Probing the Histamine H₁ Receptor Binding Site to Explore Ligand Binding Kinetics by Sebastiaan Kuhne (1474948)

“…Ligand efficiency (LE) decreases upon the introduction of the negatively charged group, whereas kinetic efficiency (KE) increases up to 8.5-fold. …”

Probing the Histamine H₁ Receptor Binding Site to Explore Ligand Binding Kinetics by Sebastiaan Kuhne (1474948)

“…Ligand efficiency (LE) decreases upon the introduction of the negatively charged group, whereas kinetic efficiency (KE) increases up to 8.5-fold. …”

miR-UL112-3p inhibits TLR2-dependent activation of the NFκB pathway in THP1 cells. by Igor Landais (2213320)

“…<p>(A) Schematic of cell treatment. THP1 or NFκB luciferase reporter THP1 cells (THP1-NFκBRE-luc) were transfected with siRNA or miRNA mimics after being differentiated for 24hrs with TPA. …”

TLR2 3’UTR is targeted by HCMV miRNAs. by Igor Landais (2213320)

Generation of the parenchyma-fluid-interface (PFI) mask. by Juliana Zimmermann (10507091)

The N-terminal low complexity and PUF domains of Puf3 are critical for interaction with Pbp1. by Floortje van de Poll (15810877)

“…Transcript levels are shown in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1010774#pgen.1010774.s005" target="_blank">S5 Fig</a>.…”

Evidence for an HSF-1–dependent thermostat in WT animals. by Laetitia Chauve (8600553)

“…In the absence of stress, GFP is expressed exclusively in anterior cells and occasionally in tail neurons (arrowhead in A). The cells are neurons as they show axonal projections (in B, arrowhead points at a visible axonal projection). …”

Supplementary file 1_Early life predictors of child development at kindergarten: a structural equation model using a longitudinal cohort.docx by Sarah E. Turner (8478309)

“…Higher SES was related to a-0.26 (p-value =0.01) standardized decrease of EDI vulnerability, and this link was partially mediated through family stress at 3 years (10.6% mediated). …”

Quantitatively describing the downstream effects of an abrupt land cover transition: buffering effects of a forest remnant on a stream impacted by cattle grazing by Rafael Feijó-Lima (5666879)

Properties and ATRP Activity of Copper Complexes with Substituted Tris(2-pyridylmethyl)amine-Based Ligands by Aman Kaur (1481443)

“…Furthermore, cyclic voltammetry studies indicated a nearly stepwise decrease (Δ<i>E</i> ≈ 60 mV) of <i>E</i>_1/2 values relative to SCE (TPMA (−240 mV) > TPMA*¹ (−310 mV) > TPMA*² (−360 mV) > TPMA*³ (−420 mV)) on going from [Cu^II(TPMA)­Br]­[Br] to [Cu^II(TPMA*³)­Br]­[Br], confirming that the presence of electron-donating groups in the 4 (−OMe) and 3,5 (−Me) positions of the pyridine rings in TPMA increases the reducing ability of the corresponding copper­(I) complexes. …”

The influence of concomitant antiepileptic drugs on lamotrigine serum concentrations in Northwest Chinese Han population with epilepsy by Xiaonian Han (6208460)

“…Combination with enzyme-inducer AEDs, the mean steady-state LTG concentration could be decreased by 30.73% compared with LTG monotherapy. …”

Relative abundance and proportion of common ESBL coding genes between the experimental, validation-targeted, and validation-shotgun groups. by Dita Gudra (4439767)

CD8⁺ T-cells are essential for tumour growth suppression during IAV infection. by Philine Steinbach (17847521)

SIRT1 regulates fatty acid production leading to anti-viral innate immune response. by Srikanth Elesela (8501205)

Pharmacodynamic Effects of Canagliflozin, a Sodium Glucose Co-Transporter 2 Inhibitor, from a Randomized Study in Patients with Type 2 Diabetes by Sue Sha (622956)

“…Canagliflozin dose-dependently decreased RT_G, with maximal reductions to ∼4–5 mM (72–90 mg/dL). …”

Direct Observation of Anomalous Single-Molecule Enzyme Kinetics by Hung-Wing Li (1740712)

“…However, Mg²⁺ ion is no longer the limiting factor when its concentration is greater than 5 mM. A surprising result is that at all concentrations the decrease in intact DNA population as a function of time is linear rather than exponential. …”

A combinations of ohmic synaptic conductances determines the type of excitability for the neuron. by Ekaterina O. Morozova (3386927)

“…The bifurcation type changes at , which is called Bogdanov-Tackens point. B) SNIC bifurcation scenario for a low reversal potential of the ohmic synaptic current (<i>E</i>_<i>eff</i> = −90<i>mV</i>), (D) A smooth frequency decrease to 0 upon application of combined synaptic conductance, corresponding to type I excitability. …”

ToxR antagonizes H-NS function to control host colonization and biofilm formation. by Misha I. Kazi (3174750)

“…<p>(A) ChIP enrichment of H-NS on the indicated promoter regions in the presence (p<i>toxRS</i>) or absence (control) of <i>toxRS</i> ectopic expression. …”

Transgenic pmes-<i>Bmp4</i> reactivates Smad1/5/8 signaling in the dermal mesenchyme in <i>Gpr177^K14</i>/Tg-pmes-<i>Bmp4</i>. by Xiao-Jing Zhu (645748)

“…P-Smad1/5/8 activity (white arrowheads) is preferentially decreased in dermis of limb skin in <i>Gpr177^K14</i> mice and increased in dermis of <i>Gpr177^K14</i>/Tg-pmes-<i>Bmp4</i> mice (green arrowheads) (A–C). …”

Data_Sheet_1_Endothelial Phenotype Evoked by Low Dose Carvedilol in Pulmonary Hypertension.docx by Hoi I Cheong (6075230)