OCA alone markedly decreases and combined with Gemcitabine or Cisplatin abrogates growth of iCCA xenografts. by S. Di Matteo (6260417)

“…Photographs (1x magnification) are representative of tumors formed after 5 weeks of treatment. b) Hematoxylin and eosin (H&E) stain on tumor samples from control mice (CTRL) and mice treated with OCA, Gemcitabine (GEM), Cisplatinum (CIS), and the indicated combinations. …”

SMC-specific knockout of Klf5 (smcKlf5^−/−) exacerbates the progression of Ang II–induced AAA by facilitating ROS formation. by Dong Ma (584680)

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Mfsd2a KO mice have decreased liver TG with normal liver metabolism. by Justin H. Berger (297156)

<i>RTTN</i>-mutated organoids exhibit decreased proliferation and increased cell death at early stages. by Justine Guguin (9088672)

Klf5 deficiency in mouse VSMCs leads to mitochondrial fission. by Dong Ma (584680)

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Klf5 deficiency leads to mitochondrial dyfunction in VSMCs. by Dong Ma (584680)

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The correlation of the mitochondrial dynamics–related genes with Klf5 in mouse VSMCs. by Dong Ma (584680)

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Promoter reporter studies for reported <i>NR5A1</i> mutations by Jana Malikova (615672)

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NCM treatment decreases hepatic CoQ₁₀, but increases total cholesterol and cholesterol ester levels, which is associated with significant decreases in the expressions of... by Ryan J. Mailloux (50825)

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Inhibition of ALK4/5/7 decreases Sertoli cell proliferation in E12.5 fetal testes. by Denise C. Miles (218867)

Wnt5a expressing tumors demonstrate a decrease in markers of the basal tumor subtype. by Stephanie L. Easter (662168)

“…Values are means +/− standard error (n = 6 MMTV-Wnt1, 3 fields per tumor; n = 5 MMTV-Wnt1;MMTV-Wnt5a, 3 fields per tumor). MMTV-Wnt1;MMTV-Wnt5a tumors demonstrated a significant decrease in K6-expressing cells as measured by T-test (* = p<0.05).…”

Decreased <i>Resf1</i> in cell lines paradoxically decreases metastatic capacity. by Megan R. Majocha (18529925)

Decreased NK1.1^pos iNKT cell numbers in the peripheral organs of T cell-specific <i>Gfi1</i>-deficient mice. by Toshiaki Yasuoka (2827457)

Decreased diaphragm muscle lateral bifurcations in GAD67-deficient (−/−) E15.5 mice. by Matthew J. Fogarty (283288)

“…<p>Axonal branches (green) and acetylcholine receptor clusters (red) in the diaphragm muscle in E15.5 wild type (<b>A</b>, <i>+/+</i>) and GAD67-deficient (<b>B</b>, <i>−/−</i>) are shown. …”

Whsc1 deficiency decreases the expression of bone tissue-related genes in E18.5 occipital bones, sternum and sternebrae. by Yu Fei Lee (626002)

Increased cell death and decreased proliferation of neural progenitors in the E18.5 <i>Nestin-Dicer cko</i> hippocampus. by Qingsong Li (342843)

“…<p>(A) A coronal section with Nissl staining of the E18.5 wild type hippocampus. …”

Brain and liver GCase activity are significantly decreased in heterozygous <i>GBA1</i> D409V KI mice, with varying differences in glucosphingolipid lipids in brain and liver. by Nicole K. Polinski (10947787)

“…<p>(A-B) GCase, (C-D) gluocosylceramide (GlcCer), and (E-F) glucosylsphingosine (GlcSph) levels measured in whole brain homogenate and liver homogenate of C57Bl/6 wild type (WT) and <i>GBA1</i> D409V KI heterozygous (HET) mice at 5 months of age (n = 10/age). …”

GCase activity is significantly decreased in the brain and liver of the homozygous <i>GBA1</i> D409V KI mouse model at 4, 8, and 12 months of age. by Nicole K. Polinski (10947787)

“…In whole brain homogenate (A,C) and liver homogenate (B,D), GCase activity is significantly decreased in the <i>GBA1</i> D409V KI homozygous (HOM) mice as compared to C57Bl/6 wild type (WT) mice (n = 7/group). …”

Phlorizin decreased renal GTTR uptake, and increased serum drug levels <i>in vivo</i>. by Meiyan Jiang (438439)

Overexpression of ATX delays retinal vascularization and decreases vessel branching. by Hiroshi Yukiura (741223)