FoxO1 deacetylation couples Sirt1 action to POMC expression. by Işin Çakir (256194)

“…(<i>C)</i> Inhibition of Sirt1 activity decreases FoxO1 activity <i>in vivo</i>. …”

In combination with <i>Gem3</i>^<i>BART</i>, Gemin5 knockdown triggers lethality whereas a reduction in the gene copy number of Gemin5 provokes impaired flight. by Rebecca M. Borg (758474)

“…In a heterozygous Gemin5 deficient background brought about by a chromosomal deletion (<i>Df(2R)exu1</i><b>)</b>, the hypomorphic <i>Gem3</i>^<i>BART</i> motor phenotype becomes apparent on the day 5 time point and intensifies with age (middle panel). …”

Data_Sheet_1_The effect of omega-3 fatty acids and its combination with statins on lipid profile in patients with hypertriglyceridemia: A systematic review and meta-analysis of ran... by Yunjiao Yang (4966963)

“…When OM3-FA was combined with statins, significant reductions were observed in the concentrations of TG (MD: −29.63, 95% CI: −36.24 to −23.02; p < 0.001), TC (MD: −6.87, 95% CI: −9.30 to −4.45, p < 0.001), VLDL-C (−20.13, 95% CI: −24.76 to −15.50; p < 0.001), non-HDL-C (MD: −8.71, 95% CI: −11.45 to −5.98; p < 0.001), Apo-B (MD: −3.50, 95% CI: −5.37 to −1.64; p < 0.001), and Apo-AI (MD: −2.01, 95% CI: −3.07 to −0.95; p < 0.001). …”

Poliovirus induces autophagic signaling independent of the ULK1 complex by Angel Corona Velazquez (5539916)

“…This means that SQSTM1, normally used to monitor autophagic degradation, cannot be used to accurately monitor degradation during poliovirus infection. …”

<i>Self-stimulation driven by VTA dopamine neurons is attenuated by intra-NAc D1 and D2 receptor antagonists.</i> by Elizabeth E. Steinberg (551612)

“…Relative to saline, all drug treatments significantly reduced responding (one-way repeated measures ANOVA, main effect of treatment <i>p</i><0.001, **post-hoc test vs. saline <i>p</i><0.01). …”

5-Choice Serial Reaction Time Task (5-CSRTT) Results Longitudinally for <i>Hdh</i>^{<i>Q111/+</i>} animals over 18 months of testing. by Emma Yhnell (3193398)

“…Animals initiated significantly fewer trials as the stimulus length was decreased, at all ages. <i>Hdh</i>^{<i>Q111/+</i>} animals initiated significantly fewer trials than wild type animals, largely due to the magnitude of difference in the number of initiated trials at 18 months of age. …”

Fig 5 - by Israel Luis (13916706)

Fig 4 - by Israel Luis (13916706)

DataSheet1_Calmodulin mutations affecting Gly114 impair binding to the NaV1.5 IQ-domain.docx by Malene Brohus (840080)

“…The impact was most severe at low and intermediate Ca²⁺ concentrations (up to 4 µM) resulting in more than a 50-fold reduction in Na_V1.5 binding affinity, and a smaller 1.5 to 11-fold reduction at high Ca²⁺ concentrations (25–400 µM). …”

Effects of co-use of marijuana. by Martina Reske (755280)

Viral Infection of Human Lung Macrophages Increases PDL1 Expression via IFNβ by Karl J. Staples (457228)

“…Knockdown of IFNβ by siRNA, resulted in a 37.5% reduction in IFNβ gene expression in response to infection, and a significant decrease in PDL1 mRNA. Furthermore, when MDM were incubated with IFNβ, this cytokine caused increased expression of PDL1 mRNA. …”

Recursive sites aid in efficient splicing of long <i>Drosophila</i> introns. by Athma A. Pai (119315)

“…<p><b>(A)</b> The percentage of splice junction reads (mean percentage across recursive introns; <i>x-axis</i>) that span the exon-exon boundary (5' splice site– 3' splice site; <i>dark blue</i>), a 5' splice and recursive site (<i>light blue</i>), two recursive sites (<i>gold</i>), and a recursive site and 3' splice site (<i>yellow</i>) across different labeling periods (<i>y-axis</i>). …”

Impairment of the autophagy-lysosome pathway in <i>GBA</i>^-/- medaka. by Norihito Uemura (716962)

“…Morphologically abnormal organelles with decreased Cathepsin D staining intensity were observed in <i>GBA</i>^-/- medaka (arrows). …”

Repeated <i>Ascaris</i> challenge causes cellular changes to the gastric mucosa. by Yifan Wu (1702936)

“…<p>Bulk RNA sequencing shows differential expression represented by z-score (A) for genes in stomach tissue associated with cellular reprogramming and development of pyloric metaplasia following mucosal injury including relatively decreased expression of atp4a and atp4b and increased expression of tff2 in the repeat <i>Ascaris</i> mouse models compared to naïve controls. …”

Impairments in recognition memory and mesohippocampal dopaminergic fibers induced in the mouse ventral hippocampus after chronic GBR12935 infusions. by Jill Rocchetti (16883936)

Dynamic distribution decomposition applied to Nanog-Neo cell line data taken from Zunder <i>et. al</i>. [28]. by Jake P. Taylor-King (8282190)

“…Fitting error plot showing log₁₀ transformed percentage error plotted against time for different values of <i>α</i> (described in main text); (b.) log-log plot of mean fitting error plotted against −log₁₀(<i>α</i>), mean error decreases as alpha decreases; (c.) complex plot of eigenvalues λ of Perron–Frobenius matrix <i>P</i> for different values of <i>α</i>; (d.) …”

Pyruvate oxidase-deficiency increases susceptibility of <i>Spn</i> to OSCN^-. by Aaron D. Gingerich (9188396)

“…Mean, n = 2. <b>(B)</b> OSCN^—mediated (1st line™) killing of the TIGR4 Δ<i>spxB Spn</i> strain was measured by the microplate-based growth assay in presence or absence of catalase (n = 5). …”

Sample size estimation based on preliminary date. by Jacquelyn Y. Taylor (6386456)

Expression of 5HT-2AR, 2BR, 3AR, and 3BR mRNA in the mid colon. by Ji Eun Kim (403026)

Expression of c-kit, nNOS, NSE, and PGP9.5. by Ji Eun Kim (403026)