and CYP2D6 were lower in CSCs by 75%, 23%, 43%, 23.8%, and 17%, respectively. …”
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Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov...
Published 2023“…AimIn this study, we aimed to conduct a comparative assessment of antibody responses between vaccinated naïve (VN) and unvaccinated naturally infected individuals (NI) over 10 Months. …”
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Follow up and comparative assessment of IgG, IgA, and neutralizing antibody responses to SARS-CoV-2 between mRNA-vaccinated naïve and unvaccinated naturally infected individuals ov...
Published 2023“…AimIn this study, we aimed to conduct a comparative assessment of antibody responses between vaccinated naïve (VN) and unvaccinated naturally infected individuals (NI) over 10 Months. …”
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Association between Serum Vitamin D Status and Circadian Syndrome: A Cross-Sectional Study
Published 2024“…Results: Our results indicated that low vitamin D levels exhibited meaningful associations with CircS, with vitamin D deficiency and inadequacy demonstrating 2.21-fold (95% CI 1.78-2.74, p < 0.001) and 1.33-fold (95% CI 1.14-1.54, p < 0.001) increases in CircS odds, respectively. …”
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Evidence of two mechanisms involved in Bacillus thuringiensis israelensis decreased toxicity against mosquito larvae: Genome dynamic and toxins stability
Published 2015“…This bacterium is characterized by a dynamic genome able to win or lose genetic materials which leads to a decrease in its effectiveness. …”
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The Impact of COVID-19 on Physical (In)Activity Behavior in 10 Arab Countries
Published 2022“…Insufficient physical activity is considered a strong risk factor associated with non-communicable diseases. …”
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A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation...
Published 2019“…The molecular interaction study also revealed that the co-crystallized AKT1 inhibitor N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo [4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide (12j) exhibited a better interaction with native AKT1 compared with the E17K mutant AKT1 protein, whereas, Akti-1/2 exhibited the opposite effects, i.e., a better interaction with the E17K mutant AKT1 than the native AKT1. …”
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Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2.
Published 2018“…In the case of D2HGDH protein, the mutations I147S and V444A that are positioned in the beta sheet region exhibited higher Root Mean Square Deviation (RMSD), decrease in compactness and number of intramolecular hydrogen bonds compared to the mutations N439D and D375Y that are positioned in the turn and loop region, respectively. …”
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A LONG-TERM 10G-HYPERGRAVITY EXPOSURE PROMOTES CELL-CELL CONTACTS AND REDUCES ADHESIVENESS TO A SUBSTRATE, MIGRATION, AND INVASIVENESS OF MCF-7HUMAN BREAST CANCER CELLS.
Published 2022“…Proliferation, cell-cell interaction and formation of 3D structures, migration, and invasiveness of cells exposed to 10 g were compared to parental cells cultured at 1 g condition. 10 g exposed cells showed a higher propensity for cell-cell contact inhibitions and lower for 3-dimensional growth in dense culture. …”
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Adaptive thermal comfort in the different buildings of Darjeeling Hills in eastern India – Effect of difference in elevation
Published 2018“…Whereas, the mean comfort temperature decreased with the elevation of the location and this difference was also statistically significant, t = −92.34 (df = 2607, p < 0.001). …”
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Tailoring the deposition of MoSe2 on TiO2 nanorods arrays via radiofrequency magnetron sputtering for enhanced photoelectrochemical water splitting
Published 2023“…Compared to pure TiO2 NRs, the heterojunction nanostructured assembly displayed excellent spectral and photoelectrochemical properties, including more surface oxygen vacancies, enhanced visible-light absorption, higher photocurrent response, and decreased charge transfer resistance. In particular, the sample synthesized by sputtering of MoSe2 for 90 s, i.e., MoSe2@TiO2-90 s, depicted the highest current density (1.86 mA cm−2 at 0.5 V vs. …”
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Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2.
Published 2018“…GALK enzyme catalyzes the adenosine triphosphate (ATP)-dependent phosphorylation of α-d-galactose to galactose-1-phosphate. We searched 4 different literature databases (Google Scholar, PubMed, PubMed Central, and Science Direct) and 3 gene-variant databases (Online Mendelian Inheritance in Man, Human Gene Mutation Database, and UniProt) to collect all the reported missense mutations associated with GALK deficiency. …”
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Abnormal brain structure and behavior in MyD88-deficient mice.
Published 2020“…Because the adaptor protein myeloid differentiation primary response protein 88 (MyD88) is essential for downstream signaling of most TLRs and IL-1R, we systematically investigated the effect of MyD88 deficiency on murine brain structure during development and on behavior. …”
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25-Hydroxyvitamin D serum levels inversely correlate to disease severity and serum C-reactive protein levels in patients with hidradenitis suppurativa
Published 2021“…Subsequently, Guillet et al.5 described an association between vitamin D deficiency and HS severity, also reporting a significant decrease of the inflammatory nodules in patients supplemented with vitamin D. …”
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