Inactivation of Topo IV leads to a specific inability to replicate the terminus region of the chromosome. by Parisa D. Mokhtari (22209097)

“…<p>Replication profiles of growing wild-type, <i><i>gyrB</i></i>^ts, and <i><i>parE</i></i>^ts cells are plotted at 0, 1.5, and 3 hrs after temperature shift from 30°C to 43°C. …”

A high vaccine uptake (> 90% or higher among the eligible population) is crucial to prevent a wave when lifting restrictions after completing vaccination campaigns. by Simon Bauer (11378195)

Table 5_Therapeutic potential of five frequently prescribed herbs in obesity-associated Hashimoto’s thyroiditis: insights from efferocytosis regulation.xlsx by Jiahao Zhou (11385383)

“…Moreover, TCM offers significant benefits in regulating lipid metabolism and decreasing systemic inflammation.</p>Methods<p>Targets of five high-frequency herbs (Hedysarum multijugum Maxim, Radix Bupleuri, Prunella vulgaris, Fritillaria thunbergii Bulbus, and Angelicae sinensis Radix) were obtained from the TCMSP and Swiss Target Prediction databases. …”

Percent decrease of the marker pigment concentrations (mean ± standard deviation of triplicate microcosms, and the probability) treated with 1.6 mg L⁻¹ H₂O<su... by Varunpreet Randhawa (302690)

Inhibition of Neuroblastoma Tumor Growth by Ketogenic Diet and/or Calorie Restriction in a CD1-Nu Mouse Model by Raphael Johannes Morscher (751235)

“…Neuroblastoma growth reduction correlated with decreased blood glucose concentrations and was characterized by a significant decrease in Ki-67 and phospho-histone H3 levels in the diet groups with low tumor growth. …”

Effect of H₂O₂ on cell membrane rupture in hypo-osmotic conditions. by Alexis Mougeolle (709121)

Changes after 45 minutes in the proportion of LTP, LTD or no plasticity responses observed in L5PyNs population induced by the HFS protocol in the presence of D1R agonist or antago... by Claire Nicole Jeanne Meunier (703124)

“…<p>(A and D) Percentages of L5PyNs displaying LTP, LTD or no plasticity in 129/Sv mice and 5-HT_1AR-KO mice in control conditions. …”

Table_5_Integrative Analysis of LGR5/6 Gene Variants, Gut Microbiota Composition and Osteoporosis Risk in Elderly Population.DOCX by Dong-sheng Di (11634688)

“…The rs10920362 CT/TT genotype associated with a decreased relative abundance of Actinobacteria (β = −1.32, P < 0.001), Bifidobacteriaceae (β = −1.70, P < 0.001), and Bifidobacterium (β = −1.70, P < 0.001) compared to the CC genotype.…”

BrdU assay in control siRNA (blue bars) and in PAX6 knockdown (red bars) limbal epithelial cells (LECs) without and after 1µM or 5µM RA incubation for 48 hours. by Shao-Lun Hsu (6856259)

“…Significant p values (<0.05) are highlighted. BrdU assay shows a significantly lower proliferation rate in the PAX6 siRNA knockdown group than in control siRNA group (p < 0.001). 5µM RA treatment significantly decreased proliferation rate in controls (p = 0.025). …”

Generation and Tg^cog protein expression profile of the <i>ColIITg^cog</i> mouse. by Louise H. W. Kung (693522)

Exceedance probability distribution function of species interactions and phase-space dependent on surface temperature. by Jie Li (15030)

Anomalous Non-Prussian Blue Structures and Magnetic Ordering of K₂Mn^II[Mn^II(CN)₆] and Rb₂Mn^II[Mn^II(CN)<... by Jae-Hyuk Her (1769134)

“…The magnetic ordering temperature, <i>T</i>_c, increases as K⁺ (41 K) > Rb⁺ (34.6 K) > Cs⁺ (21 K) for A₂Mn[Mn(CN)₆] in accord with the increasing deviation for linearity of the Mn−N−C linkages [148.8 (K⁺) > 153.3 (Rb⁺) > 180° (Cs⁺)], decreasing Mn(II)···Mn(II) separations [5.09 (K⁺) < 5.19 (Rb⁺) < 5.30 Å (Cs⁺)], and decreasing size of the cation (increasing electrostatic interactions). …”

Confirmation of miRNA level by RT-qPCR. by Qin-Min Ge (3838885)

“…<p>Relative expression of each miRNA was normalized to hsa-miR-423-5p level. miR-142-5p, miR-22-3p, miR-191-5p, miR-23a-3p and miR-4456 were significantly decreased in both the sepsis-induced AKI and sepsis-non AKI groups compared with the healthy controls. miR-4270, miR-4321 and miR-3165 were obviously increased in the sepsis-induced AKI, and miR-3165 also was obviously increased in sepsis-non AKI group compared with the healthy controls. …”

microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration - Fig 6 by Surjyadipta Bhattacharjee (3181674)

“…After vacuum evaporation of HFIP, aliquoted peptide was re-suspended with DMSO to 5 mM and diluted to 5 μM into the cell culture media; <b>(B)</b> cells were treated with a scrambled miRNA-34a sequence (miRNA-34a-<b>sc</b>; 30 nM;, control, <b>a-d</b>, middle row); or <b>(C)</b> with an LNA-stabilized miRNA-34a (30 nM; miRNA-34a stressed; <b>a-d</b>; bottom row); treatments were for 24 hr before incubation with 5 uM of Aβ42 (made up as in [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.ref033" target="_blank">33</a>]) for another 24 hr before assay; MG cells were subsequently stained using a murine amyloid beta MABN10 (red fluorescence λ_max~650 nm; anti-Aβ antibody, clone W0-2; Millipore, Bellerica MA), a TREM-2 antibody (M-227): sc-48765 (green fluorescence; λ_max~510 nm; Santa Cruz, Santa Cruz CA) or DAPI nuclear stain (blue fluorescence; λ_max~470 nm) as in <b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0150211#pone.0150211.g003" target="_blank">Fig 3</a>;</b> arrows indicate Aβ42 uptake into MG cells; note decreased presence of TREM2 in miRNA-34a treated MG cells (bottom row, panel B) and decrease in ingested Aβ42 peptide within C8B4 cells (<b>C</b>; bottom row, panel <b>d</b>). …”

Characterization of serum cytokines during systemic infection with an <i>fgr41Δ/Δ</i> mutant. by Andrew S. Wagner (11331477)

High Pressure Study of Ru₃(CO)₁₂ by X-ray Diffraction, Raman, and Infrared Spectroscopy by Carla Slebodnick (90300)

“…The single-crystal X-ray structure of Ru₃(CO)₁₂ is reported at 8 pressures ranging from 1 atm (0.0 GPa) to 8.14(5) GPa. Although intramolecular bonding parameters remain relatively constant, intramolecular and intermolecular nonbonding contact distances decrease by an average of 4% and 15%, respectively. …”

Conditional <i>Cdk5rap2</i> KO mouse and novel <i>mCdk5rap2</i> splice variants. by Nadine Kraemer (790327)

“…(D) Identification of a novel <i>mCdk5rap2</i> splice variant (<i>mCdk5rap2-V1</i>) through gel electrophoresis and sequencing of PCR products from exon 2 to exon 7 of WT and hom KO cDNA. …”

Analysis of the various EcFicTA complexes in solution. by Frédéric V. Stanger (585551)

Data_Sheet_1_Renal X-inactivation in female individuals with X-linked Alport syndrome primarily determined by age.PDF by Roman Günthner (8435811)

“…<p>X-linked Alport syndrome (AS) caused by hemizygous disease-causing variants in COL4A5 primarily affects males. Females with a heterozygous state show a diverse phenotypic spectrum ranging from microscopic hematuria to end-stage kidney disease (ESKD) and extrarenal manifestations. …”

Structural−Electronic Correlation in the First-Order Phase Transition of [FeH₂L^2-Me](ClO₄)₂ (H₂L^2-Me = Bis[((2-met... by Nicolas Bréfuel (2519947)

“…Variable-temperature magnetic susceptibility measurements show the occurrence of a steep spin crossover centered at 171.5 K with a hysteresis loop of ca. 5 K width ( =174 K and = 169 K, for increasing and decreasing temperatures, respectively). …”