Lifelong Reduction of LDL-Cholesterol Related to a Common Variant in the LDL-Receptor Gene Decreases the Risk of Coronary Artery Disease—A Mendelian Randomisation Study by Patrick Linsel-Nitschke (87537)

“…</p><h3>Findings</h3><p>Each copy of the minor T allele of SNP rs2228671 within <em>LDLR</em> (frequency 11%) was related to a decrease of LDL-C levels by 0.19 mmol/L (95% confidence interval (CI) [0.13–0.24] mmol/L, p = 1.5×10⁻¹⁰). …”

Reduction of HIF-1α signaling enhances the endurance exercise capacity by increasing oxidation. by Jong-Seol Kang (14925926)

Lysine Mutation of the Claw-Arm-Like Loop Accelerates Catalysis by Cellobiohydrolases by Zhiyou Zong (7336904)

“…Experimental validation was performed using the full-length wild-type (WT) of <i>Te</i>Cel7A and its mutants, recombinantly expressed in <i>Pichia pastoris</i>, to degrade the substrates. …”

Data Sheet 1_Regulation of SLC7A11 by LncRNA GPRC5D-AS1 mediates ferroptosis in skeletal muscle: Mechanistic exploration of sarcopenia.pdf by Wei Gong (112494)

“…In the sarcopenia group, both GPRC5D-AS1 and SLC7A11 expression levels decreased significantly, along with SLC7A11 protein translation. …”

Supplementary file 1_Regulation of SLC7A11 by LncRNA GPRC5D-AS1 mediates ferroptosis in skeletal muscle: Mechanistic exploration of sarcopenia.pdf by Wei Gong (112494)

“…In the sarcopenia group, both GPRC5D-AS1 and SLC7A11 expression levels decreased significantly, along with SLC7A11 protein translation. …”

Hepatitis C Virus (HCV) Evades NKG2D-Dependent NK Cell Responses through NS5A-Mediated Imbalance of Inflammatory Cytokines by Damien Sène (237641)

“…Using an endotoxin-free recombinant NS5A protein, we show that NS5A stimulation of monocytes through Toll-like Receptor 4 (TLR4) promotes p38- and PI3 kinase-dependent IL-10 production, while inhibiting IL-12 production. …”

BA attenuated the decrease in the integrity and increase in the permeability of the epithelial barrier injury induced by LPS in Caco2 cell monolayers. by Luqiong Liu (11537092)

Target specificity, <i>in vivo</i> pharmacokinetics, and efficacy of the putative STAT3 inhibitor LY5 in osteosarcoma, Ewing's sarcoma, and rhabdomyosarcoma by Peter Y. Yu (4281448)

“…The purpose of this work was to develop and test a novel putative STAT3 inhibitor, LY5.</p><p>Methods and findings</p><p>An <i>in silico</i> fragment-based drug design strategy was used to create LY5, a small molecule inhibitor that blocks the STAT3 SH2 domain phosphotyrosine binding site, inhibiting homodimerization. …”

LY5 inhibits STAT3 phosphorylation in lung metastases but does not inhibit lung metastasis formation. by Peter Y. Yu (4281448)

LY5 does not inhibit growth of <i>ex vivo</i> pulmonary metastasis. by Peter Y. Yu (4281448)

p12 carries a signal peptide that is cleaved via the signal peptidase complex (SPC). by Florian Simon (5387228)

Endogenous IRE1 protein can localize to the nuclear envelope. by Iratxe Zuazo-Gaztelu (21071939)

Decreased number of myofibroblasts on stiff-to-soft gels was not due to apoptosis. by Huan Wang (109286)

Acute JMV2959 treatment decreases alcohol intake in rats. by Petra Suchankova (400313)

“…<p>(A) The acute effects of the GHS-R1A antagonist JMV2959 (1 or 3 mg/kg) administration on alcohol intake was evaluated at 1 hour time interval after both two and five months of voluntary alcohol consumption. …”

Table_1_Tipping point of plant functional traits of Leymus chinensis to nitrogen addition in a temperate grassland.DOCX by Guojiao Yang (12158151)

“…We chose the native, perennial clonal grass, Leymus chinensis in Inner Mongolia steppe, and conducted a field experiment, in which six N addition rates (0, 2, 5, 10, 20, and 50 g N m^–2 year^–1) and five N compound types [NH₄NO₃, (NH₄)₂SO₄, NH₄HCO₃, CO(NH₂)₂, slow-release CO(NH₂)₂] are considered. …”

Acute JMV2959 treatment decreases alcohol preference in rats. by Petra Suchankova (400313)

“…<p>(A) Acute administration of the GHS-R1A antagonist JMV2959 (1 or 3 mg/kg) decreases the alcohol preference compared to vehicle at 1 hour time interval in rats voluntarily consuming alcohol for two and five months before the treatment. …”

Inhibition of the lysosomal protease decreased the apoptosis induced by EV71. by Xueyan Xi (5654083)

Cellular viability decreases in breast cancer cells treated with clotrimazole. by Cristiane M. Furtado (333360)

Procedure for decreasing the required time for fire resistance of the multistory buildings by V. P. SILVA (4642840)

Rat tickling: A systematic review of applications, outcomes, and moderators by Megan R. LaFollette (3911140)

“…The most common method used for tickling was cycling through 15 seconds of tickling and 15 seconds of rest for 2 minutes for 3 to 5 days. Experiments with a control for tickling (N = 22) showed that tickling increases positive vocalization, approach behavior, decreases anxiety measures, improves handling, and in some cases decreases stress hormones. …”