Search alternatives:
we decrease » _ decrease (Expand Search), teer decrease (Expand Search), use decreased (Expand Search)
nn decrease » _ decrease (Expand Search), gy decreased (Expand Search), b1 decreased (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
i we » i e (Expand Search), i de (Expand Search), i ae (Expand Search)
we decrease » _ decrease (Expand Search), teer decrease (Expand Search), use decreased (Expand Search)
nn decrease » _ decrease (Expand Search), gy decreased (Expand Search), b1 decreased (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
i we » i e (Expand Search), i de (Expand Search), i ae (Expand Search)
-
19861
Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for <i>In Vivo</i> Mouse Studies
Published 2024“…We discovered two new GPR88 agonists: One that reduced morphine-induced locomotor activity in a murine proof-of-concept study, and the atropoisomeric BI-9508, which is a brain penetrant and has improved pharmacokinetic properties and dosing that recommend it for future <i>in vivo</i> studies in rodents. …”
-
19862
Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for <i>In Vivo</i> Mouse Studies
Published 2024“…We discovered two new GPR88 agonists: One that reduced morphine-induced locomotor activity in a murine proof-of-concept study, and the atropoisomeric BI-9508, which is a brain penetrant and has improved pharmacokinetic properties and dosing that recommend it for future <i>in vivo</i> studies in rodents. …”
-
19863
Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for <i>In Vivo</i> Mouse Studies
Published 2024“…We discovered two new GPR88 agonists: One that reduced morphine-induced locomotor activity in a murine proof-of-concept study, and the atropoisomeric BI-9508, which is a brain penetrant and has improved pharmacokinetic properties and dosing that recommend it for future <i>in vivo</i> studies in rodents. …”
-
19864
Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for <i>In Vivo</i> Mouse Studies
Published 2024“…We discovered two new GPR88 agonists: One that reduced morphine-induced locomotor activity in a murine proof-of-concept study, and the atropoisomeric BI-9508, which is a brain penetrant and has improved pharmacokinetic properties and dosing that recommend it for future <i>in vivo</i> studies in rodents. …”
-
19865
Discovery of BI-9508, a Brain-Penetrant GPR88-Receptor-Agonist Tool Compound for <i>In Vivo</i> Mouse Studies
Published 2024“…We discovered two new GPR88 agonists: One that reduced morphine-induced locomotor activity in a murine proof-of-concept study, and the atropoisomeric BI-9508, which is a brain penetrant and has improved pharmacokinetic properties and dosing that recommend it for future <i>in vivo</i> studies in rodents. …”
-
19866
Geometrical Constraints Greatly Hinder Formin mDia1 Activity
Published 2019“…Combining microfluidics and micropatterning, we reconstituted in vitro mDia1 formin-elongated filament bundles induced by fascin, with different geometrical constraints on the formins, and measured the impact of these constraints on formin elongation rate and processivity. …”
-
19867
Geometrical Constraints Greatly Hinder Formin mDia1 Activity
Published 2019“…Combining microfluidics and micropatterning, we reconstituted in vitro mDia1 formin-elongated filament bundles induced by fascin, with different geometrical constraints on the formins, and measured the impact of these constraints on formin elongation rate and processivity. …”
-
19868
Geometrical Constraints Greatly Hinder Formin mDia1 Activity
Published 2019“…Combining microfluidics and micropatterning, we reconstituted in vitro mDia1 formin-elongated filament bundles induced by fascin, with different geometrical constraints on the formins, and measured the impact of these constraints on formin elongation rate and processivity. …”
-
19869
Geometrical Constraints Greatly Hinder Formin mDia1 Activity
Published 2019“…Combining microfluidics and micropatterning, we reconstituted in vitro mDia1 formin-elongated filament bundles induced by fascin, with different geometrical constraints on the formins, and measured the impact of these constraints on formin elongation rate and processivity. …”
-
19870
Regulatory Protein OmpR Influences the Serum Resistance of <i>Yersinia enterocolitica</i> O:9 by Modifying the Structure of the Outer Membrane
Published 2013“…We propose that OmpR might alter the susceptibility of <i>Y. enterocolitica</i> O:9 to complement-mediated killing through remodeling of the outer membrane.…”
-
19871
Integrating Paleodistribution Models and Phylogeography in the Grass-Cutting Ant <i>Acromyrmex striatus</i> (Hymenoptera: Formicidae) in Southern Lowlands of South America
Published 2016“…From the partial sequences of the mitochondrial gene cytochrome oxidase I of 128 <i>A</i>. <i>striatus</i> workers from 38 locations we estimated genetic diversity and inferred historical demography, divergence time, and population structure. …”
-
19872
Supplementary Table 3 from <i>Pendraig milnerae</i>, a new small-sized coelophysoid theropod from the Late Triassic of Wales
Published 2021“…We describe a new small-bodied coelophysoid theropod dinosaur, <i>Pendraig milnerae</i> gen. et sp. nov, from the Late Triassic fissure fill deposits of Pant-y-ffynnon in southern Wales. …”
-
19873
DataSheet1_Evaluation of the efficacy of mitochondrial fission inhibitor (Mdivi-1) using non-alcoholic steatohepatitis (NASH) liver organoids.docx
Published 2023“…Treatment of NLO with a DPR1 inhibitor, Mdivi-1 resulted in the improvement of morphology and the decreased expression of fibrosis-related markers, Col1a1 and Acta2. …”
-
19874
DNMT1-mediated demethylation of lncRNA MEG3 promoter suppressed breast cancer progression by repressing Notch1 signaling pathway
Published 2022“…In addition, we found that MEG3 expression was negatively correlated with DNMT1. …”
-
19875
Presentation1_Physical inactivity induces insulin resistance in plantaris muscle through protein tyrosine phosphatase 1B activation in mice.PPTX
Published 2023“…Insulin-stimulated phosphorylation levels of insulin receptor (IR), IR substrate-1, and Akt were reduced in parallel with the decrease in insulin sensitivity. …”
-
19876
The Receptor CMRF35-Like Molecule-1 (CLM-1) Enhances the Production of LPS-Induced Pro-Inflammatory Mediators during Microglial Activation
Published 2015“…The TLR4 agonist lipopolysaccharide (LPS) and the TLR3 agonist polyinosinic–polycytidylic acid (Poly I:C) induce an increase in microglial CLM-1 mRNA levels <i>in vitro</i>, whereas the TLR2/6 heterodimer agonist peptidoglycan (PGN) produces a marked decrease. …”
-
19877
Table1_Physical inactivity induces insulin resistance in plantaris muscle through protein tyrosine phosphatase 1B activation in mice.DOCX
Published 2023“…Insulin-stimulated phosphorylation levels of insulin receptor (IR), IR substrate-1, and Akt were reduced in parallel with the decrease in insulin sensitivity. …”
-
19878
DataSheet1_Myristate induces mitochondrial fragmentation and cardiomyocyte hypertrophy through mitochondrial E3 ubiquitin ligase MUL1.docx
Published 2023“…In this context, myristate increased MUL1 levels and induced mitochondrial fragmentation, associated with the decrease of the mitochondrial fusion protein MFN2, and with the increase of the mitochondrial fission protein DRP1, two targets of MUL1. …”
-
19879
Table_1_Transcriptomic, Biochemical, and Morphological Study Reveals the Mechanism of Inhibition of Pseudopestalotiopsis camelliae-sinensis by Phenazine-1-Carboxylic Acid.XLSX
Published 2021“…<p>Gray blight disease is one of the most destructive diseases of tea plants and occurs widely in the tea-growing areas of the world. …”
-
19880