Chronic colitis induces marked changes in protein expression in the adult heart and blood. by Yanbo Tang (11457519)

Cinacalcet administered early in the inactive phase markedly decrease parathyroid Ki-67 index. by Søren Egstrand (10906087)

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The proportion of ALDH+ cells progressively increases while CGA+ cells markedly decreases in <i>APC</i>-mutant colon tissues from FAP patients. by Tao Zhang (43681)

“…Results show that, in normal crypts, the distribution and proportion of cells staining for ALDH1 and CGA are very similar. In contrast, in <i>APC</i>-mutant tissues from FAP patients, the proportion of ALDH+ cells progressively increases while CGA+ cells markedly decreases. …”

The parameters of gas exchange markedly decreased in maize <i>zmstomagen1/2</i> mutant compared with in wild type (WT). by Juan-Juan Xu (18590868)

<i>RTTN</i>-mutated organoids exhibit decreased proliferation and increased cell death at early stages. by Justine Guguin (9088672)

3D interactions between the ligand and the protein_DNA complex in the first (C1) and second (C2) clusters. by Ahmed A. Gaber (13302308)

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Calpain activation, Hsp70.1 cleavage, and cathepsin B leakage. by Piyakarn Boontem (11663090)

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Nemp1 KO mice display increased splenic stress erythropoiesis. by Didier Hodzic (132944)

Withdrawal of Type I JAKinibs increased STAT phosphorylation, a phenomenon present but markedly lower in Type II JAKinibs. by Ilya Gurevic (1326786)

<i>Plasmodium falciparum</i> infection increases VWF and active VWF levels. by Shengshi Huang (13104571)

De-repression of gene expression and responsive histone marks. by Dana Lau-Corona (8861900)

“…<p>(<b>A</b>) Number of sites that show a significant decrease (Down) or a significant increase (Up) in each histone mark in E1/E2-KO male and E1/E2-KO female liver compared to sex-matched control liver. …”

PD-1 deficiency does obviously not change B cell and CD11b⁺ myeloid cell IHC staining in livers following <i>S</i>. <i>japonicum</i> infection. by Liaoxun Lu (179293)

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Genes associated with androgen-induced decrease in H3K27me3 mark in the gene body and overlapping with promoters and distal enhancers involving long-range regulation of gene expres... by Sambit Roy (5463899)

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Fig 1 - by Piyakarn Boontem (11663090)

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ComBat normalization markedly increases cross-study prediction when the studies have batch effects when using LASSO classifiers. by Yilin Gao (4335571)

ComBat normalization markedly increases cross-study prediction when the studies have batch effects when using XGBoost classifiers. by Yilin Gao (4335571)

<b>Effect of Marked Weight Loss on Adipose Tissue Biology in People with Obesity and Type 2 Diabetes</b> by Dmitri Samovski (305400)

“…</p><p dir="ltr"><b>Results: </b>Weight loss: <a href="" target="_blank">i) </a><a href="" target="_blank">decreased adipose tissue </a>expression of genes related to extracellular matrix remodeling; ii) decreased adipose tissue expression of SERPINE 1 which encodes plasminogen activator inhibitor-1 (PAI-1); iii) did not decrease adipose tissue immune cell content or expression of genes involved in inflammation; iv) decreased adipose tissue ceramide content; v) decreased plasma <a href="" target="_blank">PAI-1 </a>and leptin concentrations and increased plasma high-molecular weight (HMW) adiponectin; and vi) decreased plasma small extracellular vesicle (sEV) concentration and the sEV content of microRNAs proposed to inhibit insulin action, and completely reversed the inhibitory effect of plasma sEVs on insulin signaling in myotubes.…”

Deletion of microglial NKCC1 markedly impacts on baseline cell morphology and alters transformation to reactive microglia. by Krisztina Tóth (12009827)

“…(<b>C)</b> NKCC1 mRNA levels in isolated NKCC1 KO microglia was markedly reduced in comparison to WT cells. …”

Increase of T cell presence in the liver of PD-1-deficient mice infected with <i>S</i>. <i>japonicum</i> for 8 weeks. by Liaoxun Lu (179293)

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Region-specific gain and loss of repressive marks in aged somatic tissues. by Cheng-Lin Li (3620321)