Straightforward and Ultrastable Surface Modification of Microfluidic Chips with Norepinephrine Bitartrate Improves Performance in Immunoassays by Haiying Shen (4906882)

“…A one-step modification by using norepinephrine bitartrate monohydrate as a modification reagent is completed at room temperature. …”

Supplemental Figure S2 from A Bis-Indole–Derived NR4A1 Antagonist Induces PD-L1 Degradation and Enhances Antitumor Immunity by Keshav Karki (14944981)

SIRT1 inhibition in dissociated E12.5 neocortical neurons enhanced SCPN/CSN subtype refinement, increasing the number of CTIP2-expressing, SATB2-negative neurons at the expense of... by Cameron Sadegh (11378606)

“…<p>(A) Representative image of E12.5 primary dissociated neocortical cells following six days of culture and representative immunostaining with CTIP2 and SATB2. …”

Total MB231/HBMEC-60 and MB231/HPMEC adhesion forces in different EC growing states for three cell-cell contact times. by Leike Xie (1317108)

KIF2C/MCAK a prognostic biomarker and its oncogenic potential in malignant progression, and prognosis of cancer patients: a systematic review and meta-analysis as biomarker by Nina-Naomi Kreis (460814)

“…All meta-analyses showed poor prognosis for cancer patients with KIF2C^high expression, associated with a decreased overall survival and reduced disease-free survival, indicating KIF2C’s oncogenic potential in malignant progression and as a prognostic marker. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…Subsequent synthesis and enzyme- and cell-based assays confirm new, mid-micromolar inhibitors of <i>Tb</i>PTR1 with low toxicity. In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…Subsequent synthesis and enzyme- and cell-based assays confirm new, mid-micromolar inhibitors of <i>Tb</i>PTR1 with low toxicity. In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…Subsequent synthesis and enzyme- and cell-based assays confirm new, mid-micromolar inhibitors of <i>Tb</i>PTR1 with low toxicity. In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…Subsequent synthesis and enzyme- and cell-based assays confirm new, mid-micromolar inhibitors of <i>Tb</i>PTR1 with low toxicity. In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…Subsequent synthesis and enzyme- and cell-based assays confirm new, mid-micromolar inhibitors of <i>Tb</i>PTR1 with low toxicity. In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…Subsequent synthesis and enzyme- and cell-based assays confirm new, mid-micromolar inhibitors of <i>Tb</i>PTR1 with low toxicity. In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…Subsequent synthesis and enzyme- and cell-based assays confirm new, mid-micromolar inhibitors of <i>Tb</i>PTR1 with low toxicity. In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…Subsequent synthesis and enzyme- and cell-based assays confirm new, mid-micromolar inhibitors of <i>Tb</i>PTR1 with low toxicity. In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Bringing Macromolecules into Cells and Evading Endosomes by Oxidized Carbon Nanoparticles by Sunatda Arayachukiat (1675165)

Silencing of Nb<i>eIF4A</i> inhibits <i>Turnip mosaic virus</i> infection of <i>N</i>. <i>benthamiana</i> plants and promotes the degradation of viral NIb protein. by Xiangxiang Zhang (498122)

“…In TuMV-GFP-inoculated leaves of Nb<i>eIF4A</i>-silenced plants, the number of infection foci decreased significantly at 3 dpi. …”

Image_1_OLFML2B Is a Robust Prognostic Biomarker in Bladder Cancer Through Genome-Wide Screening: A Study Based on Seven Cohorts.tif by Jiaxing Lin (1581886)

“…</p>Results<p>We identified OLFML2B as a robust prognostic marker for bladder cancer in five cohorts. …”

Table_1_OLFML2B Is a Robust Prognostic Biomarker in Bladder Cancer Through Genome-Wide Screening: A Study Based on Seven Cohorts.xlsx by Jiaxing Lin (1581886)

“…</p>Results<p>We identified OLFML2B as a robust prognostic marker for bladder cancer in five cohorts. …”

Six-year positive effects of a mindfulness-based intervention on mindfulness, coping and well-being in medical and psychology students; Results from a randomized controlled trial by Michael de Vibe (5136401)

“…</p><p><b>Trial registration:</b> Clinicaltrials.gov <a href="https://clinicaltrials.gov/ct2/show/NCT00892138" target="_blank">NCT00892138</a></p></div>…”

Towards a Better Understanding of the Effects of UV on Atlantic Walruses, <i>Odobenus rosmarus rosmarus</i>: A Study Combining Histological Data with Local Ecological Knowledge by Laura M. Martinez-Levasseur (2601664)

“…However, walruses face varied environmental threats including rising sea-water temperatures and decreasing ice cover. An underappreciated threat may be the large amount of solar ultraviolet radiation (UV) that continues to reach the Arctic as a result of ozone loss. …”

Accuracy differences between training and test questions obtained from computer simulations of group judgments. by Masaru Shirasuna (14755745)