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Molecular and Structural Analysis of Mosaic Variants of Penicillin-Binding Protein 2 Conferring Decreased Susceptibility to Expanded-Spectrum Cephalosporins in <i>Neisseria gonorrh...
Published 2010“…Agents Chemother. 50</i>, 3638−3645]. However, we observed that the minimum inhibitory concentrations (MICs) of penicillin, ceftriaxone, and cefixime for a wild-type strain (FA19) containing a <i>penA</i> gene with these three mutations increased only 1.5-, 1.5-, and 3.5-fold, respectively. …”
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Relationship between Differential Hepatic microRNA Expression and Decreased Hepatic Cytochrome P450 3A Activity in Cirrhosis
Published 2013“…In this study, we examined if certain microRNAs (miRNA) are associated with decreased hepatic CYP3A activity in cirrhosis.…”
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Cinacalcet administered early in the inactive phase markedly decrease parathyroid Ki-67 index.
Published 2025“…<p>(A) Ki-67 expression in parathyroid glands of rats with CKD-induced sHPT treated with Cinacalcet either early in the inactive light phase (<i>Cina1</i>; N = 10) or early in the active dark phase (<i>Cina2</i>; N = 9) compared to untreated rats with sHPT investigated at similar time points (<i>PNX1</i>; N = 7 and <i>PNX2</i>; N = 7, respective) and to normal rats investigated at similar time points (<i>ctrl1</i>; N = 9 and <i>ctrl2</i>; N = 7, respective). …”
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Capzb2 coimmunoprecipitates with βIII-tubulin in brain lysates and decreases tubulin polymerization in vitro.
Published 2009“…Each point depicted represents the average of 20 OD readings obtained for each Capzb2 concentration examined (0, 0.1, 0.5, 1, and 10 µM) during the interval 180–750 s; <i>R</i><sup>2</sup> (correlation coefficient) = 0.99. …”
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Blockade of mTORC2 decreased TRPC6-dependent calcium influx in podocytes (confocal microscopy).
Published 2014“…(B, E) The images in rows 1, 2, and 3 are magnifications of cells 1, 2, and 3 marked in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0112972#pone-0112972-g004" target="_blank">Figure 4A</a>, respectively, depicting the changes in fluorescence over shorter periods. …”
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Drugs which cluster on the 'anxiolytic' group decrease 5-HT turnover in the brain.
Published 2014“…Bars represent mean (B) Correlation between turnover rates (<i>Y</i>-axis) and time spent in the white compartment (<i>X</i>-axis) for vehicle- and drug-treated animals (<i>n</i> = 4 for each point). …”
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Decrease in Vitamin D Status in the Greenlandic Adult Population from 1987–2010
Published 2014“…Age (2.0% per year increase; CI: 1.7, 2.2), female gender (7.1%; CI: 2.0; 12.5), alcohol intake (0.2% per increase in drinks/week; 0.0; 0.4), and traditional diet (10.0% per 100 g/d increase; CI: 7.9; 12.1) were associated with increased serum 25(OH)D3, whereas smoking (−11.6%; CI: −16.2; −6.9), BMI (−0.6%; CI: −1.1; −0.2) and latitude (−0.7% per degree increase; CI: −1.3; −0.2) were associated with decreased concentrations.</p><p>Conclusion</p><p>We identified a remarkable decrease in vitamin D status from 1987 to 2005–2010 and a presently low vitamin D status among Inuit in Greenland. …”
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The introduction of mutualisms into assembled communities increases their connectance and complexity while decreasing their richness.
Published 2025“…(C) Mutualism also promotes an increase in network connectance when introduced into assembled communities, while stopping mutualistic interactions from entering an assembled system slowly decreases it. (D) As a result, the introduction of mutualistic interactions promotes a growth in complexity in communities where it was once established as low, while stopping the introduction of further mutualistic interactions causes a slight decrease in complexity. …”
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Netrin-1 overexpression increases HCV RNA and specific infectivity of HCV virions in vitro whereas Netrin-1 depletion decreases HCV RNA and specific infectivity in vitro.
Published 2016“…<b>G.</b> Assessment of <i>Netrin-1</i> mRNA knockdown. Cells were initially transfected with control and Netrin-1-specific siRNAs, then harvested at the indicated time points and processed for <i>Netrin-1</i> mRNA quantification by RT-qPCR or by immunoblotting in microsomes using an anti-Netrin-1 antibody (data are shown as mean ± standard deviation, <i>n</i> = 3, Mann-Whitney test, <i>p</i> < 0.05). …”
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