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The proportion of ALDH+ cells progressively increases while CGA+ cells markedly decreases in <i>APC</i>-mutant colon tissues from FAP patients.
Published 2020“…Results show that, in normal crypts, the distribution and proportion of cells staining for ALDH1 and CGA are very similar. In contrast, in <i>APC</i>-mutant tissues from FAP patients, the proportion of ALDH+ cells progressively increases while CGA+ cells markedly decreases. …”
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Cinacalcet administered early in the inactive phase markedly decrease parathyroid Ki-67 index.
Published 2025Subjects: -
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Deletion of Hhp2 markedly increased Sre1 activity.
Published 2020“…<p>Deletion of <i>hhp2</i><sup>+</sup> gene markedly increased Sre1 activity in the presence/absence of CLZ (2 μg/ml to 8 μg/ml) (A), TER (2 μg/ml to 8 μg/ml) (B) or CoCl<sub>2</sub> (0.08 mM to 0.32 mM) (C). …”
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Deletion of microglial NKCC1 markedly impacts on baseline cell morphology and alters transformation to reactive microglia.
Published 2022“…(<b>C)</b> NKCC1 mRNA levels in isolated NKCC1 KO microglia was markedly reduced in comparison to WT cells. …”