At 20-30 hpf, zebrafish heart is morphologically a tube-like structure with a AV canal (AV) separating the atrium (A) and ventricle (V). by Juhyun Lee (449913)

“…Contoured velocity profiles confirm the observed result (g–i). Red bars in (a–c) represent the time points at which the corresponding velocity profiles were reconstructed. …”

Colony-stimulating factor 1 receptor (CSF1R) inhibition depleted microglia and increased the density of neurons in the ischemic cortical region after stroke. by Eric Yuhsiang Wang (17131666)

Glycolysis is crucial for phagosome maturation upon infection in macrophages. by Saray Gutiérrez (11473528)

CDA deficiency leads to excess dCTP, inhibiting PARP-1 activity and leading to UFB formation. by Simon Gemble (168663)

“…Statistical significance was calculated with Student’s <i>t</i>-test. (G) (1) CDA deficiency leads to intracellular dCTP accumulation, decreasing basal PARP-1 activity. (2) The decrease in basal PARP-1 activity leads to an increase in unreplicated DNA sequences (preferentially at centromeres and CFS sites). (3) During late G2/early mitosis, some of this unreplicated DNA is probably processed by MUS81-EME1 and ERCC1 nucleases as previously suggested [<a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005384#pgen.1005384.ref036" target="_blank">36</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1005384#pgen.1005384.ref012" target="_blank">12</a>], leading to DNA synthesis during metaphase (EdU foci) and preventing supernumerary UFB formation. (4) Some of the excess unreplicated DNA sequences are not processed by the nucleases, leading to supernumerary UFB formation.…”

CTGF immunoreactivity is decreased and CTGF mRNA is down-regulated in co-cultures of GBM cells with neurons. by Luciana F. Romão (278706)

“…The arrowhead shows a CTGF stained E18 neuron (D). Notice that CTGF staining decreased in co-cultures (comparing A with D and G). …”

Kinetics of bee venom specific antibodies. by Andreas Hartmann (241073)

Decreased PPAR-γ signaling increases eNOS uncoupling in ovine pulmonary arterial endothelial cells. by Shruti Sharma (308114)

“…PPAR-γ siRNA transfection significantly increased eNOS-derived superoxide levels (D) and decreased NO levels (E) but only under shear-stimulated conditions. …”

Fatal autoimmune disorder in mice with T_reg cell–specific disruption of <i>miR-142</i>. by Wei-Le Wang (133402)

Ab Initio Study of the Substituent Effects on the Relative Stability of the <i>E</i> and <i>Z</i> Conformers of Phenyl Esters. Stereoelectronic Effects on the Reactivity of the Car... by Helmi Neuvonen (2643793)

“…ED/EW substituents adjust the availability of the π*_C__O antibonding orbital to interact with the lone pair orbital of the attacking nucleophile and therefore affect the reactivity:  EW substituents increase and ED substituents decrease it. Excellent correlations were observed between the rate coefficients of nucleophilic acyl substitutions and π*_C__O occupancies of the ester series <b>4 </b>and <b>5</b>.…”

Maternal exposure to U-46619 decreases fetal body weight at E19 compared to sham pups. by Camille M. Fung (844334)

“…<p>Pregnant mice were exposed to a TXA₂- analog (U-46619) or vehicle via micro-osmotic pump infusion from E12.5 until birth (term ~20 days). …”

Designed small-molecule inhibitors show decreased specificity towards human HDACs and induce apoptosis in schistosomes. by Martin Marek (463593)

Simvastatin and Benznidazole-Mediated Prevention of <i>Trypanosoma cruzi</i>-Induced Endothelial Activation: Role of 15-epi-lipoxin A4 in the Action of Simvastatin by Carolina Campos-Estrada (403914)

“…Simvastatin has anti-inflammatory actions, including improvement of endothelial function, by inducing a novel pro-resolving lipid, the 5-lypoxygenase derivative 15-epi-lipoxin A4 (15-epi-LXA4), which belongs to aspirin-triggered lipoxins. …”

Maternal <i>tudor[1]</i> mutation effect on life span, egg laying and response to RH5849 and mifepristone. by Gary N. Landis (11475733)

Functional diversity (A), succession rate (B), food quality (C), and system residence times (D). by Alice Boit (528321)

“…<i>SRT_C</i> and <i>SRT_P</i> were maximal during the CWP due to the dominance of larger crustaceans with slower metabolism and in autumn-winter due to decreasing temperature and on average lower metabolic activity (Fig. 5D).…”

PTX frequency (per year). by Yukiko Namba (6829589)

Residual enzyme activity after <i>in vivo</i> inhibition. by Kiranpreet Kaur (245053)

Macrophage depend on glycolysis for the clearance of intracellular bacteria. by Saray Gutiérrez (11473528)

Total, free, and bound thrombin of 10,000 simulations of blood clotting over collagen/ TF under venous flow rate. by Jason Chen (15937)

DataSheet_1_Extracellular vesicles secreted by 3D tumor organoids are enriched for immune regulatory signaling biomolecules compared to conventional 2D glioblastoma cell systems.xl... by Martina Schuster (18440214)

“…Moreover, we identified four miRNAs (miR-323a-3p, miR-382-5p, miR-370-3p, miR-134-5p) located within the DLK1-DIO3 domain, a cancer-associated genomic region, suggesting a possible importance of this region in glioblastoma progression. …”

Advancing the science of NOWS research. by Sarah E. Maylott (14560785)

“…Approximately 50% of these newborns will develop Neonatal Opioid Withdrawal Syndrome (NOWS) within 5 days of birth. It is not known which infants will develop NOWS, therefore, the current hospital standard-of-care dictates a 96-hour observational hold. …”