The weak activator Nrf1β/LCR-F1 is negatively regulated by its CTD. by Yiguo Zhang (512679)

“…The <i>left two panels</i> show western blotting of some of the above-transfected cell lysates with antibodies against either V5 (<b><i>a1</i></b>) or Xpress (<b><i>a2</i></b>). …”

Estimating Metabolic Fluxes Using a Maximum Network Flexibility Paradigm by Wout Megchelenbrink (523390)

“…By mapping measured flux data from central metabolism to the genome-scale models of <i>Escherichia coli</i> and <i>Saccharomyces cerevisiae</i> we show that i) indeed, most of the measured fluxes agree with a high adaptability of the network, ii) this result can be used to further reduce the space of feasible solutions iii) this reduced space improves the quantitative predictions made by FBA and contains a significantly larger fraction of the measured fluxes compared to the flux space that was reduced by a uniform sampling approach and iv) MMF can be used to select reactions in the network that contribute most to the steady-state flux space. …”

Changes of lung mRNAs related to the Notch Signaling Pathway were influenced by strain. by Yan Xu (14594)

“…(B) Genes encoding a number of key components in the Notch Signaling Pathway were expressed at significantly higher levels in A/J than in B6 mice at E18.5 (*: P<0.05). …”

Experiment 3. by Jiehui Qian (294581)

“…There was a significant difference between the illusory decrease of bar length of Experiment 2a, 2b and Experiment 3 (<i>p</i> = 0.03).…”

TRPV4 mediated calcium influx after stretch. by N. Pairet (5109128)

“…(B) Summary of the mean % Ca²⁺ response from the 60 sec after stretch, a 2.5 fold increase in the [Ca2+]_i was observed that was significantly decreased by 26% with the TRPV4 antagonist (1 <b>μ</b>M) GSK2193874 (184.5 ± 5.07 vs 248.6 ± 10.17). …”

Mapping of accessible sites in the target mglB mRNA by RNase T1 and rEGS libraries. by Gaoping Xiao (210986)

“…<p>A. Polyacrylamide gel electrophoresis of cleavage products of 5′end labeled mglB mRNA generated by RNase P holoenzyme and rEGSe or rEGSx libraries. …”

Rare coding variants pinpoint genes that control human hematological traits by Abdou Mousas (4336705)

“…We found 56 such rare coding or splice site variants at <i>P</i><5x10^-8, including 31 that are associated with a blood-cell phenotype for the first time. …”

The negative effect of lipid challenge on autophagy inhibits T cell responses by Ignacio Guerrero-Ros (6587345)

“…</p> <p><b>Abbreviations</b>: ACTB: actin, beta; ATG: autophagy-related; CDKN1B: cyclin-dependent kinase inhibitor 1B; HFD: high-fat diet; IFNG: interferon gamma; IL: interleukin; MAPK1/ERK2: mitogen-activated protein kinase 1; MAPK3/ERK1: mitogen-activated protein kinase 3; MAPK8/JNK: mitogen-activated protein kinase 8; LC3-I: non-conjugated form of MAP1LC3B; LC3-II: phosphatidylethanolamine-conjugated form of MAP1LC3B; MAP1LC3B: microtubule-associated protein 1 light chain 3 beta; MS: mass spectrometry; MTOR: mechanistic target of rapamycin kinase; NFATC2: nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2; NLRP3: NLR family, pyrin domain containing 3; OA: oleic acid; PI: propidium iodide; ROS: reactive oxygen species; STAT5A: signal transducer and activator of transcription 5A; TCR: T cell receptor; T_H1: T helper cell type 1</p>…”

Examples of four of the 53 stability motifs discovered by Reut Shalgi (11619)

“…Presented are mean half-life for each motif, and the -value on the hypothesis that they mediate a significant increase or decrease in half-life compared with the genome, resulting from a ranksum test. …”

Graph to show numbers of cells observed on the articular cartilage surface by Frances MD Henson (78253)

“…At day 11 and day 20 there was a significant decrease in the number of cells on the cartilage surface in the samples cultured in the presence of 100 ng/ml BMP-2 (*) compared to both control and SIL sections.…”

Treatment of xenograft tumors by chemotherapy. by Wolfgang Jäger (394799)

“…<p>A. Mice bearing UM-UC13 luc tumors showed a remarkable decrease in tumor volume after systemic therapy with a combination of gemcitabine and cisplatin starting on day #28 after inoculation, compared to PBS control (** = P<0.01). …”

Dopaminergic neurons present in the SNpc are reduced by half after MPTP intranigral microinjection. by Marcelo M.S. Lima (74920)

“…<p>A representative immunohistochemistry labeling of TH-ir neurons is shown in animals at the end of 5-day sleep-wake cycle recordings; (a) sham group (the inset square shows the specific region depicted in the panel below), (b) MPTP group (the inset square shows the specific region depicted in the panel below), (c) sham group in higher magnification (d) MPTP group in higher magnification, (e) bilateral quantification of the loss of TH-ir neurons in the SNpc, (f) the loss of TH-ir neurons in the SNpc correlated closely with the decrease of REM sleep on the first day of recording, subsequent to MPTP microinjection. …”

Temporal changes of TH levels in the striatum of PD-induced rats. by Gabriela P. Chaves-Kirsten (468145)

“…<p>TH levels in striatum of rats submitted to unilateral intrastriatal injections of 6-OHDA after 1, 5, 10, 20, and 60 days post-lesion (DPL). (A) Digital images of coronal sections of the dorsolateral striatum shows a decrease in the expression of TH on the 6-OHDA side, with a peak in 10 DPL (B) Digital images of coronal sections of the dorsolateral striatum at 60 DPL; the arrow indicates the site of infusion. …”

Development of lymphangioma in PAI-1 WT or PAI-1^−/− mice. by Françoise Bruyère (4734)

“…<p>A macroscopic decrease of lymphangioma is observed in PAI-1^−/− as compared to WT (A). …”

ATP and phosphocreatine in FVB and Mb hearts after TAC or sham surgery. by Jianxun Wang (290485)

“…TAC decreased the content of ATP (A) and PCr (B), however, the differences between FVB and Mb were not significant. …”

Graph to show numbers of cells captured in 3D gelatin scaffold ('Gelfoam') by Frances MD Henson (78253)

“…At day 11 and day 20 there were significantly reduced numbers of chondrocytes in the Gelfoam in the samples cultured in the presence of 100 ng/ml BMP-2 (*). At day 20 there was a significant decrease in cell numbers in all three experimental conditions.…”

Graph to show numbers of cells extruding out of the articular cartilage surface by Frances MD Henson (78253)

“…At day 11 there was a significant decrease in the number of cells extruding from the cartilage surface in the samples cultured in the presence of 100 ng/ml BMP-2 (*) compared to both control and SIL sections.…”

Transmission and perception of substrate-borne vibrations along <i>Aechmea magdalenae</i>, the roost plant of the katydid <i>D. gigliotosi</i>. by Heiner Römer (52699)

“…<p>When one leaf of the plant is stimulated with a sinusoidal stimulus at 10 Hz (at the position indicated by the large arrowhead), the induced vibrations of the plant differ substantially close to the source (distance 5 cm) and at a distance of 150 cm. …”

DMT1 from cells cultured for 2 days with different iron concentrations was determined by Western blot by Pabla Aguirre (6888)

“…</p><p>Copyright © 2005 Aguirre et al; licensee BioMed Central Ltd.</p> A continuous decrease in DMT1 expression was observed in the 1.5–80 μM Fe range. …”

Degradation of chromosome ends in strains containing <i>mec1</i> and <i>tlc1</i> mutations. by Vincent Pennaneach (261563)

“…(C) Telomere lengths in a RDKY3615 Can^s 5FOA^s strain, a <i>mec1 sml1 tlc1</i> Can1^r 5FOA^r post-senescence strain, a <i>mec1 sml1 lig4 tlc1</i> Can1^s 5FOA^s post-senescence strain, <i>mec1 sml1 tlc1</i> GCR strains (D4, U1 and D5) and <i>mec1 sml1 lig4 tlc1</i> GCR strains (D6, D7, D9 and D10) were analyzed by Southern blot with a poly(C_1-3/TG_1–3) radiolabelled probe hybridized to <i>Xho</i> I-digested genomic DNA. …”