Schematic representation of the experimental design. by Su-Juan Duan (14209983)

Effects of changing birth/death/transition rates on cell population dynamics. by Anshul Saini (11320669)

Both domains of obscurin Ig58/Ig59 are involved in binding titin ZIg9/ZIg10. by Daniela Rossi (1716643)

B lymphocytes in splenic germinal centers significantly depleted in BLyS^-/-. by Natalie M. Bath (6316517)

Palladium-Catalyzed Asymmetric Intramolecular Dearomative Heck Annulation of Aryl Halides to Furnish Indolines by Yuanfeng Li (217864)

“…An unprecedented Pd-catalyzed asymmetric intramolecular cascade cyclization of aryl halides with readily available arylboronic acids proceeds through a Heck-type dearomative cyclization terminated with arylation in the presence of Pd₂(dba)₃ (10 mol %), Cu₂O (5 mol %), and Cs₂CO₃ (2.0 equiv) in 1,2-dichloroethane (1.0 mL) at 100 °C for 15 h in air using BINOL-based phosphoramidite as the chiral ligand. …”

[¹¹C]CHIBA-1001 as a Novel PET Ligand for α7 Nicotinic Receptors in the Brain: A PET Study in Conscious Monkeys by Kenji Hashimoto (36400)

“…Interestingly, the binding of [¹¹C]CHIBA-1001 in the frontal cortex of the monkey brain was significantly decreased by subchronic administration of the N-methyl-D-aspartate (NMDA) receptor antagonist phencyclidine (0.3 mg/kg, twice a day for 13 days); which is a non-human primate model of schizophrenia.…”

Supplementary file 1_Phase angle as a predictor of prolonged length of hospital stay and adverse outcomes in elderly medical inpatients: a retrospective cohort study.docx by Jia Liu (41593)

“…Adverse event rates across the PhA tertiles (T1–T3) were 32.9%, 18.6%, and 5.6%, respectively, indicating a significant decrease in event incidence as PhA values increased. …”

Surface GPI-anchored proteins lose their membrane association in second cycle partially rescued delayed death (PRDD) <i>P</i>. <i>falciparum</i>. by Michaela S. Bulloch (19557058)

Sphingosine Kinase 1 Deficiency Exacerbates LPS-Induced Neuroinflammation by Natalia M. Grin’kina (164747)

“…A comparison of established neuroinflammatory parameters such as white matter rarefactions, development of cytotoxic edema, astrogliosis, loss of oligodendrocytes, and major cytokines levels in wild type and knockout mice suggested that the neuroinflammatory response in SphK1−/− mice was significantly upregulated. At 6 hours after intracerebroventricular injection of LPS in SphK1−/− mice, the immunoreactivity of the microglia markers and astrocyte marker glial fibrillary acidic protein (GFAP) were significantly increased, while the oligodendrocyte marker O4 was decreased compared to WT mice. …”

DPP6 regulates a channel with properties similar to TASK-3. by Brian M. Nadin (401054)

“…As expected expression of high levels of TASK-3 dramatically increases membrane resting conductance, much of which is sensitive to block by external pH 6.0. Scale bar: 20 mV, 50 ms. <b>C)</b> Summary results testing sensitivity of the resting conductance to external pH 6.0 (WT (n = 11), mDPP6 RNAi (n = 5), rDPP6 Rescue (n = 8), TASK-3 (n = 6)), 500 µM external Zn²⁺ (WT (n = 6), mDPP6 RNAi (n = 5), rDPP6 Rescue (n = 6), TASK-3 (n = 6)) and suppression by 10 µM muscarine (WT (n = 8), mDPP6 RNAi (n = 5), rDPP6 Rescue (n = 4), TASK-3 (n = 6)). …”

LPLUNC1 inhibited the expression of important molecules in the cell cycle pathway. by Yixin Yang (409184)

“…The relative expression levels of cyclin D1 and cyclin E1 were decreased in 5-8F/LPLUNC1 cells compared with the control; p<0.01 and p<0.05, respectively. …”

The impact of a breast cancer diagnosis on health-related quality of life. A prospective comparison among middle-aged to elderly women with and without breast cancer by Randi V. Karlsen (2545756)

“…</p> <p><b>Results</b> Women with breast cancer reported significantly larger decreases in HQoL from before to after diagnosis than those who remained breast cancer-free (physical component summary, −2.0; 95% CI −2.8; −1.2, mental component summary, −1.5, 95% CI −2.3; −0.6). …”

Data_Sheet_1_Case Report: Training Monitoring and Performance Development of a Triathlete With Spinal Cord Injury and Chronic Myeloid Leukemia During a Paralympic Cycle.zip by Oliver J. Quittmann (12653079)

“…Increased volumes at low intensity are assumed to increase P_OBLA and decrease V˙Lamax over time. CML treatment and side effects drastically decreased TL, intensity, and performance, which ultimately hindered a qualification for Tokyo 2020/21. …”

Data_Sheet_1_Case Report: Training Monitoring and Performance Development of a Triathlete With Spinal Cord Injury and Chronic Myeloid Leukemia During a Paralympic Cycle.zip by Oliver J. Quittmann (12653079)

“…Increased volumes at low intensity are assumed to increase P_OBLA and decrease V˙Lamax over time. CML treatment and side effects drastically decreased TL, intensity, and performance, which ultimately hindered a qualification for Tokyo 2020/21. …”

<i>Sox2</i> stimulates degradation of Atoh1 through ubiquitin E3 ligase, <i>Huwe1</i>, and knockout of <i>Sox2</i> or <i>Huwe1</i> results in supporting cell division. by Yen-Fu Cheng (5819855)

Sediment biomarkers elucidate the Holocene ontogeny of a shallow lake by T. E. Arnold (4760403)

“…Hydroclimate shifts in Florida were related to: 1) a steady rise in relative sea level and the fresh water table that began in the early Holocene, 2) wetland formation and expansion ca. 5,000 cal yrs BP, and 3) the onset of the modern El Niño (ENSO) cycle ~3,000 cal yrs BP. …”

Presentation1_Fat-1 Transgenic Mice With Augmented n3-Polyunsaturated Fatty Acids Are Protected From Liver Injury Caused by Acute-On-Chronic Ethanol Administration.PPTX by Jeffrey Warner (192528)

“…Male wild type (WT) and fat-1 littermates were provided an ethanol (EtOH, 5% v/v)-containing liquid diet for 10 days, then administered a binge of EtOH (5 g/kg) by oral gavage on the 11^th day, 9 h prior to sacrifice. …”

WTA stimulates in vitro T-cell activation by a MHC-II dependent mechanism. by Christopher Weidenmaier (240364)

“…The inhibitors bafilomycin A (BafA), brefeldin A (BrefA), colchicine, and cytochalasin D (CytoCalD) decreased T-cell proliferation induced by wt WTA (wt WTA with BafA: <i>p</i> = 0.0399; wt WTA with BrefA: <i>p</i> = 0.0230; wt WTA with Colchicine: <i>p</i> = 0.0042; wt WTA with CytoCalD; <i>p</i> = 0.0036) and <i>dltA</i> WTA (<i>dlt</i> WTA with BafA: <i>p</i> = 0.0220; <i>dlt</i> WTA with BrefA: <i>p</i> = 0.0026; <i>dlt</i> WTA with Colchicine: <i>p</i> = 0.0032; <i>dlt</i> WTA with CytoCalD: <i>p</i> = 0.0527). …”

DataSheet_1_Ocean acidification and ammonium enrichment interact to stimulate a short-term spike in growth rate of a bloom forming macroalga.pdf by Leah B. Reidenbach (4620856)

“…</p>Results<p>During the first five days of growth, there was a positive synergy between pCO₂ and NH₄⁺ enrichment, which could accelerate initiation of an Ulva bloom. …”

Feasibility and clinical impact of routine molecular testing of gastrointestinal cancers at a tertiary centre with a multi-gene, tumor-agnostic, next generation sequencing panel by Giacomo Bregni (9281195)

“…Success rate and median turnaround time were 91.4% and 12.5 days, respectively, both significantly decreasing over time (<i>p</i> ≤ .0002). …”