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Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5‑ASA–PABA–MAC and 5‑ASA–PABA–Diamine for the T...
Published 2022“…Specifically, compound <b>20g</b> displayed a 3.67-fold decrease of plasma AUC<sub>(tofacitinib, 0–∞)</sub> and a 9.61-fold increase of colonic AUC<sub>(tofacitinib, 0–12h)</sub>, compared with tofacitinib at a molar equivalent oral dose. …”
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A PPARα Promoter Variant Impairs ERR-Dependent Transactivation and Decreases Mortality after Acute Coronary Ischemia in Patients with Diabetes
Published 2010“…<em>PPARA</em> A for both ERR-α and -γ (3.1 vs.1.9-fold; P<0.05). …”
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Image_5_Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells.TIF
Published 2020“…As factors, we found that the proportion of the CD11b<sup>–</sup>CD103<sup>+</sup>PD-L1<sup>high</sup> subset was decreased in aged mice compared with that in young mice and that RALDH enzyme activity was decreased in the CD11b<sup>–</sup>CD103<sup>+</sup>PD-L1<sup>high</sup> and CD11b<sup>+</sup>CD103<sup>+</sup>PD-L1<sup>high</sup> subsets. …”
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Table_1_FMT intervention decreases urine 5-HIAA levels: a randomized double-blind controlled study.DOCX
Published 2024“…However, in the placebo group, GSRS, CARS, and SRS scores showed no significant changes, while ABC scores decreased from 72 to 58.75 (p = 0.034). The FMT group also showed a significant reduction in urinary 5-hydroxyindoleacetic acid (5-HIAA) levels from 8.6 to 7.32 mg/L (p = 0.022), while other metabolites showed no significant changes.…”
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A Hierarchical Contact–Electrification Interface Based on Gradient Micro-/Nanostructured Hydrogel for Cardiovascular Disease Monitoring
Published 2025“…Consequently, the gradient micro-/nanostructured hydrogel, fabricated via electric field induction, enables the sensor’s high-sensitivity region to reach 1.1–52.2 kPa, a 5-fold improvement over that of comparable sensors. …”
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A Hierarchical Contact–Electrification Interface Based on Gradient Micro-/Nanostructured Hydrogel for Cardiovascular Disease Monitoring
Published 2025“…Consequently, the gradient micro-/nanostructured hydrogel, fabricated via electric field induction, enables the sensor’s high-sensitivity region to reach 1.1–52.2 kPa, a 5-fold improvement over that of comparable sensors. …”
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Maternal Hypoxia Decreases Capillary Supply and Increases Metabolic Inefficiency Leading to Divergence in Myocardial Oxygen Supply and Demand
Published 2015“…Hearts of male offspring subjected to Maternal Hypoxia showed a 20% decrease in cardiac output (<i>P</i><0.05), despite recording a 2-fold increase in glucose oxidation (<i>P</i><0.01) and 2.5-fold increase (<i>P</i><0.01) in palmitate oxidation. …”
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<i>Zip88E</i><sup><i>Δ/Δ</i></sup> larvae have decreased <i>MtnB</i>:<i>EYFP</i> expression.
Published 2017“…C) There is an approximate 5 fold decrease in <i>MtnB</i>:<i>EYFP</i> expression in <i>Zip88E</i><sup><i>Δ/Δ</i></sup> larvae compared to controls when raised on basal media. …”