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point decrease » point increase (Expand Search)
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RelA–TA2 docks itself onto a series of interlinked hydrophobic grooves of TAZ1 through a number of hydrophobic residues, which serve as anchor points.
Published 2013“…<p>Disruption of any of the anchor points leads to the destabilization of the whole binding architecture of the complex. ∼2,800 Å<sup>2</sup> of RelA–TA2 surface area are buried upon formation of RelA–TA2:TAZ1 complex. …”
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Netrin-1 overexpression increases HCV RNA and specific infectivity of HCV virions in vitro whereas Netrin-1 depletion decreases HCV RNA and specific infectivity in vitro.
Published 2016“…Netrin-1 depletion impedes HCV. Huh7.5 cells were transfected with siRNAs, infected at a MOI of 0.1 24 h after seeding, and trypsinized at day five post-infection before a second siRNA transfection. …”
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653
Crystal structures of Triosephosphate Isomerases from <i>Taenia solium</i> and <i>Schistosoma mansoni</i> provide insights for vaccine rationale and drug design against helminth pa...
Published 2020“…Surprisingly, the epitopes corresponding to the SXD/E inserts are not the ones with the greatest immunological potential. SmTPI, but not TsTPI, habors a sole solvent exposed cysteine (SmTPI-S230) and alterations in this residue decrease catalysis. …”
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Validation of a New Scoring Scale for Behavioral Assessment of L‑Dopa-Induced Dyskinesia in the Rat: A New Tool for Early Decision-Making in Drug Development
Published 2017“…The rating scale was sensitive enough to highlight a dose-dependent amantadine-mediated decrease (about 2.2-fold) in LID score. …”
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5-HT inhibits <i>P</i>. <i>berghei</i> infection in mosquitoes.
Published 2024“…Data were pooled from two independent experiments and horizontal lines represented the medians. (K) Fold changes of male gametogenesis associated genes in the midguts of control (<i>n</i> = 8) and 1 μM 5-HT treated (<i>n</i> = 8) mosquitoes 15 min post-infection. …”
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