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Spatial information is significantly decreased in dCA1 and vCA1 in APP/PS1 mice.
Published 2024“…Histograms show the mean firing rate for the corresponding neuron along each segment of the virtual track. (B) In dCA1, spatial information was decreased in APP/PS1 mice relative to C57BL/6 controls (mean ± std: C57BL/6 = 0.132 ± 0.048, APP/PS1 = 0.128 ± 0.051, p < 0.005, two-sided Wilcoxon rank-sum test, n<sub>C57BL/6</sub> = 305 units from 5 recording sessions, n<sub>APP/PS1</sub> = 180 units from 4 recording sessions). …”
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Biases in larger populations.
Published 2025“…Threshold parameter <i>c</i> = − 0 . 1 for the rectified cosine tuning with 4 neurons, and width <i>w</i> was 1 for von Mises tuning. …”
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Spatial information of excitatory neurons in APP/PS1 mice are decreased in dCA1 and vCA1.
Published 2024“…<p>(A) In dCA1, spatial information was decreased in APP/PS1 mice relative to C57BL/6 controls (mean ± std: C57BL/6 = 0.134 ± 0.050, APP/PS1 = 0.132 ± 0.054, p < 0.01, two-sided Wilcoxon rank-sum test, n<sub>C57BL/6</sub> = 229 units from 5 recording sessions, n<sub>APP/PS1</sub> = 124 units from 4 recording sessions). …”
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A lysine-restricted diet ameliorates obesity via enrichment of Parabacteroides goldsteinii and 1,4-methylimidazoleacetic acid
Published 2025“…Mechanistically, we show that MIAA inhibits the expression of the demethylase FTO, leading to increased m6A modifications on Slc2a4 mRNA via the reader protein YTHDC1. …”
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M<sup>6</sup>A-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/ VEGFA/Akt signaling
Published 2022“…However, the exact role of m<sup>6</sup>A induced LIFR-AS1 in pancreatic cancer (PC) and its potential molecular mechanisms remain largely unknown. …”
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Active spread of mtDNAs in the network can increase and decrease cell-to-cell variability from cell divisions.
Published 2023“…The three columns for each panel give decreasing network heterogeneity, expressed via different seed numbers, 4, 16 and 64 (more seed points give a more homogeneous network). …”
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Deletion of murine <i>Rhoh</i> leads to de-repression of <i>Bcl-6</i> via decreased KAISO levels and accelerates a malignancy phenotype in a murine model of lymphoma
Published 2022“…These findings suggest a previously unidentified regulatory role of RhoH in the proliferation of tumour cells via altered BCL-6 expression. (250)</p>…”
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