Dynamic Magnetic Fields Remote-Control Apoptosis <i>via</i> Nanoparticle Rotation by Enming Zhang (416565)

“…To this end, we covalently conjugated SPIONs with antibodies targeting the lysosomal protein marker LAMP1 (LAMP1-SPION). …”

Dynamic Magnetic Fields Remote-Control Apoptosis <i>via</i> Nanoparticle Rotation by Enming Zhang (416565)

“…To this end, we covalently conjugated SPIONs with antibodies targeting the lysosomal protein marker LAMP1 (LAMP1-SPION). …”

Dynamic Magnetic Fields Remote-Control Apoptosis <i>via</i> Nanoparticle Rotation by Enming Zhang (416565)

“…To this end, we covalently conjugated SPIONs with antibodies targeting the lysosomal protein marker LAMP1 (LAMP1-SPION). …”

Image_1_FRET-Based Detection and Quantification of HIV-1 Virion Maturation.TIF by Anamaria D. Sarca (6715562)

“…We inserted an optimized intramolecular CFP-YPF FRET donor-acceptor pair bridged with an HIV-1 protease cleavage sequence between the Gag MA-CA domains. …”

Table_1_FRET-Based Detection and Quantification of HIV-1 Virion Maturation.docx by Anamaria D. Sarca (6715562)

“…We inserted an optimized intramolecular CFP-YPF FRET donor-acceptor pair bridged with an HIV-1 protease cleavage sequence between the Gag MA-CA domains. …”

BK channel activity in skin fibroblasts from patients with neurological disorder by Ria L. Dinsdale (10519767)

“…<p>Seventy-five unique variants in the <i>KCNMA1</i> gene have been identified from individuals with neurological disorders. …”

Sensitivity of the long-term reduction in microfilarial load in individuals under 20 years of age to the assumed rate of decay of vaccine efficacy. by Hugo C. Turner (407442)

“…<p>The mean duration of vaccine prophylactic (against incoming L3 larvae) and therapeutic (against microfilariae) activity is 1/the rate of decay (i.e. 5, 10, 20 and 50 years). …”

Clinical Determinants of HIV-1B Between-Host Evolution and their Association with Drug Resistance in Pediatric Patients by Israel Pagán (52437)

“…To address these questions, HIV-1 subtype B (HIV-1B) <i>pol</i> sequences of 163 infected children and 450 adults of Madrid, Spain, were used to estimate genetic diversity, rates of synonymous and non-synonymous mutations, selection pressures and frequency of drug-resistance mutations (DRMs). …”

Effectiveness of a serious game for medical education on insulin therapy: a pilot study by Leandro A. Diehl (6144782)

“…<div><p>Objective We report the preliminary assessment of InsuOnline©, a serious game designed for medical education on insulin therapy.Materials and methods We conducted a pilot study with 41 undergraduate medical students and Internal Medicine residents to assess the educational effectiveness of InsuOnline©, as compared to a traditional educational activity (lecture, cases discussion). …”

Image_1_GPCR19 Regulates P2X7R-Mediated NLRP3 Inflammasomal Activation of Microglia by Amyloid β in a Mouse Model of Alzheimer’s Disease.tif by Jahirul Islam (11280516)

“…Due to polymorphisms, subtypes, and ubiquitous expression of P2X7R, inhibition of P2X7R has not been effective for AD. We first report that taurodeoxycholate (TDCA), a GPCR19 ligand, inhibited the priming phase of N3I activation, suppressed P2X7R expression and P2X7R-mediated Ca⁺⁺ mobilization and N3I oligomerization, which is essential for production of IL-1β/IL-18 by microglia. …”

Identification of the Transcription Factor Znc1p, which Regulates the Yeast-to-Hypha Transition in the Dimorphic Yeast <i>Yarrowia lipolytica</i> by Azul Martinez-Vazquez (426022)

“…Here, we report the isolation and characterization of a gene, <i>ZNC1</i>, involved in the dimorphic transition in <i>Y. lipolytica</i>. …”

Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2. by P, Sneha

“…Molecular docking analysis revealed a decrease in interaction between the protein and ATP in all the 3 mutations, and molecular dynamic simulations of 50 ns showed a loss of stability and compactness in the mutant proteins. …”
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image_1.pdf by Catalina Burbano (4900783)

“…These vesicles derived from platelets (PMPs), mainly PMPs-IgG +, activated monocytes in vitro and increased the expression of CD69, CD64, and pro-inflammatory cytokines such as IL-1β, TNF-α, and IFN-α. Therefore, MPs are one of the most representative sources of the total amount of circulating ICs-IgG + in patients with SLE. …”

S1 Raw images - by Arndt Schnuchel (16378677)

“…However, concerns over the quality and efficacy of these products were raised due to less stringent regulatory requirements. In the present study, we compared a recombinant <i>E</i>. <i>coli</i>-derived ASNase marketed in Europe (Spectrila^®) with an <i>E</i>. …”

Abnormal CO₂ and H₂O Diffusion in CALF-20(Zn) Metal–Organic Framework: Fundamental Understanding of CO₂ Capture by Yann Magnin (3997151)

“…Interestingly, the diffusion coefficients of CO₂ and H₂O were also found to be of the same order of magnitude, with similar nonlinear profiles as a function of the guest loading. We further demonstrated that the diffusion coefficient for CO₂ in the presence of water decreases with increasing water loading.…”

Design and Synthesis of 1,2-Bis(hydroxymethyl)pyrrolo[2,1‑<i>a</i>]phthalazine Hybrids as Potent Anticancer Agents that Inhibit Angiogenesis and Induce DNA Interstrand Cross-links... by Sue-Ming Chang (6411923)

“…Hybrid molecules are composed of two pharmacophores with different biological activities. Here, we conjugated phthalazine moieties (antiangiogenetic pharmacophore) and bis­(hydroxymethyl)­pyrrole moieties (DNA cross-linking agent) to form a series of bis­(hydroxymethyl)­pyrrolo­[2,1-<i>a</i>]­phthalazine hybrids. …”

Table_1_HIV-1 and opiates modulate miRNA profiles in extracellular vesicles.docx by Allen Caobi (8858777)

“…SH-SY5Y cells, treated with xEVs derived from ART-treated PBMCs, exhibited increased viability while for SH-SY5Ys exposed to xEVs derived from HIV-1 infected PBMCs viability was decreased compared to the untreated control. …”

Data_Sheet_1_Ototoxicity of polystyrene nanoplastics in mice, HEI-OC1 cells and zebrafish.DOCX by Yuancheng Wu (12012329)

“…Furthermore, we observed that the expression of ferroptosis-related indicators GPX4 and SLC7A11 decreased as well as increased expression of ACLS4 in cochlea and HEI-OC1 cells. …”

Regulation of STUB1 expression and its biological significance in mouse Sertoli cells by Tao Li (86810)

“…On the latter, a homozygous mutation in the <i>STUB1</i> gene has been identified in patients with hypogonadism. …”

Loss of BAP1 expression is associated with genetic mutation and can predict outcomes in gallbladder cancer by Takashi Hirosawa (5931845)

“…We carried out genomic, epigenomic and immunohistochemical analyses to detect somatic <i>BAP1</i> alterations in 47 GBC patients undergoing surgical resection.…”