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Aquaporin 2 Mutations in <i>Trypanosoma brucei gambiense</i> Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol
Published 2013“…Here we describe two different kinds of <i>TbAQP2</i> mutations found in <i>T. b. gambiense</i> field isolates: simple loss of <i>TbAQP2</i>, or loss of wild-type <i>TbAQP2</i> allele combined with the formation of a novel type of <i>TbAQP2/3</i> chimera. The identified mutant <i>T. b. gambiense</i> are 40- to 50-fold less sensitive to pentamidine and 3- to 5-times less sensitive to melarsoprol than the reference isolates. …”
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143
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The Hh signaling pathway effectors are decreased in E14.5 <i>Fuz<sup>−/−</sup></i> mouse embryos.
Published 2013“…<p><b>A</b>) Immunofluorescence of Patched1 in sagittal sections of E14.5 <i>Fuz<sup>+/−</sup></i> heterozygous embryos. …”
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145
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GREAT GO analysis of WDR5 and MYCN overlapped ChIP-seq peaks with >2.5-fold decrease of WDR5 signal intensity after the silencing of <i>WDR5</i>.
Published 2024“…<p>GREAT GO analysis of WDR5 and MYCN overlapped ChIP-seq peaks with >2.5-fold decrease of WDR5 signal intensity after the silencing of <i>WDR5</i>.…”
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Downregulation of DOM decreases the abundance of PER and TIM.
Published 2019“…Downregulation of DOM decreased PER levels at CT1-5 and CT17-21. (Scale bar: 50 um.) …”
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Increased oxidative stress, viral load and decreased survivability of N2a following RIG-I ablation.
Published 2011“…The mean fluorescence intensities obtained from each group are depicted in the figure. (1-Unstained, 2-Mock-infected; 3-JEV-infected, 4-JEV+Sc-MO, 5-JEV+rMO) (A). …”
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GFP activity is decreased in DES.
Published 2017“…<p><b>(a)</b> Scatterplots show that CGC number determined on histological sections (AB—PAS coloration), and GFP<sup>+</sup> (Muc5b) and Muc5ac<sup>+</sup> CGC number determined by immunofluorescence staining (anti-GFP and anti-Muc5ac antibody) decreased (n = 10 mice, 1 section per mouse, one symbol/mouse) after 10 days of BAK application (filled-in symbols) in one eye (PBS in the other, white-filled symbols) followed by 4 days without any treatment. …”
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