Snapshotting the Excited-State Planarization of Chemically Locked <i>N</i>,<i>N</i>′‑Disubstituted Dihydrodibenzo[<i>a</i>,<i>c</i>]phenazines by Wei Chen (23863)

“…Accordingly, a series of <b>DPAC-<i>n</i></b> (<i>n</i> = 1–8) derivatives were synthesized, in which <i>n</i> correlates with the alkyl length, such that the strength of the spatial constraint decreases as <i>n</i> increases. …”

The effects of losartan on cytomegalovirus infection in human trabecular meshwork cells by Jin A. Choi (559035)

“…TM cells treated with TGF-β1 along with the presence of losartan for 48 hours showed marked decrease in the expression of α-smooth muscle actin (SMA), lysyl oxidase (LOX), connective tissue growth factor (CTGF), fibronectin and collagen-1A, compared with cells treated with TGF-β1 alone. …”

Polymorphisms in <i>CYP1B1</i>, <i>CYP3A5</i>, <i>GSTT1</i>, and <i>SULT1A1</i> Are Associated with Early Age Acute Leukemia by Bruno Almeida Lopes (740876)

“…Using data from the Brazilian Collaborative Study Group of Infant Acute Leukemia (2000–2012), 350 cases and 404 age-matched controls and 134 mothers of cases and controls were genotyped to explore polymorphisms in genes of the estrogen metabolism pathway: <i>CYP1B1</i> (c.1294C>G, rs1056836), <i>CYP3A4</i> (c.-392A>G, rs2740574), <i>CYP3A5</i> (c.219-237G>A, rs776746), <i>GSTM1/GSTT1</i> deletions, and <i>SULT1A1</i> (c.638G>A, rs9282861; and c.667A>G, rs1801030). …”

Assays of TUNEL revealed a decreased number of apoptotic cell after oroxylin A treatment. by Shu-Fang Lin (4167091)

Decreased activity of FASII favors the cold growth of the <i>ΔcshA</i> strain. by Vanessa Khemici (814639)

“…<i>fapR</i> mRNA levels were quantified by RT-qPCR using 16S rRNA as reference gene on total RNAs extracted from <i>wt</i> strain (PR01), <i>ΔcshA</i> strain (PR01-ΔcshA), and suppressor strains <i>ΔcshA/accC</i>^<i>M385V</i> (C51), <i>ΔcshA/accC</i>^<i>T183I</i> (sup30), <i>ΔcshA/accD</i>^<i>F253V</i> (sup17), <i>ΔcshA/accD</i>^<i>A164V</i> (sup16), <i>ΔcshA/birA</i>^{<i>D320F-FsX28</i>} (C58), <i>ΔcshA/birA</i>^{<i>R280stop</i>} (sup1) and <i>ΔcshA/bioY</i>^{<i>P123R-FsX1</i>} (C66), all at exponential growth phase in MH medium at 25°C. n = 5 for <i>ΔcshA</i>, <i>4 for wt</i> and 3 for all others. …”

Trial profile. by Chanel Avenant (409756)

“…Both contraceptives substantially decreased, from D0 to 25W, the total testosterone [DMPA-IM D0 0.560, 25W 0.423 nmol/L, -24.3% (p < 0.0001); NET-EN D0 0.551, 25W 0.253 nmol/L, -54.1%, (p < 0.0001)], SHBG [DMPA-IM D0 45.0, 25W 32.7 nmol/L, -29.8% (p < 0.0001); NET-EN D0 50.2, 25W 17.6 nmol/L, -65.1% (p < 0.0001)], and calculated free testosterone levels [DMPA-IM D0 6.87, 25W 5.38 pmol/L, -17.2% (p = 0.0371); NET-EN D0 6.00, 25W 3.70, -40.0% (p < 0.0001)]. …”

Compartment model of a myelinated axon. by Frank Rattay (127304)

Subjects:

Adverse events in low-dose naltrexone arm. by Judith I. Tsui (5983160)

“…Pain interference decreased for all three arms. Mean differences in change in pain interference for gabapentin vs. placebo, and naltrexone vs. placebo was 0.16 (95% CI -1.38, 1.71; p = 0.83) and 0.40 (95% CI -1.18, 1.99; p = 0.83), respectively.…”

CONSORT flow diagram. by Judith I. Tsui (5983160)

“…Pain interference decreased for all three arms. Mean differences in change in pain interference for gabapentin vs. placebo, and naltrexone vs. placebo was 0.16 (95% CI -1.38, 1.71; p = 0.83) and 0.40 (95% CI -1.18, 1.99; p = 0.83), respectively.…”

Adverse events in placebo arm. by Judith I. Tsui (5983160)

“…Pain interference decreased for all three arms. Mean differences in change in pain interference for gabapentin vs. placebo, and naltrexone vs. placebo was 0.16 (95% CI -1.38, 1.71; p = 0.83) and 0.40 (95% CI -1.18, 1.99; p = 0.83), respectively.…”

Adverse events in gabapentin arm. by Judith I. Tsui (5983160)

“…Pain interference decreased for all three arms. Mean differences in change in pain interference for gabapentin vs. placebo, and naltrexone vs. placebo was 0.16 (95% CI -1.38, 1.71; p = 0.83) and 0.40 (95% CI -1.18, 1.99; p = 0.83), respectively.…”

The raw data for Fig 5B. by Hongjoo An (21703199)

“…Consistently, <i>Pick1</i>, a gene that is near the <i>Sox10</i> TAD border, is also under the transcriptional control of Sox10-E1 and Sox10-E2. …”

Identifying Loci Contributing to Natural Variation in Xenobiotic Resistance in <i>Drosophila</i> by Michael A. Najarro (831657)

“…<i>Cyp12d1</i> is implicated by QTL mapped in both panels of DSPR RILs, is significantly upregulated in the presence of caffeine, and RNAi knockdown robustly decreases caffeine tolerance. …”

Decrease in 8-OHdG with age in a mixed-longitudinal sample (n = 36 individuals, 583 samples). by Nicole Thompson González (9257300)

Expression of vTR harboring the mutant template (AU5) decreases cell proliferation of an avian cancer cell line. by Benedikt B. Kaufer (341018)

Decreased weight loss in FI-A2 and G-A2 peptide vaccinated mice after RSV challenge. by Gertrud U. Rey (501694)

SDG decreases p70S6K1 and increases AMPK protein expression in iron treated H9c2 cells. by Stephanie Puukila (568109)

Juvenile demyelination induces a loss of functional autapses. by Sara Hijazi (21656615)

“…<p><b>A</b>. <i>Upper panel</i>. Example traces (average of 8 sweeps) of unitary autaptic inhibitory postsynaptic currents triggered by voltage steps from holding potential of -−70 mV to 0 mV in PV interneuron (fast inward Na+ currents were partially removed), which can be blocked by gabazine (gray). …”

PSD-95 decreased ASIC2a acid-evoked current. by Anne Marie S. Harding (546425)

AA-deficient <i>sfx</i> mice had decreased articular cartilage. by Richard C. Lindsey (7148168)