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The rate of lariat formation is decreased two-fold by isoginkgetin treatment.
Published 2014“…<p>(<b>A</b>) Genome-wide expression of 5′ splice sites, 3′ splice sites, and introns are increased relative to exons upon treatment of HeLa cells with isoginkgetin (30 µM, 18 hours), based on total RNA-Seq (dUTP method <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0089673#pone.0089673-Parkhomchuk1" target="_blank">[18]</a>, Illumina). The height of each bar indicates the fold change, from vehicle- to isoginkgetin-treated cells, in the mean fraction of reads aligning to each genic feature (<i>p</i><0.02 from two-tailed <i>t</i>-tests for all ratios). …”
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<i>Kdm6a</i> conditional KO mice have decreased repopulating potential in serial competitive transplantation assays.
Published 2021“…Whole BM cells were harvested from all cohorts of young <i>Kdm6a</i> conditional KO mice (CD45.2) and mixed with WT competitor marrow (CD45.1 x CD45.2) in a 1:1 ratio, which was then transplanted into lethally-irradiated primary recipient mice (CD45.1). …”
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Resveratrol decreases PKM2 expression.
Published 2013“…Relative quantification analysis was done using SDS 1.1 RQ software. Western blot showing decreased PKM2 protein in all the cell lines studied on treatment with 50 µM resveratrol (D). …”
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GSK343 decreased tumor stemness.
Published 2021“…Treatment with GSK343 significantly decreased tumorsphere formation by both the COA3 (A) and COA6 (B) cells, representing a decrease in stem cell-like phenotype. …”
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Decreased ISCs and increased goblet cells after intestinal specific loss of MLL1.
Published 2021“…(C) Decrease in ISC markers, OLFM4 and SOX9 in <i>Mll1</i><sup><i>FC/FC; Vil-Cre-ERT2/+</i></sup> intestinal sections. …”
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hESCs-Exo decreased cancer cell proliferation and increased cancer cell death.
Published 2017Subjects: