Biological characteristics of <i>V. parahaemolyticus</i> strains with the modified promoters. by Xiaojun Zhong (6398279)

“…(<b>C</b>) Deletion of the <i>ttrR</i> box decreased the colonization of <i>V. parahaemolyticus</i>. …”

<i>TgFPPS</i> knockout parasites have a mitochondrial defect. by Zhu-Hong Li (473272)

“…Other experimental conditions are under <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1003665#s4" target="_blank">Materials and Methods</a>. (At 1 hour: <i>*Δfpps vs Δku80</i>, P = 0.002, <i>*Δfpps vs Δfpps-cm:</i> P = 0.0004) <b><i>C</i></b><b>,</b> Fluorescence analysis of <i>Δku80</i> and <i>Δfpps</i> tachyzoites stained with JC1, showing decrease in mitochondrial membrane potential of <i>Δfpps</i> tachyzoites (note the decrease in red fluorescence).…”

S1 Graphical abstract - by Faiza Alam (383681)

“…</p><p>Conclusions</p><p>Deficiency of VD is associated with a decrease in SIRT1 and other antioxidants, which may deter natural reproductive functions leading to infertility. …”

Definition of pressure drop-induced vasodilatation <i>(PDiVD)</i>. by Zhenghui Wang (720639)

“…The vertical gray shaded area demonstrates that the lower CA limit could stay at the same blood pressure value even when the CA curve would be flatter, meaning that the same lower CA limit would be associated with less perfusion. …”

sNPF peptides inhibition of forskolin-stimulated cAMP accumulation in CHO-K1 cells stably transformed with the <i>S. invicta</i> sNPF receptor (<i>Si</i>sNPFR-C6E8). by Prati Bajracharya (643415)

“…<p><b>A.</b> Independent dosage-response curves of <i>S. invicta</i> sNPF1 [SLRSALAAGHLRYa (13 a.a. residues); dashed line] and sNPF2 [SALAAGHLRYa (ten a.a. residues); solid line]. …”

GLP-1 fails to rescue apoptosis in ENPP1 transfected cells. by Nunzia Caporarello (221943)

“…Cells were treated with staurosporine (0.25 μmol/l, 2 hours) in the absence or presence of 100 nmol/l GLP-1. Treatment with GLP-1 significantly decreased apoptosis induced by staurosporine in INS-1E-neo and in βTC-1-neo cells but not in INS-1E-ENPP1 and in βTC-1-ENPP1 cells. …”

The <i>ENT2</i> knockout effects on CRC proliferation and survival. by Safaa M. Naes (22075434)

“…(F) Cell proliferation of DLD1/KO cells. Data are presented as means ± SD and expressed as % relative to control cells. * indicates a significant difference between NTC vs. …”

Alternative splicing of UNC-62 generates intestine-specific <i>unc-62(7a)</i> and neuronal/hypodermal-specific <i>unc-62(7b)</i> isoforms. by Eric L. Van Nostrand (30730)

“…(B) UNC-62(7a):GFP expression decreases between day 1 and day 8 of adulthood. Strain contains <i>glo-4(ok623)</i> to reduce gut autofluorescence, and expression was quantified only in the first pair of intestinal nuclei (dotted red circles). …”

Silencing of <i>NbUBL5s</i> facilitates the infection of RSV. by Binghua Chen (236328)

“…B. qRT-PCR revealed that the expression of <i>NbUBL5s</i> in TRV:UBL5s-infected plants was decreased to 20% of that in the control plants treated with TRV:00, indicating the silencing of <i>NbUBL5s</i>. …”

Validation of ALDH1A3 as target of miR-187. by Irene Casanova-Salas (738137)

“…Putative miR-187 binding sites were found in ALDH1A3 5’UTR region (i), coding region (CDS) (ii and iii) and 3’UTR (iv). …”

<i>nhr-62</i> regulates a DR-induced lipase and autophagy. by Bree N. Heestand (437346)

“…See <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003651#pgen.1003651.s005" target="_blank">Figure S5</a> for additional experiments. (B) <i>C40H1.8</i> RNAi did not decrease the lifespan of <i>eat-2;nhr-62</i> worms compared to <i>eat-2;nhr-62</i> (<i>gfpi</i>). …”

<i>mig-21</i> sensitizes adult DTCs to polarizing signals. by Xin Li (51274)

“…Since our results do not strongly support an interaction between <i>mig-21</i> and <i>ced-10</i> or <i>mig-2</i> (S1C–S1E Fig), we have chosen to leave <i>ced-10</i> and <i>mig-2</i> out of this pathway diagram.…”

Microglial process dynamics and injury-induced process recruitment are altered by bumetanide. by Krisztina Tóth (12009827)

“…(<b>E)</b> Calculated postlesion velocities of microglial process recruitment using automated image analysis followed by model fitting. Data show a significant decrease (31.7%) in mean frontline velocity of cells with Bum administration. …”

DataSheet1_Glucagon-like peptide-1 receptor agonists as add-on therapy to insulin for type 1 diabetes mellitus.zip by Xinrui Tan (12089750)

“…<p>Background: To assess the efficacy and safety of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) used as an adjunct to insulin therapy in adults with type 1 diabetes.…”

Transcriptional expression of Nrf1 and its reporter is unaffected by SREBP1 or rapamycin. by Keli Liu (5937368)

“…<p>(A to D) Two cell lines of HepG2 (<i>A</i>, <i>B</i>) and L7702 (<i>C</i>, <i>D</i>), that had been transfected with: (<i>A</i>, <i>C</i>) siNC (a negative control) or siSREBP1; (<i>B</i>, <i>D</i>) a pSREBP1 expression construct or empty plasmid, were subjected to real-time qPCR analysis of mRNA expression levels of <i>SREBP1</i> and <i>Nrf1</i> (n = 3×3; with significant decreases (*, <i>p</i><0.01), significant increases ($, <i>p</i><0.01), or no significances (NS)). …”

Data_Sheet_1_The Associations of Plasma Carotenoids and Vitamins With Risk of Age-Related Macular Degeneration: Results From a Matched Case-Control Study in China and Meta-Analysis... by Hong Jiang (79543)

“…Plasma concentrations of examined carotenoids and vitamins were significantly lower in patients with AMD than those in controls. After a multivariate adjustment for body mass index, blood cholesterol, and other lifestyle risk factors, higher lutein/zeaxanthin content in plasma was significantly associated with a decreased risk of AMD, and the odds ratio (OR) comparing the top and bottom tertiles was 0.21 (95% CI: 0.05, 0.84; P_trend = 0.024). …”

Mapping the <i>p54^nrb</i> promoter region that mediates the effects of MIA/CD-RAP on <i>p54^nrb</i> transcription. by Rainer Schmid (496848)

“…The ratio of the human <i>p54^nrb</i> promoter activity comparing WT and MIA-/- mMSCs significantly decreased in deletions involving the region between −7079 and −7037 bp, identifying this 42 bp DNA region as the mediator of MIA/CD-RAP up-regulation of <i>p54^nrb</i> promoter activity (*p<0.05). …”

The effect of glibenclamide on channel activity at +20, 0 and -20 mV. by Sajjad Salari (736104)

“…Histogram bars show current amplitudes and P_o of reconstituted channels in absence or presence of glibenclamide. The addition of 50 μM glibenclamide resulted in a decreased current jump amplitude and a reduction in P_o. 100 μM glibenclamide caused a total channel inhibition at +20 and 0 mV (n = 5), but was ineffective at -20 mV. …”

Image_3_DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation.tif by Majd Jawad (12157533)

“…By data mining with publicly accessible cancer genomics databases and a clinical genomic database from a tertiary medical institution, DNMT3A R882 mutations were found to be enriched in AML (53% of all DNMT3A mutations) but decreased in frequency in clonal hematopoiesis of indeterminate potential (CHIP) (10.6%) or other myeloid neoplasms including MDS (27%) (p<.001). …”

Image_1_DNMT3A R882 Mutations Confer Unique Clinicopathologic Features in MDS Including a High Risk of AML Transformation.tif by Majd Jawad (12157533)

“…By data mining with publicly accessible cancer genomics databases and a clinical genomic database from a tertiary medical institution, DNMT3A R882 mutations were found to be enriched in AML (53% of all DNMT3A mutations) but decreased in frequency in clonal hematopoiesis of indeterminate potential (CHIP) (10.6%) or other myeloid neoplasms including MDS (27%) (p<.001). …”