DataSheet1_v1_Rejuveinix Shows a Favorable Clinical Safety Profile in Human Subjects and Exhibits Potent Preclinical Protective Activity in the Lipopolysaccharide-Galactosamine Mou... by Fatih M. Uckun (447782)

“…RJX is being developed as an anti-inflammatory and anti-oxidant treatment platform for patients with sepsis, including COVID-19 patients with viral sepsis and ARDS. Here, we report its clinical safety profile in a phase 1 clinical study (ClinicalTrials.gov Identifier: NCT03680105) and its potent protective activity in the lipopolysaccharide galactosamine (LPS-GalN) mouse model of ARDS.…”

Image_1_Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage.JPEG by Tongtong Wang (775312)

“…As a result, APα-induced an increase in the number of TH-positive SH-SY5Y cells might be mediated through GABAAR via Ca²⁺/CaM/CaMKIIδ3/BDNF (CDK1) signaling pathway, which would ultimately facilitate to elucidate PD pathogenesis and hold a promise as an alternative therapeutic target for PD.…”

Image_1_Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage.JPEG by Tongtong Wang (775312)

“…As a result, APα-induced an increase in the number of TH-positive SH-SY5Y cells might be mediated through GABAAR via Ca²⁺/CaM/CaMKIIδ3/BDNF (CDK1) signaling pathway, which would ultimately facilitate to elucidate PD pathogenesis and hold a promise as an alternative therapeutic target for PD.…”

Image_2_Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage.JPEG by Tongtong Wang (775312)

“…As a result, APα-induced an increase in the number of TH-positive SH-SY5Y cells might be mediated through GABAAR via Ca²⁺/CaM/CaMKIIδ3/BDNF (CDK1) signaling pathway, which would ultimately facilitate to elucidate PD pathogenesis and hold a promise as an alternative therapeutic target for PD.…”

Image_2_Allopregnanolone Modulates GABAAR-Dependent CaMKIIδ3 and BDNF to Protect SH-SY5Y Cells Against 6-OHDA-Induced Damage.JPEG by Tongtong Wang (775312)

“…As a result, APα-induced an increase in the number of TH-positive SH-SY5Y cells might be mediated through GABAAR via Ca²⁺/CaM/CaMKIIδ3/BDNF (CDK1) signaling pathway, which would ultimately facilitate to elucidate PD pathogenesis and hold a promise as an alternative therapeutic target for PD.…”

Polyfunctionality of <i>T</i>. <i>cruzi</i>-specific CD4⁺ T cells in patients with chronic Chagas disease with no sign of cardiomyopathy is improved after <i>in vitro</i... by María Ailén Natale (6843422)

Альтернативный взгляд на этимологию «Руси», «реки» и связанных понятий: Когнитивно-образный подход / An Alternative Perspective on the Etymology of «Rus’», «Reka» (River), and Rela... by Aleksey Pogrebnoj-Alexandroff (21491708)

Influence of Agropastoral System Components on Mountain Grassland Vulnerability Estimated by Connectivity Loss by Maite Gartzia (669601)

“…We estimated the vulnerability of dense grasslands in the Central Pyrenees, Spain, based on the connectivity loss (CL) among grassland patches that has occurred between the 1980s and the 2000s, as a result of i) an increase in biomass and greenness (CL-IBG), ii) woody encroachment (CL-WE), or iii) a decrease in biomass and greenness (CL-DBG). …”

Gametocyte numbers can increase (A) or decrease (B, C) even when transmission investment is constant over the time period observed. by Megan A. Greischar (2150737)

“…<p>For clarity, we assume that replication and gametocyte development both require one day and 50% of new gametocytes persist for an additional day (“Old gametocytes”). …”

Time course of the SARS-CoV-2 pandemic up to 7 November 2020 for the seven regions in England in the constant IFR model. by Siyu Chen (278663)

Image_1_A Mutation in VWA1, Encoding von Willebrand Factor A Domain-Containing Protein 1, Is Associated With Hemifacial Microsomia.TIF by Yibei Wang (5321825)

“…</p>Results<p>Through WES and a set of filtration, we identified a c.G905A:p.R302Q point mutation in a novel candidate pathogenic gene, VWA1. …”

Table_1_A Mutation in VWA1, Encoding von Willebrand Factor A Domain-Containing Protein 1, Is Associated With Hemifacial Microsomia.DOCX by Yibei Wang (5321825)

“…</p>Results<p>Through WES and a set of filtration, we identified a c.G905A:p.R302Q point mutation in a novel candidate pathogenic gene, VWA1. …”

A simplified scheme of 5α/β-reduced C19 steroid biosynthesis in human, “backdoor pathway”. by Antonín Pařízek (3142470)

A simplified scheme of 5α/β-reduced C19 steroid biosynthesis in the human “frontdoor pathway”. by Antonín Pařízek (3142470)

Changes in central metabolism in <i>V. cholerae</i> Δ<i>nqrA-F</i> mutant. by Yusuke Minato (263245)

Sodium butyrate alleviates potential Alzheimer’s disease in vitro by suppressing Aβ and tau activation and ameliorates Aβ-induced toxicity by Al Borhan Bayazid (16711360)

“…Sodium butyrate (NaB) is an HDAC inhibitor profoundly found to be neuroprotective. We have investigated the neuroprotective effects of NaB in SH-SY5Y cells stimulated with TNF-α/Aβ in SH-SY5Y cells and LPS-induced BV-2 cells. …”

ReaxFF Reactive Force Field for Exploring Electronically Switchable Polarization in Zn_1–<i>x</i>Mg_<i>x</i>O Ferroelectric Semiconductors by Alireza Sepehrinezhad (19199048)

“…Our analysis indicates that an increase in Mg-substitution correlates with a decrease in the coercive field. We also observe a strong temperature dependence of the coercive field in Zn_1–<i>x</i>Mg_<i>x</i>O, with values decreasing as the temperature increases. …”

Cold-fractured cross sections of Sample 4 (A), Sample 5 (B), Sample 6 (C) (see by Kyungwho Choi (300480)

Data_Sheet_1_Expression and Functional Analysis of lncRNAs Involved in Platelet-Derived Growth Factor-BB-Induced Proliferation of Human Aortic Smooth Muscle Cells.PDF by Jia-Jie Lin (11398619)

“…HIF1A-AS2 suppression decreased HASMC proliferation via the miR-30e-5p/CCND2 mRNA axis. …”

Table_1_Expression and Functional Analysis of lncRNAs Involved in Platelet-Derived Growth Factor-BB-Induced Proliferation of Human Aortic Smooth Muscle Cells.XLS by Jia-Jie Lin (11398619)

“…HIF1A-AS2 suppression decreased HASMC proliferation via the miR-30e-5p/CCND2 mRNA axis. …”