Showing 15,061 - 15,080 results of 107,690 for search '(( i de decrease ) OR ( 5 ((point decrease) OR (((mean decrease) OR (a decrease)))) ))', query time: 1.19s Refine Results
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    Representative activity cliffs for the proprietary hERG blocker series 1 (see text) comprised of R1 (corresponding to BP) and R2/R3 (corresponding to BC). by Hongbin Wan (1904146)

    Published 2020
    “…<p>The large decrease in percent inhibition @ 1 μM for structure 3 compared with structures 1 and 2 is putatively attributable to the greater re-solvation cost of Cl versus F, together with increased polarity and solubility/de-solvation cost of the ortho- versus meta-pyridyl nitrogen, (consistent with the lack of hERG-contributed H-bond replacements for the water solvating this moiety in the unbound state).…”
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    <i>NHD13/Rag1</i>KO mice have decreased survival and an increased incidence of leukemia. by Sheryl M. Gough (323307)

    Published 2013
    “…<p>(A) Survival is dramatically reduced in the <i>NHD13</i> mice and further decreased in the <i>NHD13/Rag1</i>KO cohort (Mantel Cox test p = 0.01); median lifespan of the <i>NHD13/Rag1</i>KO mice is two months less than the NHD13 cohort. …”
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    Selected PK parameters and clinical signs in ferrets challenged with influenza A viruses (Study 1). by Micaela B. Reddy (384270)

    Published 2015
    “…The number of ferrets per total number of animals in that group that had more than a 5% loss of initial weight on day 5 p.i. is shown in parenthesis.…”
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