Showing 301 - 320 results of 101,016 for search '(( i ex decrease ) OR ( 5 ((((step decrease) OR (nn decrease))) OR (a decrease)) ))', query time: 1.35s Refine Results
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    Target specificity, <i>in vivo</i> pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma by Peter Y. Yu (4281448)

    Published 2017
    “…The purpose of this work was to develop and test a novel putative STAT3 inhibitor, LY5.</p><p>Methods and findings</p><p>An <i>in silico</i> fragment-based drug design strategy was used to create LY5, a small molecule inhibitor that blocks the STAT3 SH2 domain phosphotyrosine binding site, inhibiting homodimerization. …”
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    Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses by Jing Wang (6206297)

    Published 2025
    “…However, how global land use changes impact soil N supply and potential N loss remains elusive. By compiling a global data set of 1,782 paired observations from 185 publications, we show that land use conversion from natural to managed ecosystems significantly reduced NNM by 7.5% (−11.5, −2.8%) and increased NN by 150% (86, 194%), indicating decreasing N availability while increasing potential N loss through denitrification and nitrate leaching. …”
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    Decrease of SMAD3 protein, but not SMAD2 in DBA iPSCs. by Jingping Ge (636557)

    Published 2015
    “…The nuclear p-SMAD2 decreased in <i>RPL5</i> mutant and corrected lines. …”
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    Table_2_Dimethylethanolamine Decreases Epileptiform Activity in Acute Human Hippocampal Slices in vitro.docx by Larissa Kraus (7353074)

    Published 2019
    “…We further tested whether DMEA can exert antiepileptic effects in human brain tissue ex vivo. We analyzed the effect of DMEA on epileptiform activity in the CA1 region of the resected hippocampus of TLE patients in vitro by recording extracellular field potentials in the pyramidal cell layer. …”
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    Image_3_Dimethylethanolamine Decreases Epileptiform Activity in Acute Human Hippocampal Slices in vitro.TIF by Larissa Kraus (7353074)

    Published 2019
    “…We further tested whether DMEA can exert antiepileptic effects in human brain tissue ex vivo. We analyzed the effect of DMEA on epileptiform activity in the CA1 region of the resected hippocampus of TLE patients in vitro by recording extracellular field potentials in the pyramidal cell layer. …”