Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5‑ASA–PABA–MAC and 5‑ASA–PABA–Diamine for the T... by Jiaxing Zhao (3965057)

“…Specifically, compound <b>20g</b> displayed a 3.67-fold decrease of plasma AUC_{(tofacitinib, 0–∞)} and a 9.61-fold increase of colonic AUC_{(tofacitinib, 0–12h)}, compared with tofacitinib at a molar equivalent oral dose. …”

Three Ca_V3.3 variants left-shift the window current, while the A398V completely abolishes the window current. by Yousra El Ghaleb (22075892)

Subjects:

S C-terminal mutations that decrease ezrin interaction enhance transduction by pseudotyped particles in Vero E6 cells. by Jean Kaoru Millet (117227)

Transcriptomic and metabolomic analyses of liver of <i>Fmo5</i>^<i>-/-</i> and WT mice. by Ian R. Phillips (5074121)

“…<p>(A) Volcano plot representation of differentially expressed genes (log₂-fold change) of <i>Fmo5</i>^<i>-/-</i> vs WT mice. …”

Metabolites which were (A) reversibly decreased and (B) reversibly increased with smoking. by Charmion I. Cruickshank-Quinn (595143)

“…TG = triglyceride, CDP = cytidine-diphosphate, DG = diglyceride, PC = phosphatidylcholine, PS = phosphatidylserine, TG = triglyceride, PA = phosphatidic acid. Fold change ≥1.5; <i>p</i>-value≤0.05, x-axis = Log2 normalized abundance scale; Error bars represent 95% confidence; Significance values *≤0.05, **≤0.01, ***≤0.001.…”

Infection decreases short chain phospholipids in the intestines of <i>V</i>. <i>cholerae</i>-infected flies. by Audrey S. Vanhove (4090594)

Presentation_1_Eosinophils Decrease Pulmonary Metastatic Mammary Tumor Growth.pptx by Rachel A. Cederberg (12827564)

“…We found that IL5Tg mice exhibit reduced pulmonary metastatic colonization and decreased metastatic tumor burden compared to wild-type (WT) mice or eosinophil-deficient mice. …”

Rhox5 decreases UNC5C expression. by Mayumi Sugimoto (151133)

Metformin decreases ATP levels in medium containing low glucose (2.5 mM). by Yongxian Zhuang (634693)

Knockdown of factors in the 5′SS recognition complex U1 globally decreases intronic miRNA levels. by Maja M. Janas (200408)

JHMV N1347A has decreased replication in the olfactory bulbs of mice. by Catherine M. Kerr (21492574)

Inhibition of PKC or Rho protein kinase decreases Ad5 wild type replication <i>in vitro</i>. by Alice Liu (4814415)

Suppression does not depend on a growth rate decrease. by Laurent Jannière (28755)

GluN2A(D731N) decreases channel open probability. by Kai Gao (120150)

“…The receptors were activated by EC₅₀ concentrations of glutamate with saturating concentration (100 μM) of glycine at holding potential of -40 mV. The di-heteromeric mutant (2A-D731N) and tri-heteromeric receptors with two-copies of the mutant subunit (D731N/D731N) showed a prolonged inhibition rate, reflecting a decreased channel open probability. …”

Scotopic and photopic light responses are decreased in WT and miR-150^-/- mice fed with HFD. by Liheng Shi (144105)

IκBαM.1-Infected Mice Have Decreased Latency in Lung B Cells 16 dpi after Intranasal Infection by Laurie T Krug (68237)

Loss of <i>SLC4A11</i> expression in hCEnC leads to decreased cell barrier function. by Doug D. Chung (3611387)

<i>dnak14</i> mutant harbors a transposon insertion in the <i>dnaK</i> coding region and specifies a truncated DnaK protein. by Carissa Chan (18310140)

Loss of PAI-1-Vn interaction decreases proinflammatory cytokine and chemokine production after LPS challenge. by Kamlesh K. Gupta (709392)

SDF-1α decreased apoptosis in neonate cardiomyocytes. by Ielham Hadad (382805)