Image4_Analysis of Geometric and Hemodynamic Profiles in Rat Arteriovenous Fistula Following PDE5A Inhibition.tif by Hannah Northrup (5938436)

“…In both groups: 1) CSA increased from the 0–5 to 15–20 zone; 2) velocity, WSS, and vorticity were highest in the 0–5 zone and dropped significantly thereafter; and 3) OSI increased at the 5–10 zone and then decreased gradually. …”

Development of an Acrylate Derivative Targeting the NLRP3 Inflammasome for the Treatment of Inflammatory Bowel Disease by Mattia Cocco (1697905)

“…The in vitro determination of reactivity, cytotoxicity, NLRP3 ATPase inhibition, and antipyroptotic properties allowed the selection of <b>11</b> (INF39), a nontoxic, irreversible NLRP3 inhibitor able to decrease interleukin-1β release from macrophages. Bioluminescence resonance energy transfer experiments proved that this compound was able to directly interfere with NLRP3 activation in cells. …”

Discovery of Novel Oxazepine Derivatives as Akt/ROCK Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment by Jinxin Che (791250)

“…Treatment with <b>B12</b> results in the arrest of G0/G1 cell cycles, a significant decrease in N-myc protein level, and an increase in differentiation markers. …”

Discovery of Novel Oxazepine Derivatives as Akt/ROCK Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment by Jinxin Che (791250)

“…Treatment with <b>B12</b> results in the arrest of G0/G1 cell cycles, a significant decrease in N-myc protein level, and an increase in differentiation markers. …”

Discovery of Novel Oxazepine Derivatives as Akt/ROCK Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment by Jinxin Che (791250)

“…Treatment with <b>B12</b> results in the arrest of G0/G1 cell cycles, a significant decrease in N-myc protein level, and an increase in differentiation markers. …”

Discovery of Novel Oxazepine Derivatives as Akt/ROCK Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment by Jinxin Che (791250)

“…Treatment with <b>B12</b> results in the arrest of G0/G1 cell cycles, a significant decrease in N-myc protein level, and an increase in differentiation markers. …”

Image_5_The Design, Characterizations, and Tumor Angiogenesis Inhibition of a Multi-Epitope Peptibody With bFGF/VEGFA.TIF by Ligang Zhang (830488)

“…Immunization with Peptibody could elicit high-titer anti-bFGF and anti-VEGFA antibodies, activate T cells, and induce Th1/Th2-type cytokines. In in vitro experiments, the isolated anti-Peptibody antibody inhibited the proliferation and migration of A549 cells and human umbilical vein endothelial cells (HUVECs) by decreasing the MAPK/Akt/mTOR signal pathways. …”

Image_5_The Design, Characterizations, and Tumor Angiogenesis Inhibition of a Multi-Epitope Peptibody With bFGF/VEGFA.TIF by Ligang Zhang (830488)

“…Immunization with Peptibody could elicit high-titer anti-bFGF and anti-VEGFA antibodies, activate T cells, and induce Th1/Th2-type cytokines. In in vitro experiments, the isolated anti-Peptibody antibody inhibited the proliferation and migration of A549 cells and human umbilical vein endothelial cells (HUVECs) by decreasing the MAPK/Akt/mTOR signal pathways. …”

Table5_MicroRNA-21 and microRNA-148a affects PTEN, NO and ROS in canine leishmaniasis.DOCX by Jéssica Henrique De Freitas (15215455)

“…PTEN levels increased, NO and ROS decreased in SLs from dogs with CanL. Inhibition of miRNA-21 resulted in PTEN increase; in contrast, PTEN decreased after miR-148a inhibition. …”

Image_5_MoMih1 is indispensable for asexual development, cell wall integrity, and pathogenicity of Magnaporthe oryzae.tif by Shiyi Liu (1702921)

“…We here functionally characterized the Mih1 homologue MoMih1 in M. oryzae. …”

PowerPoint Slides for: Pharmacodynamic Effects of Sucroferric Oxyhydroxide and Sevelamer Carbonate on Vitamin D Receptor Agonist Bioactivity in Dialysis Patients by Sprague S.M. (2884187)

Quality evaluation of incorporated literature. by Rongrong Han (9258298)

“…</p><p>Results</p><p>Twenty-one RCTs were included in this Meta-analysis. The Meta-analysis indicated that early tracheotomy could significantly shorten the duration of mechanical ventilation (MD: -2.77; 95% CI -5.10~ -0.44; <i>P</i> = 0.02) and the length of ICU stay (MD: -6.36; 95% CI -9.84~ -2.88; <i>P</i> = 0.0003), but it did not significantly alter the all-cause mortality (RR 0.86; 95% CI 0.73~1.00; <i>P</i> = 0.06), the incidence of pneumonia (RR 0.86; 95% CI 0.74~1.01; <i>P</i> = 0.06), and length of hospital stay (MD: -3.24; 95% CI -7.99~ 1.52; <i>P</i> = 0.18).…”

Publish bias funnel plots of pneumonia. by Rongrong Han (9258298)

“…</p><p>Results</p><p>Twenty-one RCTs were included in this Meta-analysis. The Meta-analysis indicated that early tracheotomy could significantly shorten the duration of mechanical ventilation (MD: -2.77; 95% CI -5.10~ -0.44; <i>P</i> = 0.02) and the length of ICU stay (MD: -6.36; 95% CI -9.84~ -2.88; <i>P</i> = 0.0003), but it did not significantly alter the all-cause mortality (RR 0.86; 95% CI 0.73~1.00; <i>P</i> = 0.06), the incidence of pneumonia (RR 0.86; 95% CI 0.74~1.01; <i>P</i> = 0.06), and length of hospital stay (MD: -3.24; 95% CI -7.99~ 1.52; <i>P</i> = 0.18).…”

Subgroup analyses for incidence of pneumonia. by Rongrong Han (9258298)

“…</p><p>Results</p><p>Twenty-one RCTs were included in this Meta-analysis. The Meta-analysis indicated that early tracheotomy could significantly shorten the duration of mechanical ventilation (MD: -2.77; 95% CI -5.10~ -0.44; <i>P</i> = 0.02) and the length of ICU stay (MD: -6.36; 95% CI -9.84~ -2.88; <i>P</i> = 0.0003), but it did not significantly alter the all-cause mortality (RR 0.86; 95% CI 0.73~1.00; <i>P</i> = 0.06), the incidence of pneumonia (RR 0.86; 95% CI 0.74~1.01; <i>P</i> = 0.06), and length of hospital stay (MD: -3.24; 95% CI -7.99~ 1.52; <i>P</i> = 0.18).…”

Publish bias funnel plots of mortality. by Rongrong Han (9258298)

“…</p><p>Results</p><p>Twenty-one RCTs were included in this Meta-analysis. The Meta-analysis indicated that early tracheotomy could significantly shorten the duration of mechanical ventilation (MD: -2.77; 95% CI -5.10~ -0.44; <i>P</i> = 0.02) and the length of ICU stay (MD: -6.36; 95% CI -9.84~ -2.88; <i>P</i> = 0.0003), but it did not significantly alter the all-cause mortality (RR 0.86; 95% CI 0.73~1.00; <i>P</i> = 0.06), the incidence of pneumonia (RR 0.86; 95% CI 0.74~1.01; <i>P</i> = 0.06), and length of hospital stay (MD: -3.24; 95% CI -7.99~ 1.52; <i>P</i> = 0.18).…”

Study inclusion flowchart. by Rongrong Han (9258298)

“…</p><p>Results</p><p>Twenty-one RCTs were included in this Meta-analysis. The Meta-analysis indicated that early tracheotomy could significantly shorten the duration of mechanical ventilation (MD: -2.77; 95% CI -5.10~ -0.44; <i>P</i> = 0.02) and the length of ICU stay (MD: -6.36; 95% CI -9.84~ -2.88; <i>P</i> = 0.0003), but it did not significantly alter the all-cause mortality (RR 0.86; 95% CI 0.73~1.00; <i>P</i> = 0.06), the incidence of pneumonia (RR 0.86; 95% CI 0.74~1.01; <i>P</i> = 0.06), and length of hospital stay (MD: -3.24; 95% CI -7.99~ 1.52; <i>P</i> = 0.18).…”

Table_5_The Protective Effect of the Soluble Egg Antigen of Schistosoma japonicum in A Mouse Skin Transplantation Model.xls by Jie Jiang (187037)

Effects of age of acquisition and category size on signed verbal fluency by Onur Keleş (12329863)

Induction of autophagy through CLEC4E in combination with TLR4: an innovative strategy to restrict the survival of <i>Mycobacterium tuberculosis</i> by Susanta Pahari (37943)

“…</p> <p>3MA: 3 methyladenine; AO: acridine orange; Atg5: autophagy related 5; AVOs: acidic vesicular organelles; BECN1: beclin 1, autophagy related; BMDMs: bone marrow derived macrophages; bw: body weight; C₄.T₄: agonists of CLEC4E (C₄/TDB) and TLR4 (T₄/ultra-pure-LPS); CFU: colony forming unit; CLEC4E/Mincle: C-type lectin domain family 4, member e; CLR: c-type lectin receptor; INH: isoniazid; LAMP1: lysosomal-associated membrane protein 1; Mφ^C4.T4: <i>Mtb-</i>infected C₄.T₄ stimulated macrophages; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MDC: monodansylcadaverine; MTOR: mechanistic target of rapamycin kinase; MYD88: myeloid differentiation primary response 88; NFKB: nuclear factor of kappa light polypeptide gene enhance in B cells; NLR: NOD (nucleotide-binding oligomerization domain)-like receptors; PFA: paraformaldehyde; PPD: purified protein derivative; PtdIns3K: class III phosphatidylinositol 3-kinase; RELA: v-rel reticuloendotheliosis viral oncogene homolog A (avian); RIF: rifampicin; RLR: retinoic acid-inducible gene-I-like receptors; TDB: trehalose-6,6´-dibehenate; TLR4: toll-like receptor 4; Ultra-pure-LPS: ultra-pure lipopolysaccharide-EK; V-ATPase: vacuolar-type H⁺ ATPase.…”

TMG-123, a novel glucokinase activator, exerts durable effects on hyperglycemia without increasing triglyceride in diabetic animal models by Yoshinori Tsumura (3753757)

“…However, clinical development of GK activators has failed due to the loss of glucose-lowering effects and increased plasma triglyceride levels after chronic treatment. Here, we generated a novel GK activator, TMG-123, examined its <i>in vitro</i> and <i>in vivo</i> pharmacological characteristics, and evaluated its risks of aforementioned clinical issues. …”