Prolonged exposure to oxidized LDL particles decreases Cx36 levels in β-cells. by Jacques-Antoine Haefliger (134116)

Target specificity, <i>in vivo</i> pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma by Peter Y. Yu (4281448)

“…The purpose of this work was to develop and test a novel putative STAT3 inhibitor, LY5.</p><p>Methods and findings</p><p>An <i>in silico</i> fragment-based drug design strategy was used to create LY5, a small molecule inhibitor that blocks the STAT3 SH2 domain phosphotyrosine binding site, inhibiting homodimerization. …”

Global Land Use Change Impacts on Soil Nitrogen Availability and Environmental Losses by Jing Wang (6206297)

“…However, how global land use changes impact soil N supply and potential N loss remains elusive. By compiling a global data set of 1,782 paired observations from 185 publications, we show that land use conversion from natural to managed ecosystems significantly reduced NNM by 7.5% (−11.5, −2.8%) and increased NN by 150% (86, 194%), indicating decreasing N availability while increasing potential N loss through denitrification and nitrate leaching. …”

CsA reduces Flk1 protein expression and significantly decreases the percentages of Flk1+ cells. by Seung-Cheol Choi (686982)

(A) The temperature sensitive allele of <i>HEM1</i> leads to a significant decrease in the endogenous levels of Cia2 and Mms19. by Ifat Lev (469072)

Assessment of the protective efficacy of SinH-3 against the bacteremia of multiple ExPEC sequence types (STs). by Yikun Xing (9427893)

CD107a-, IFNγ- and MIP 1β-producing Vγ9Vδ2 T-cell subsets decrease in HIV+ patients. by Rita Casetti (608635)

Loss of <i>Otop1</i> decreases BAT maximal mitochondrial respiration in palmitate-rich environment. by Yu-Hsiang Tu (17118218)

Table_2_Dimethylethanolamine Decreases Epileptiform Activity in Acute Human Hippocampal Slices in vitro.docx by Larissa Kraus (7353074)

“…We further tested whether DMEA can exert antiepileptic effects in human brain tissue ex vivo. We analyzed the effect of DMEA on epileptiform activity in the CA1 region of the resected hippocampus of TLE patients in vitro by recording extracellular field potentials in the pyramidal cell layer. …”

Image_3_Dimethylethanolamine Decreases Epileptiform Activity in Acute Human Hippocampal Slices in vitro.TIF by Larissa Kraus (7353074)

“…We further tested whether DMEA can exert antiepileptic effects in human brain tissue ex vivo. We analyzed the effect of DMEA on epileptiform activity in the CA1 region of the resected hippocampus of TLE patients in vitro by recording extracellular field potentials in the pyramidal cell layer. …”

Image_2_Dimethylethanolamine Decreases Epileptiform Activity in Acute Human Hippocampal Slices in vitro.TIF by Larissa Kraus (7353074)

“…We further tested whether DMEA can exert antiepileptic effects in human brain tissue ex vivo. We analyzed the effect of DMEA on epileptiform activity in the CA1 region of the resected hippocampus of TLE patients in vitro by recording extracellular field potentials in the pyramidal cell layer. …”

The effect of background light on WT and TrUx;GapOx rods: Response–intensity and Weber-Fechner curves. by Ala Morshedian (4165957)

Foxo1 decreases <i>SCN5a</i> promoter activity. by Weike Mao (181121)

Nicotine decreased Wnt5a expressions in SK-BR-3 cells. by Masanori A. Murayama (5774585)

A decrease in circulating CXCR5+CD4+ Tfh cells is associated with HCC progression, and CXCR5+CD4+ Tfh cells are decreased in tumor regions. by Yiqiong Jia (692871)

“…<p>(A) The prevalence of CXCR5+CD4+ Tfh cells decreases with progressive stages in HCC. …”

Increased expression of Fz5 receptor matched with a decrease in NeuN immunoreactivity at 16w. by Carlos González-Fernández (2794207)

Mice lacking the type 4 melanocortin receptor have a normal muscle fiber type distribution with a decreased resting heart rate. by Theodore P. Braun (228920)

“…<p>Skeletal and cardiac muscle was examined in in 11-week old male WT (n = 5) and MC4RKO (n = 6) mice. (<b>A</b>) Resting heart rate was decreased in MC4RKO mice. …”

RGS5 deletion resulted in decreased peripheral insulin sensitivity and suppressed the Akt/GSK3β signaling pathway in mice fed an HF for 24 weeks. by Wei Deng (17330)

Cerebral edema and clinical signs of CM are decreased in α_D ^-/- mice infected with <i>P</i>. <i>berghei</i> ANKA. by Isaclaudia G. de Azevedo-Quintanilha (8173734)

<i>Y. pseudotuberculosis</i> lacking a functional IscR display decreased transcription of a number of pYV encoded genes. by Halie K. Miller (375675)

“…<p>Middle and inner rings: heatmap <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1004194#ppat.1004194-Krzywinski1" target="_blank">[83]</a> representations of log₂-ratios (log₂(RPKM_mutant/RPKM_wt) for each gene on the pYV plasmid for both the Δ<i>iscR</i> (middle ring) and apo-IscR (inner ring) mutants relative to wild type. …”