Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5‑ASA–PABA–MAC and 5‑ASA–PABA–Diamine for the T... by Jiaxing Zhao (3965057)

“…Specifically, compound <b>20g</b> displayed a 3.67-fold decrease of plasma AUC_{(tofacitinib, 0–∞)} and a 9.61-fold increase of colonic AUC_{(tofacitinib, 0–12h)}, compared with tofacitinib at a molar equivalent oral dose. …”

A PPARα Promoter Variant Impairs ERR-Dependent Transactivation and Decreases Mortality after Acute Coronary Ischemia in Patients with Diabetes by Sharon Cresci (53599)

“…<em>PPARA</em> A for both ERR-α and -γ (3.1 vs.1.9-fold; P<0.05). …”

Image_5_Age-Dependent Decrease in the Induction of Regulatory T Cells Is Associated With Decreased Expression of RALDH2 in Mesenteric Lymph Node Dendritic Cells.TIF by Tomohiro Takano (9227690)

“…As factors, we found that the proportion of the CD11b^–CD103⁺PD-L1^high subset was decreased in aged mice compared with that in young mice and that RALDH enzyme activity was decreased in the CD11b^–CD103⁺PD-L1^high and CD11b⁺CD103⁺PD-L1^high subsets. …”

Table_1_FMT intervention decreases urine 5-HIAA levels: a randomized double-blind controlled study.DOCX by Lihong Wang (14991)

“…However, in the placebo group, GSRS, CARS, and SRS scores showed no significant changes, while ABC scores decreased from 72 to 58.75 (p = 0.034). The FMT group also showed a significant reduction in urinary 5-hydroxyindoleacetic acid (5-HIAA) levels from 8.6 to 7.32 mg/L (p = 0.022), while other metabolites showed no significant changes.…”

Image 1_Decreased activity in zebrafish larvae exposed to glyphosate-based herbicides during development—potential mediation by glucocorticoid receptor.pdf by S. Spulber (19335583)

“…Using a continuous developmental exposure regime, we show that wildtype larvae exposed to GBH display decreased spontaneous activity and attenuated response to environmental stimuli, a pattern of alteration similar to the one observed in gr^s357 mutant larvae. …”

The catalase enzyme response of <i>A</i>. <i>albopictus</i> larvae decreased (1.5-fold) in response to <i>M</i>. <i>robertsii</i>-derived copper nanoparticles. by Perumal Vivekanandhan (4863484)

Decreased Expression of MiRNA-204-5p Contributes to Glioma Progression and Promotes Glioma Cell Growth, Migration and Invasion by Zhiqiang Xia (764303)

Monocytes mediate LPS induced decrease of T cell proliferative response to OKT3. by Fanny Poujol (834338)

Rhox5 decreases UNC5C expression. by Mayumi Sugimoto (151133)

Mutation of four arginine residues in P34 leads to a decrease in binding between P34 and L5. by Anyango D. Kamina (4034165)

A Hierarchical Contact–Electrification Interface Based on Gradient Micro-/Nanostructured Hydrogel for Cardiovascular Disease Monitoring by Zhenqiu Gao (2564362)

“…Consequently, the gradient micro-/nanostructured hydrogel, fabricated via electric field induction, enables the sensor’s high-sensitivity region to reach 1.1–52.2 kPa, a 5-fold improvement over that of comparable sensors. …”

A Hierarchical Contact–Electrification Interface Based on Gradient Micro-/Nanostructured Hydrogel for Cardiovascular Disease Monitoring by Zhenqiu Gao (2564362)

“…Consequently, the gradient micro-/nanostructured hydrogel, fabricated via electric field induction, enables the sensor’s high-sensitivity region to reach 1.1–52.2 kPa, a 5-fold improvement over that of comparable sensors. …”

3-HPA and the 10-fold diluted reuterin-containing supernatant significantly decreased the <i>S.</i> Typhimurium χ3339 population. by Rosemarie De Weirdt (320666)

DOM assembly monitored with temperature and pH reveals that, as either pH decreases or temperature increases, microgel equilibrium size and assembly rates decrease at a non-linear... by Chi-Shuo Chen (234719)

Maternal Hypoxia Decreases Capillary Supply and Increases Metabolic Inefficiency Leading to Divergence in Myocardial Oxygen Supply and Demand by David Hauton (341981)

“…Hearts of male offspring subjected to Maternal Hypoxia showed a 20% decrease in cardiac output (<i>P</i><0.05), despite recording a 2-fold increase in glucose oxidation (<i>P</i><0.01) and 2.5-fold increase (<i>P</i><0.01) in palmitate oxidation. …”

IFN-β mRNA induction but IFN protein decrease in all mammalian cells upon ONNV infection. by Susanne E. Biesold (194461)

PI+ total immune cells are decreased at days 2, 5, and 14 following IR, and PI+ neutrophils are increased at day 30. by Jordan A. Gunning (18143970)

Subjects:

cDNA sequencing reveals missense point mutations in the UBA3 coding region of MLN4924-resistant K562 cells which decrease the sensitivity of NAE to MLN4924 in vitro. by G. Wei Xu (545673)

Fig 5 - by Mykola Pinkevych (125551)

Distribution of miRs with a greater than two fold-change. by Stephanie L. Samani (17896610)

Subjects: