RNA Splicing Is Responsive to MBNL1 Dose by Sonali P. Jog (119574)

“…Here we demonstrate that a gradual decrease in MBNL1 levels results both in the expansion of the repertoire of splice defects and an increase in the severity of the splice alterations. …”

Comparison of Friction Parametrization from Dynamics and Material Properties for a Coarse-Grained Polymer Melt by Lilian C. Johnson (16716416)

“…In this work, we extend an approach to coarse-grained (CG) modeling for polymer melts in which the conservative potential is parametrized using the iterative Boltzmann inversion (IBI) method and the accelerated dynamics inherent to IBI are corrected using the dissipative Langevin thermostat with a single tunable friction parameter (<i>J. …”

Association of Baseline HbA1c With Cardiovascular and Renal Outcomes: Analyses From DECLARE-TIMI 58 by Avivit Cahn (10072991)

“…<b>Objective:</b> Current guidelines recommend prescribing SGLT-2 inhibitors to patients with type 2 diabetes and established or at high risk for atherosclerotic cardiovascular disease (ASCVD), irrespective of HbA1c levels. We studied the association of HbA1c with cardiovascular and renal outcomes and whether the benefit of dapagliflozin varies by baseline HbA1c. …”

CheW-only linkers. by Stephan Eismann (835052)

DataSheet_1_Lactobacillus (LA-1) and butyrate inhibit osteoarthritis by controlling autophagy and inflammatory cell death of chondrocytes.pdf by Keun-Hyung Cho (6067610)

“…In this study, we evaluated the mechanism by which live LA-1 ameliorated OA. …”

DataSheet_1_Lung microbiome alterations in patients with anti-Jo1 antisynthetase syndrome and interstitial lung disease.docx by Teresa Quintero-Puerta (17559708)

“…</p>Methods<p>We sequenced the 16S ribosomal RNA gene in the BALF of anti-Jo1-positive (JoP, n=6) and non-Jo1-positive (NJo, n=17) patients, and the differential cell count in BALF was evaluated. …”

Data_Sheet_1_ExoS/ChvI Two-Component Signal-Transduction System Activated in the Absence of Bacterial Phosphatidylcholine.PDF by Otto Geiger (2180836)

“…However, as ExoR levels are similar in wild type, PC-deficient mutant and suppressor mutants, we propose that lack of PC in the bacterial membrane provokes directly a conformational change of the ExoS sensor and thereby activation of the ExoS/ChvI two-component system.…”

The <i>Trypanosoma cruzi</i> Vitamin C Dependent Peroxidase Confers Protection against Oxidative Stress but Is Not a Determinant of Virulence by Martin C. Taylor (449215)

“…</p><p>Methodology/Principal Findings</p><p>To assess the importance of TcAPx in protecting <i>T</i>. <i>cruzi</i> from oxidative stress and to determine if it is essential for virulence, we generated null mutants by targeted gene disruption. …”

Cyrtarachne Spreading on Moths from The moth specialist spider <i>Cyrtarachne akirai</i> uses prey scales to increase adhesion by Candido Diaz (1477900)

“…Here, we compare the spreading and adhesion of <i>Cyrtarachne akirai</i> glue on intact mothwings, denuded cuticle and glass to the glue of a common orb-weaving spider, <i>Larinioides cornutus,</i> to understand how <i>C. akirai</i> glue overcomes dirty surfaces. …”

Image_1_Herpes Simplex Virus Type 1 Enhances Expression of the Synaptic Protein Arc for Its Own Benefit.TIF by Francisca Acuña-Hinrichsen (6181544)

“…Finally, we found that silencing Arc protein caused a decrease in HSV-1 proteins and viral progeny, suggesting that Arc is involved in the lifecycle of HSV-1. …”

Data_Sheet_1_The Relation Between Capillary Transit Times and Hemoglobin Saturation Heterogeneity. Part 1: Theoretical Models.PDF by Adrien Lücker (5144969)

A structural variant in the 5’-flanking region of the <i>TWIST2</i> gene affects melanocyte development in belted cattle by Nivedita Awasthi Mishra (4179457)

“…We hypothesized that the CNV causes aberrant expression of <i>TWIST2</i> during neural crest development, which might negatively affect melanoblasts. …”

Image_1_Herpes Simplex Virus Type 1 Enhances Expression of the Synaptic Protein Arc for Its Own Benefit.TIF by Francisca Acuña-Hinrichsen (6181544)

“…Finally, we found that silencing Arc protein caused a decrease in HSV-1 proteins and viral progeny, suggesting that Arc is involved in the lifecycle of HSV-1. …”

Recognition of <i>F. novicida</i> strains by lysophagosomes and lysosomes in HeLa–FcγRII cells. by Dhandy Koesoemo Wardhana (21956781)

Recognition of <i>F. novicida</i> strains by the mitochondria and Golgi complex in THP-1 cells. by Dhandy Koesoemo Wardhana (21956781)

Image_5_Proteasome-Mediated Regulation of Cdhr1a by Siah1 Modulates Photoreceptor Development and Survival in Zebrafish.TIF by Warlen Pereira Piedade (9671738)

“…We confirmed that Siah1 targets Cdhr1a for proteasomal degradation by co-transfection and co-immunoprecipitation in cell culture. …”

Image_6_Proteasome-Mediated Regulation of Cdhr1a by Siah1 Modulates Photoreceptor Development and Survival in Zebrafish.TIF by Warlen Pereira Piedade (9671738)

“…We confirmed that Siah1 targets Cdhr1a for proteasomal degradation by co-transfection and co-immunoprecipitation in cell culture. …”

Image_2_Proteasome-Mediated Regulation of Cdhr1a by Siah1 Modulates Photoreceptor Development and Survival in Zebrafish.TIF by Warlen Pereira Piedade (9671738)

“…We confirmed that Siah1 targets Cdhr1a for proteasomal degradation by co-transfection and co-immunoprecipitation in cell culture. …”

Image_4_Proteasome-Mediated Regulation of Cdhr1a by Siah1 Modulates Photoreceptor Development and Survival in Zebrafish.TIF by Warlen Pereira Piedade (9671738)

“…We confirmed that Siah1 targets Cdhr1a for proteasomal degradation by co-transfection and co-immunoprecipitation in cell culture. …”

Baloxavir treatment of ferrets infected with influenza A(H1N1)pdm09 virus reduces onward transmission by Leo Yi Yang Lee (8713917)

“…We established a subcutaneous baloxavir administration method in ferrets which achieved similar pharmacokinetics to the approved human oral dose. …”