In silico screening, molecular docking, and molecular dynamics studies of SNP-derived human P5CR mutants by Peng Sang (611847)

“…<p>Pyrroline-5-carboxylate reductase (P5CR) encoded by <i>PYCR1</i> gene is a housekeeping enzyme that catalyzes the reduction of P5C to proline using NAD(P)H as the cofactor. …”

Modeling of the BXA-rPA_N binding interface of A(H1N1)pdm09 with E23G/K. by Jeremy C. Jones (9248188)

Table_1_MicroRNA-138-5p Suppresses Non-small Cell Lung Cancer Cells by Targeting PD-L1/PD-1 to Regulate Tumor Microenvironment.pdf by Nannan Song (5491205)

“…The regulatory mechanism of miR-138 in NSCLC remains not very clear. Herein, we demonstrated that miR-138-5p treatment decreased the growth of tumor cells and increased the number of tumor-infiltrated DCs. miR-138-5p not only down-regulated the expression of cyclin D3 (CCND3), CCD20, Ki67, and MCM in A549/3LL cells, but also regulated the maturation of DCs in A549-bearing nude mice and the 3LL-bearing C57BL/6 mouse model, and DCs’ capability to enhance T cells to kill tumor cells. …”

Image_1_MicroRNA-138-5p Suppresses Non-small Cell Lung Cancer Cells by Targeting PD-L1/PD-1 to Regulate Tumor Microenvironment.pdf by Nannan Song (5491205)

“…The regulatory mechanism of miR-138 in NSCLC remains not very clear. Herein, we demonstrated that miR-138-5p treatment decreased the growth of tumor cells and increased the number of tumor-infiltrated DCs. miR-138-5p not only down-regulated the expression of cyclin D3 (CCND3), CCD20, Ki67, and MCM in A549/3LL cells, but also regulated the maturation of DCs in A549-bearing nude mice and the 3LL-bearing C57BL/6 mouse model, and DCs’ capability to enhance T cells to kill tumor cells. …”

Image_1_MicroRNA-138-5p Suppresses Non-small Cell Lung Cancer Cells by Targeting PD-L1/PD-1 to Regulate Tumor Microenvironment.pdf by Nannan Song (5491205)

“…The regulatory mechanism of miR-138 in NSCLC remains not very clear. Herein, we demonstrated that miR-138-5p treatment decreased the growth of tumor cells and increased the number of tumor-infiltrated DCs. miR-138-5p not only down-regulated the expression of cyclin D3 (CCND3), CCD20, Ki67, and MCM in A549/3LL cells, but also regulated the maturation of DCs in A549-bearing nude mice and the 3LL-bearing C57BL/6 mouse model, and DCs’ capability to enhance T cells to kill tumor cells. …”

Table_1_MicroRNA-138-5p Suppresses Non-small Cell Lung Cancer Cells by Targeting PD-L1/PD-1 to Regulate Tumor Microenvironment.pdf by Nannan Song (5491205)

“…The regulatory mechanism of miR-138 in NSCLC remains not very clear. Herein, we demonstrated that miR-138-5p treatment decreased the growth of tumor cells and increased the number of tumor-infiltrated DCs. miR-138-5p not only down-regulated the expression of cyclin D3 (CCND3), CCD20, Ki67, and MCM in A549/3LL cells, but also regulated the maturation of DCs in A549-bearing nude mice and the 3LL-bearing C57BL/6 mouse model, and DCs’ capability to enhance T cells to kill tumor cells. …”

Table1_Characterization of the chicken melanocortin 5 receptor and its potential role in regulating hepatic glucolipid metabolism.DOCX by Xiao Zhang (152326)

“…We demonstrated that MRAP2 decreased MC5R sensitivity to α-MSH, whereas MRAP1 did not have a similar effect, and that both MRAPs significantly reduced MC5R expression on the cell membrane surface. …”

Numbers of new neurons in Area X as a function of hemisphere and experimental condition. by Jake V. Aronowitz (11361921)

The decrease in <i>Brucella</i> AHLs activity during <i>in vitro</i> growth is linked to <i>aibP</i> expression. by Matthieu Terwagne (495790)

MG-suppressed cell proliferation in a xenotransplantation model. by Chien-Yu Huang (802982)

“…Fluorescence labeled Hep3B and HepJ5 cells were implanted into an embryo yolk of the zebrafish, and then embryos were exposed to 40 μg/ml MG or dH₂O as a vehicle control. …”

MiR-425 and miR-155 produced an additive decrease in cGMP levels relative to either miRNA alone. by Sara Vandenwijngaert (390970)

MCs^α2 contribute to FDDI, and MC^α2 burst firing can reset type A PC spikes. by Markus M. Hilscher (473981)

SUS score for Task 1. by Mucahit Gemici (21519313)

Protective effect of phosphoenolpyruvate carboxykinase 1 on inflammation and fibrotic progression of IgA nephropathy by Ya-yin Tan (21448519)

“…In experiments with SV40-transformed mouse glomerular mesangial cells (MCs), PCK1 and PPARγ protein expression levels were significantly decreased in polymeric IgA1 (pIgA1)-stimulated MCs, which contrasts with the increased expression of inflammatory and fibrotic factors. …”

Oral infection with YFV-Asibi cap0 leads to lower viral loads in the midguts largely diminishing dissemination to secondary tissues. by Anja vom Hemdt (19787189)

Table_5_Trichohyalin gene expression is negatively correlated with the severity of dermatitis in a canine atopic dermatitis model.XLSX by Rosanna Marsella (8606172)

“…The effects of chronic exposure to HDM on the skin have not been studied in this animal model, and it is not known how changes in gene expression correlate to the severity of dermatitis.</p>Methods<p>We used an established canine model of AD and took biopsies before HDM exposure (D0) and five times during repeated allergen challenges (on Days 1, 2, 8, 15, and 29, hereafter referred to as D1, D2, D8, D15, and D29). …”

Opinion distributions and mean shadow ban strength versus time under shadow banning control policies for different objective functions on a path network. by Yen-Shao Chen (18264587)

Computational model of WDR neuron with ASIC1a channel parameters and a synaptic cleft acidification system. by Magda Chafaï (15307098)

“…<b><i>E</i></b>, Simulation windup curves obtained without (control, no ASIC, black dots) and with moderate heteromeric ASIC1a conductances <i><u>g</u></i> is 0.4nS, 0.8nS, 1.5nS and 3nS, green squares). …”

Supplementary Material for: Can the Mixed Virtual Reality Simulator Into D’mentia Enhance Empathy and Understanding and Decrease Burden in Informal Dementia Caregivers? by Jütten L.H. (6056222)

“…<b><i>Objective:</i></b> To evaluate whether the mixed virtual reality dementia simulator training Into D’mentia increased informal caregivers’ understanding for people with dementia, their empathy, sense of competence, relationship quality with the care receiver, and/or decreased burden, depression, and anxiety. <b><i>Methods:</i></b> A quasi-experimental longitudinal study with an intervention group (<i>n</i> = 145) and a control group (<i>n</i> = 56) was conducted. …”

Decreasing HIV transmissions to African American women through interventions for men living with HIV post-incarceration: An agent-based modeling study by Joëlla W. Adams (2192254)

“…Interventions optimizing HIV care engagement and minimizing sexual risk behaviors for men living with HIV post-incarceration may decrease HIV incidence.</p><p>Methods</p><p>Using an agent-based model, we simulated a sexual and injection drug using network representing the African American population of Philadelphia. …”