Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

“…Here, we reported our medicinal chemistry efforts that led to the discovery of the triazolo­[1,5-<i>a</i>]­pyrimidine derivative <b>WS-898</b> as a highly effective ABCB1 inhibitor capable of reversing paclitaxel (PTX) resistance in drug-resistant SW620/Ad300, KB-C2, and HEK293/ABCB1 cells (IC₅₀ = 5.0, 3.67, and 3.68 nM, respectively), more potent than verapamil and zosuquidar. …”

CD107a-, IFNγ- and MIP 1β-producing Vγ9Vδ2 T-cell subsets decrease in HIV+ patients. by Rita Casetti (608635)

An example of three consecutive accretive growth steps. by Nol Chindapol (103374)

Table_1_Unconventional Sea Surface Temperature Regime Around Japan in the 2000s–2010s: Potential Influences on Major Fisheries Resources.docx by Hiroshi Kuroda (769431)

“…In this paper, we review atmosphere and ocean conditions around Japan in the 2000s–2010s in terms of global climate, present an overview of potential impacts of decadal SST trends on five major commercial fisheries resources (walleye pollock, chum salmon, Japanese sardine, Japanese anchovy, and Japanese flying squid), and raise awareness that an unconventional regime can appear transiently during a state of global warming.…”

Decrease of SMAD3 protein, but not SMAD2 in DBA iPSCs. by Jingping Ge (636557)

“…The nuclear p-SMAD2 decreased in <i>RPL5</i> mutant and corrected lines. …”

5-year risk of cardiovascular diseases under exposure deciles of A) HbA1C-CV and B) FPG-CV. by Khadije Maajani (10125692)

Influence of stabilized MetA protein on the <i>E.coli</i> WE strain growth under stressful conditions. by Elena A. Mordukhova (646403)

Different steps of the fabrication process. by Md. Abu Daud (21485629)

Foxo1 decreases <i>SCN5a</i> promoter activity. by Weike Mao (181121)

Nicotine decreased Wnt5a expressions in SK-BR-3 cells. by Masanori A. Murayama (5774585)

Transmission electron micrographs of step 5 spermatids. by Yonggang Lu (358237)

“…<p><b>(A)</b> As the nuclear size (N) of step 5 spermatids decreases, the decondensed chromosomes are aggregated into a retiform pattern. …”

The methodological figure of the experimental steps. by Railson de Oliveira Ferreira (6493700)

A decrease in circulating CXCR5+CD4+ Tfh cells is associated with HCC progression, and CXCR5+CD4+ Tfh cells are decreased in tumor regions. by Yiqiong Jia (692871)

“…<p>(A) The prevalence of CXCR5+CD4+ Tfh cells decreases with progressive stages in HCC. …”

Decreasing the use of edible oils in China using WeChat and theories of behavior change: study protocol for a randomized controlled trial. by Zhu, Rui

“…Described by Forbes as one of the world's most powerful apps, WeChat provides considerable convenience in disseminating knowledge. …”
Get full text
Get full text

Increased expression of Fz5 receptor matched with a decrease in NeuN immunoreactivity at 16w. by Carlos González-Fernández (2794207)

MeV disrupted mitochondrial network and cellular metabolism. by Pierre Khalfi (7868252)

Subjects:

<i>Zip88E</i>^<i>Δ/Δ</i> larvae have decreased <i>MtnB</i>:<i>EYFP</i> expression. by Christopher D. Richards (4246669)

“…<p>A, B, D, E) <i>MtnB</i>:<i>EYFP</i> expression in third instar larval midguts from control and <i>Zip88E</i>^<i>Δ/Δ</i> homozygous larvae on basal medium (A and B) and after exposure to 2 mmol l^-1 ZnCl₂-supplemented medium (D, E). …”

The synchronous activity of SGN fiber populations is disrupted and their response to sound is decreased with increasing levels of <i>L</i>_<i>u</i> heterogeneity. by Maral Budak (6680351)

Supplementary Material for: SGLT2 inhibitors decrease overhydration and proteasuria in patients with chronic kidney disease: a longitudinal observational study by Schork A. (17795387)

“…At baseline, patients displayed overhydration (OH) with + 0.4 (-0.2 – 2.2) L/1.73m² which decreased by 0.5 (0.1 – 1.2) L/1.73m² after 6 months. …”