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Api5 depletion induces a decrease in E2F1-target gene mRNA levels without affecting E2F1 expression.
Published 2013“…<p><b>A.</b> Api5 and E2F1 reciprocal regulation. After depletion of Api5 and E2F1 with specific siRNAs, H1299 cells were made quiescent by serum starvation for 48 h (0% FBS) and then allowed to progress through the cell cycle over 10 hours by FBS addition (10 h refeeding). …”
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Fold change in humoral and cellular response magnitudes from RV305 week 2 to week 26.
Published 2023Subjects: -
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Decreased <i>Pax2</i> expression in <i>p53<sup>−/−</sup></i> embryonic kidneys.
Published 2012“…<b>B</b>) In situ hybridization. Decreased expression of <i>Pax2</i> mRNA at E12.5. …”
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OCA alone markedly decreases and combined with Gemcitabine or Cisplatin abrogates growth of iCCA xenografts.
Published 2019“…Photographs (1x magnification) are representative of tumors formed after 5 weeks of treatment. b) Hematoxylin and eosin (H&E) stain on tumor samples from control mice (CTRL) and mice treated with OCA, Gemcitabine (GEM), Cisplatinum (CIS), and the indicated combinations. …”
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Wnt5a expressing tumors demonstrate a decrease in markers of the basal tumor subtype.
Published 2014“…Values are means +/− standard error (n = 6 MMTV-Wnt1, 3 fields per tumor; n = 5 MMTV-Wnt1;MMTV-Wnt5a, 3 fields per tumor). MMTV-Wnt1;MMTV-Wnt5a tumors demonstrated a significant decrease in K6-expressing cells as measured by T-test (* = p<0.05).…”
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Decreased diaphragm muscle lateral bifurcations in GAD67-deficient (−/−) E15.5 mice.
Published 2013“…<p>Axonal branches (green) and acetylcholine receptor clusters (red) in the diaphragm muscle in E15.5 wild type (<b>A</b>, <i>+/+</i>) and GAD67-deficient (<b>B</b>, <i>−/−</i>) are shown. …”
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