Chronic colitis induces marked changes in protein expression in the adult heart and blood. by Yanbo Tang (11457519)

The parameters of gas exchange markedly decreased in maize <i>zmstomagen1/2</i> mutant compared with in wild type (WT). by Juan-Juan Xu (18590868)

The proportion of ALDH+ cells progressively increases while CGA+ cells markedly decreases in <i>APC</i>-mutant colon tissues from FAP patients. by Tao Zhang (43681)

“…Results show that, in normal crypts, the distribution and proportion of cells staining for ALDH1 and CGA are very similar. In contrast, in <i>APC</i>-mutant tissues from FAP patients, the proportion of ALDH+ cells progressively increases while CGA+ cells markedly decreases. …”

3D interactions between the ligand and the protein_DNA complex in the first (C1) and second (C2) clusters. by Ahmed A. Gaber (13302308)

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Cinacalcet administered early in the inactive phase markedly decrease parathyroid Ki-67 index. by Søren Egstrand (10906087)

De-repression of gene expression and responsive histone marks. by Dana Lau-Corona (8861900)

“…(<b>C</b>) Shown at the right are 8 different combinations of histone mark changes, one of which was assigned to each E1/E2-KO-responsive gene based on whether there was a decrease in H3K27me3 marks at either the gene body or promoter region, and/or an induction of H3K27ac marks or of H3K4me1 marks, as determined by GREAT analysis (see <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1008796#sec012" target="_blank">Methods</a>). …”

Region-specific gain and loss of repressive marks in aged somatic tissues. by Cheng-Lin Li (3620321)

<i>RTTN</i>-mutated organoids exhibit decreased proliferation and increased cell death at early stages. by Justine Guguin (9088672)

Withdrawal of Type I JAKinibs increased STAT phosphorylation, a phenomenon present but markedly lower in Type II JAKinibs. by Ilya Gurevic (1326786)

miRNA 221 improved left ventricular contractile function in MIRI mice. by Hongyu Li (1332669)

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Altered expression of genes related to Ca²⁺ cycling or myocardial contraction. by Hongyu Li (1332669)

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miRNA 221 alleviated calcium overload in myocardium and inhibited the expression of apoptosis-related genes in MIRI mice. by Hongyu Li (1332669)

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miRNA 221 alleviated myocardial injury and inhibited apoptosis and necrosis of cardiac cells in MIRI mice. by Hongyu Li (1332669)

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Genes associated with androgen-induced decrease in H3K27me3 mark in the gene body and overlapping with promoters and distal enhancers involving long-range regulation of gene expres... by Sambit Roy (5463899)

Pericentric heterochromatin structural integrity is disrupted in the absence of CFDP1 due to loss of core heterochromatin protein, HP1α and H3K9me3 marks. by Gokul Gopinathan (7930679)

Calpain activation, Hsp70.1 cleavage, and cathepsin B leakage. by Piyakarn Boontem (11663090)

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Deletion of microglial NKCC1 markedly impacts on baseline cell morphology and alters transformation to reactive microglia. by Krisztina Tóth (12009827)

“…(<b>C)</b> NKCC1 mRNA levels in isolated NKCC1 KO microglia was markedly reduced in comparison to WT cells. …”

<b>Effect of Marked Weight Loss on Adipose Tissue Biology in People with Obesity and Type 2 Diabetes</b> by Dmitri Samovski (305400)

“…</p><p dir="ltr"><b>Results: </b>Weight loss: <a href="" target="_blank">i) </a><a href="" target="_blank">decreased adipose tissue </a>expression of genes related to extracellular matrix remodeling; ii) decreased adipose tissue expression of SERPINE 1 which encodes plasminogen activator inhibitor-1 (PAI-1); iii) did not decrease adipose tissue immune cell content or expression of genes involved in inflammation; iv) decreased adipose tissue ceramide content; v) decreased plasma <a href="" target="_blank">PAI-1 </a>and leptin concentrations and increased plasma high-molecular weight (HMW) adiponectin; and vi) decreased plasma small extracellular vesicle (sEV) concentration and the sEV content of microRNAs proposed to inhibit insulin action, and completely reversed the inhibitory effect of plasma sEVs on insulin signaling in myotubes.…”

Nemp1 KO mice display increased splenic stress erythropoiesis. by Didier Hodzic (132944)

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Impact of CMS121 and C75 on HSV-1 entry into Vero cells. by Camilla Albano (16446679)

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